Desempenho no Teste Dicótico de Sentenças em Adultos com queixa comunicativa / Dichotic Sentences Test Performance of Adults with communication complaints

RESUMO Objetivo Analisar o desempenho de adultos normo-ouvintes com queixa comunicativa no Teste Dicótico de Sentenças. Método Selecionou-se em banco de dados, 15 participantes normo-ouvintes com resultados normais no Teste Dicótico de Dígitos, idades entre 19 a 44 anos, destros, que referiram queixa comunicativa. O Teste de Dicótico de Sentenças foi aplicado por meio de dois protocolos compostos por quatro diferentes combinações de listas denominados de sequências 1 e 2, de acordo com a seguinte ordem: treino, etapa de atenção dividida, etapas de atenção direcionada à direita e à esquerda. Resultados Na sequência de aplicação 1, a média de desempenho na etapa de atenção dividida foi 84,67% na orelha direita e 60,67% na esquerda, com diferença estatística entre orelhas, com assimetria entre orelhas variando de -50% a 60%. Na etapa de atenção direcionada, a média de desempenho foi 99,33% na orelha direita e 98% na esquerda, sem diferença estatística. Na sequência de aplicação 2, houve tendência de melhores resultados, mais acentuada na orelha esquerda, sem significância estatística, mantendo elevadas a variação de desempenho e a assimetria entre orelhas. Verificou-se na comparação entre as sequências, na etapa de atenção dividida, que na orelha direita 40% dos indivíduos não variaram, 33% pioraram, 26,7% melhoraram; na orelha esquerda, 6,6% não variaram, 20% pioraram e 73,33% melhoraram. Na etapa de atenção direcionada houve estabilidade nos resultados. Conclusão Os adultos normo-ouvintes, com queixas comunicativas, apresentaram um perfil heterogêneo, especialmente na etapa de atenção dividida, com acentuada diferença entre as orelhas e variabilidade de respostas.

ABSTRACT Purpose To analyze the performance of normal-hearing adults with communication complaints in the Dichotic Sentences Test. Methods We selected from the database 15 normal-hearing participants with normal results in the Digits Dichotic Test, aged between 19 and 44 years, right-handed, who reported communicative complaints. The Dichotic Sentences Test was applied using two protocols consisting of four different combinations of lists called sequences 1 and 2, in the following order: training, divided attention step, right and left directed attention steps. Results In the first application sequence, the average performance in the divided attention step was 84.7% for the right ear and 60.67% for the left, with statistical difference between ears. The asymmetry between ears varied from -50% to 60%. In the directed attention step, the average performance was 99.33% for the right ear and 98% for the left, with no statistical difference. In the second application sequence, there was a tendency for better results, more pronounced for the left ear, with no statistical significance, with the performance variation and asymmetry between ears remaining high. In the comparison between the sequences, in the divided attention step, it was found that, for the right ear, 40% of the individuals did not vary, 33% performed worse, and 26.7% performed better; for the left ear, 6.6% did not vary, 20% performed worse, and 73.33% performed better. There was result stability in the directed attention step. Conclusion The normal-hearing adults with communication complaints presented a heterogeneous profile, especially in the divided attention step, with a marked difference between ears and response variability.

Rehabilitación propioceptiva del síndrome de hombro doloroso / Proprioceptive rehabilitation of painful shoulder syndrome / Reabilitação proprioceptiva da síndrome do ombro doloroso

