ABSTRACT
Objective To observe the curative effects of Mailuoning oral liquid combined with Mecobalamin tablets in treating aged diabetic peripheral neuropathy (DPN).Methods Forty-nine patients with DPN were randomly divided into treatment group (n=25) and control group (n=24).The patients in two groups were given Mecobalamin tablets,and the treatment group was added treated with Mailuoning oral liquid.The period of treatment was 3 months.Scores of Toronto clinical scoring system (TCSS) and traditional Chinese medicine (TCM) symptoms quantitative scale were compared between the two groups.The curative effects of all the patients were judged by the TCM symptoms quantitative scores.Results The TCSS levels in two groups after treatment were both significantly lower than those before treatment (all P<0.05).The TCSS level after treatment in treatment group was significantly lower than that in control group (P<0.05).The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that before treatment (P<0.05).The TCM symptoms quantitative score after treatment in treatment group was significantly lower than that in control group (P<0.05).The total effective rate in treatment group (88%) was significantly higher than that in control group (50%) (χ2=6.631,P=0.01).Conclusion Mailuoning oral liquid combined with Mecobalamin tablets is safe and effective for treating DPN.
ABSTRACT
Objective To observe the clinical efficacy in treatment on diabetic peripheral neuropathy (DPN) by Chinese medicine lavipeditum of blood-activating and Qufengchushi with mecobalamin tablets. Methods 65 diabetic patients were randomly divided into 2 groups. The two groups were both undertaking the diabetes diet control, exercise, diabetes education and maintaining previous hypoglycemic program. The patients with hypertension could take nifedipine GITS. Patients in control group only received mecobalamin tablet. Patients in treatment group received the same medication and also lavipeditum with Blood-activating and Qufengchushi traditional Chinese medicine for 12 weeks. Clinical symptom score, Toronto clinical score, motor nerve conduction velocity (MNCV) and sensory conduction velocity (SNCV) of median nerve and peroneal nerve were performed before and after the study. Results After treatment, the mean values for clinical symptom score, Toronto clinical score, MNCV and SNCV of median nerve and peroneal nerve of the tweo groups were all significantly decreased (P<0.05, P<0.01). The values for TCM clinical syndromes in treatment group was 81.81% (27/33), and that in the control group was 65.62% (21/32), with significant difference (P<0.05). The values for western medcine clinical syndromes in treatment group was 84.84% (28/33), and that in the control group was 62.50%(20/32), with significant difference (P <0.05). Conclusion Chinese medicine lavipeditum of Blood-activating and Qufengchushi with mecobalamin tablets is safet and effective in treating DPN.