A Case of Erosive Pustular Dermatosis of the Scalp / 대한피부과학회지

Erosive pustular dermatosis of the scalp is a rare disorder of the elderly and it is characterized by pustular, erosive and crusted lesions of the scalp with progressive scarring alopecia. The predisposing factors have been reported to be trauma, including mechanical trauma, skin grafting, surgery and prolonged exposure of a bald scalp to UV light. Yet the laboratory data, the bacteriological and mycological investigations and the histopathologic findings of the previously reported cases were generally negative and not diagnostic. We herein present a case of erosive pustular dermatosis of the scalp that occurred after mechanical trauma on the previous skin graft site. This type of case has not been previously reported in the Korean dermatologic literature.

Experimentally Induced Polyps in the Rabbit Maxillary Sinuses: Effects of Different Bacterial Infections with or without Mechanical Trauma on Polyp Formation / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Many studies have been made on sinonasal polyps to elucidate their pathogenesis, definition and treatment. However, recently reported animal polyp studies provided only a few comparative results of polyp formation under various conditions. The aim of this study is to develop an animal model of polyps that is more suitable for further polyp studies by semi-quantitatively analyzing the effects of different bacterial infections with or without mechanical trauma to the rabbit maxillary sinus (MS) mucosa on polyp formation. MATERIALS AND METHODS: The natural ostia of the right MSs were occluded in 40 Pasteurella-free New Zealand white rabbits. The left MSs were used as control. All rabbits were divided into four groups according to different manipulations on the right MSs; Streptococcus pneumoniae was inoculated without brushing the mucosa (group A) and with brushing (group B), Pseudomonas aeruginosa was inoculated without brushing (group C) and with brushing (group D). After four weeks, macroscopic polyps and light microscopic polyps and/or polypoid mucosa were semi-quantitatively analyzed. RESULTS: The number of macroscopic polyps per sinus of group A was significantly smaller than those of groups B, C and D. Microscopic examination revealed significantly higher levels of polyps and/or polypoid mucosa in group B than in group A, but significantly lower levels in group B than in groups C and D. CONCLUSION: P. aeruginosa infection of the rabbit MS proved more beneficial to polyp formation than S. pneumoniae infection, regardless of mechanical trauma to the sinus mucosa. However, for the inoculation of MS with S. pneumoniae, it was more beneficial to poly induction if the mucosa was mechanically traumatized.

Effects of Mechanical Trauma to the Sinus Mucosa on Polyp Formation in Induction of Maxillary Sinusitis in Rabbits by Streptococcus Pneumoniae / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Pathogenesis, definition, and treatment of sinonasal polyps remain uncertain. To elucidate them, many studies on polyps have been made. However, recently reported studies on polyps using animal models seldom provided comparative data on polyp formation in various conditions. The aim of this study is to develop an animal model of polyps which is more suitable for further polyp studies. We attempted a semiquantitative analysis on the effects of mechnical trauma to the sinus mucosa on formation of polyps and polypoid mucosa in duction of rabbit maxillary sinusitis by Streptococcus pneumoniae and compared the prevalences of polyps under the different conditions. MATERIALS AND METHODS: The natural ostia of both sinuses were occluded in 10 Pasturella-free New Zealand white rabbits. Both sinuses were inoculated with S. pneumoniae, without brushing the mucosa in the left maxillary sinuses (control group) and with brushing in the right sinuses (experimental group). After four weeks, all sinuses were re-opened. Macroscopic polyp and light microscopic polyps and/or polypoid mucosa were semiquantitatively analyzed and each prevalence was compared between the two groups. RESULTS: The number of macroscopic polyps per sinus was significantly larger in the experimental group (1.1 polyps) than that in the control group (0.1 polyps). Microscopic examination revealed significantly more polyps and/or polypoid mucosa in the experimental group than in the control group. CONCLUSIONS: Our results suggest that mechanically traumatizing the sinus mucosa, such as brushing, is more helpful to polyp formation when a rabbit model of polyps is to be induced by S. pneumoniae.

Effects of Pseudomonas Aeruginosa Infection and Mechanical Trauma to the Sinus Mucosa on Polyp Formation in the Rabbit Maxillary Sinuses

The aim of this study is to develop an animal model of polyps that is more suitable for further polyp studies by semiquantitatively analyzing the effects of Pseudomonas aeruginosa infection and/or mechanical trauma to the sinus mucosa, based on the epithelial rupture theory, on polyp formation in the rabbit maxillary sinuses. The natural ostia were occluded in 30 Pasturellafree New Zealand white rabbits. All rabbits were divided into three groups according to the following modes of manipulation on the right maxillary sinus: inoculation with P. aeruginosa (group A), brushing of the sinus mucosa (group B), and inoculation with P. aeruginosa accompanied by brushing of the mucosa (group C). The left maxillary sinuses were used as the control. After four weeks, macroscopic polyps and light microscopic polyps and/or polypoid mucosa were semiquantitatively analyzed. The number of macroscopic polyps per sinus was significantly larger in groups A (1.0 polyps) and C (1.3 polyps) than in group B (0.0 polyps). Microscopic examination revealed significantly higher levels of polyps and/or polypoid mucosa in groups A and C than in group B. The results of this study suggest that a rabbit model of polyps using P. aeruginosa is suitable for further polyp studies and that induction of this type of model needs no mechanical trauma to the sinus mucosa.