El hombro es una de las regiones anatómicas de mayor movilidad en la vida cotidiana, siendo una de las causas de consulta más frecuentes en el área de fisioterapia para su rehabilitación, pues la primera línea de acción es el tratamiento conservador del hombro; por ello, es de suma importancia conocer y evaluar el complejo articular del hombro, así como también de la región cervicotorácica, con los resultados de la valoración establecer una estrategia de tratamiento que pueden ir desde la terapia manual, el masaje terapéutico, cambios de temperatura hasta el empleo de otros agentes físicos. Paciente femenino de 42 años, con ocupación de asistente odontológica; no reporta discapacidad previa. Como antecedente médico se presenta accidente de tránsito en motocicleta sin producir fractura de hueso ni luxación, ocurrido ocho años antes de la consulta en fisiatría, la paciente tiene afectado el desarrollo de las actividades de la vida cotidiana. Recibió serie de tratamientos durante 10 sesiones, en las cuales se aplican agentes físicos, dado que anteriormente recibió tratamiento farmacológico sin resultados favorables. Se aplica protocolo de rehabilitación fundamentado en las técnicas de propiocepción y al finalizar la terapia la paciente reporta dolor leve, y mejora en la realización de actividades de la vida diaria.

The shoulder is one of the anatomical regions of greater mobility in daily life, being one of the most frequent causes of consultation in the area of physiotherapy for rehabilitation, since the first line of action is the conservative treatment of the shoulder; therefore, it is of utmost importance to know and evaluate the articular complex of the shoulder, as well as the cervicothoracic region, with the results of the assessment to establish a treatment strategy that can range from manual therapy, therapeutic massage, temperature changes to the use of other physical agents. Female patient, 42 years old, with occupation as a dental assistant; she reports no previous disability. As medical history, she had a traffic accident on a motorcycle without bone fracture or dislocation, which occurred eight years before the physiatry consultation, the patient has affected the development of activities of daily living. She received a series of treatments during 10 sessions, in which physical agents are applied, since she had previously received pharmacological treatment without favorable results. Rehabilitation protocol based on proprioception techniques is applied and at the end of therapy the patient reports mild pain and improvement in the performance of activities of daily living.

O ombro é uma das regiões anatômicas de maior mobilidade na vida diária, sendo uma das causas mais freqüentes de consulta na área de fisioterapia para reabilitação, pois a primeira linha de ação é o tratamento conservador do ombro; portanto, é extremamente importante conhecer e avaliar o complexo articular do ombro, bem como a região cervicotorácica, com os resultados da avaliação para estabelecer uma estratégia de tratamento que pode variar desde a terapia manual, massagem terapêutica, mudanças de temperatura até o uso de outros agentes físicos. Paciente do sexo feminino, 42 anos de idade, trabalhando como assistente odontológica; nenhuma deficiência anterior foi relatada. O histórico médico inclui um acidente de trânsito em uma motocicleta sem fratura ou deslocamento ósseo, que ocorreu oito anos antes da consulta ao fisiatra; as atividades de vida diária do paciente são afetadas. Ela recebeu uma série de tratamentos durante 10 sessões, nas quais foram aplicados agentes físicos, já que ela havia recebido anteriormente tratamento farmacológico sem resultados favoráveis. Um protocolo de reabilitação baseado em técnicas de propriocepção foi aplicado e ao final da terapia o paciente relatou dor leve e melhora no desempenho das atividades da vida diária.

Prevalence of hepatitis B & C infections in prospective blood donors deferred due to history of jaundice

Background & objectives: As per national guidelines, prospective blood donors with a history of jaundice of unknown cause are deferred permanently to prevent the transmission of hepatitis B and C. The validity of this guideline was tested by comparing prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice, with that of donors who were found fit. Methods: Blood samples of 212 consecutive donors (male, n=203) deferred due to a history of jaundice were studied for hepatitis B and C by rapid test kits as well as by chemiluminescence (n=115) or ELISA (n=97). Consecutive healthy donors (n=549; male, n=518) were also studied by ELISA (n=266) or chemiluminescence (n=283). Results: The cumulative prevalence detected by rapid test kit and ELISA/chemiluminescence tests of hepatitis B (n=10) and C (n=2) among donors deferred due to a history of jaundice (n=212) was 5.7 per cent [95% confidence interval (CI): 2.9, 9.9]. The prevalence of reactive results among healthy donors (n=549) by ELISA/chemiluminescence tests was 3.3 per cent (95% CI: 1.9, 5.2), which included hepatitis B (n=15) and hepatitis C (n=3) cases. Compared to healthy donors, the odds of seropositivity among jaundice-deferred donors was 1.7 (95% CI: 0.8, 3.6), P=0.15. For rapid test-negative deferred donors, the odds of seropositivity by ELISA/chemiluminescence declined to 0.4 (0.1, 1.5), P=0.19. Interpretation & conclusions: The prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice of unknown aetiology did not differ significantly from that in healthy donors. The current practice of permanently deferring such donors depletes valuable donor pool. A strategy of rejecting only those donors who are found reactive on pre-donation testing by rapid test needs further validation.

