ABSTRACT
The median palatine cyst is a rare fissural cyst of nonodontogenic origin located in the midline of the hard palate, posterior to the palatine papilla. Its etiology is generally attributed to the enclavement of remnants of epithelium surrounding the two lateral maxillary processes that fuse to form the hard palate. The median palatine cyst sometimes poses challenges in the diagnosis due to the diversity and complicated classifications of the cysts originating from the maxilla and palate. We present a case of large median palatine cyst of a 50-year-old man who had purulent rhinorrhea and foul odor for 1 year. An endonasal endoscopic marsupialization was performed and pus was drained from the cyst. There was no recurrence of symptoms and the ostium was well maintained at 4 months after the operation. We report this case with a brief literature review.