ABSTRACT
Objective To analyze the epidemiological characteristics of measles cases with immunization history of measles-containing vaccine (MCV), and to provide a basis for improving measles prevention and control measures. Methods Data were collected through the measles surveillance system and the immunization program information management system. Data were analyzed by descriptive epidemiological methods. Results A total of 9 164 cases of measles were reported in Liaoning Province during 2014-2021, of which the cases of measles with immunization history of 1 dose MCV accounted for 5.64%, and ≥ 2 doses accounted for 3.60%. There was a statistically significant difference in the immunization proportion among different years (χ2=184.534, P2=109.448, P2=4.147, P<0.05). The onset time of most cases was over 2 weeks after the last dose of MCV vaccination, accounting for 82.06%. The incidence rates of fever, cough, catarrh symptoms, conjunctivitis, lymph node enlargement and articular pain were all significantly lower in the cases with immunization history than those in the patients without a history of MCV immunization (P<0.05). Conclusion The cases with immunization history account for a certain proportion in measles cases, mainly secondary vaccination failure. The incidence rate of fever, cough, catarrhal symptoms, conjunctivitis, Koch's patches, lymphadenopathy, joint pain, and other clinical symptoms in measles patients with a history of MCV immunization is lower than that in patients without immunization history. Inoculation of MCV is of great significance in relieving clinical symptoms. It is necessary to inoculate two doses of MCV in time for measles prevention and control.
ABSTRACT
[Objective]To analyze the IgM antibody detection results for suspected cases of measles from2013 to 2016 in Changshu City, in order to provide basis for formulation of strategies of prevention and control of measles. [Methods] The serum samples of 367 suspected measles cases were detected for measles IgM by enzyme linked immunosorbent (ELISA) methods. [Results] The serum samples of 246 suspected measles cases were measles IgM positive, the positive rate being 67.03％. The number of cases of measles obviously increased in 2015 and 2016, and the paroxysm of measles tended to occur in the population of low and older ages, showing dipolar pattern. The differences of IgM antibody between different age groups had statistical significance (χ2= 27.03, P < 0.01). Measles broke out mainly from March to August, when there were obvious differences on the positivity of IgM antibody detected at different times after rash occurrence (χ2= 13.62, P < 0.01). [Conclusion] Measles immunization should be enhanced and measles vaccination replenished properly. It is also necessary to raise the rate of measles vaccination among children of suitable age within the jurisdiction. Strengthen monitoring on measles in floating population, enhance vaccine replanting and revaccination of measles in floating population, adult and fertile women and enhance immune level in high incidence population.