A liberdade de (se) narrar no ensino da semiologia médica / The freedom to (self) narrate in teaching medical semiology

Resumo: Introdução: Ao escrever sobre o ensino de semiologia, escrevo sobre histórias, imagens, signos e símbolos; sobre percepções, interpretações, encontros e desencontros. É a história do outro que se entrelaça com a minha, pois, ao ouvir, ver e examinar um paciente, vou além do que é aprendido nos livros de medicina. Neste artigo, falo de uma insurreição contra essa ditadura técnico-cognitiva no ensino da semiologia. Desenvolvimento: A anamnese médica é o relato da história do paciente, além de conter a descrição do exame físico realizado. Basicamente, é o resumo do encontro clínico, que vai guiar o caminho do médico na sua formulação diagnóstica e no planejamento dos cuidados necessários para cada paciente, e é ensinada de forma metódica e rígida, sem considerar a "história" da pessoa que conta, e sim a doença que ela tem. A abordagem deste trabalho é qualitativa, e adotou-se o método da cartografia, que se associa bem com a fenomenologia e permite acompanhar o meu percurso nesta narrativa. É o meu percurso como professora de semiologia médica que trago neste artigo, como material de estudo. Vou dividir essa trajetória da docência em três momentos ("O começo", "O 'divisor de águas'" e "Redescoberta"). Conclusão: A inserção das humanidades e das narrativas no curso de Medicina traz uma reflexão fundamental e necessária sobre o fazer médico e o próprio ensino na saúde. Usar o método da cartografia e as reflexões surgidas nesse caminhar pode contribuir para uma formação docente mais humanizada, com uma visão mais ampla da saúde e do ensino na saúde.

Abstract: Introduction: When writing about teaching semiology/clinical skills, I write about stories, images, signs and symbols; about perceptions, interpretations, encounters and mismatches. It is the other's story that intertwines with mine, because when listening, seeing, examining a patient, one goes beyond what is learned in medical books. In this paper, I talk about an insurrection against this technical cognitive dictatorship in the teaching of semiology. Development: Medical anamnesis is the reporting of the patient's history, in addition to the description of the physical examination performed. Basically, it is a summary of the clinical encounter, which will guide the doctor's path in his diagnostic formulation and planning of the necessary care for each patient. Moreover, it is taught in a methodical and rigid manner, without taking into account the "story" of those who tell it, but rather of the disease that the patient is carrying. This qualitative approach involved the method of cartography, which is tightly associated with phenomenology; it allows me to follow my path in this narrative. It is my journey, as a professor of clinical skills, that I bring here as study material. I divide this trajectory of teaching into three moments (the beginning, the watershed and rediscovery). Final considerations: The inclusion of humanities, narratives, in the medical course, brings a fundamental and necessary reflection on medical practice, and on health education itself. Using the cartography method and the reflections that emerged along this path can contribute to a more humanized teacher education, with a broader view of health, and of teaching in health.

Protocolos fonoaudiológicos de história clínica: revisão integrativa / Clinical history speech-language pathology protocols: integrative review

RESUMO Objetivo identificar, coletar e analisar, na literatura científica, evidências da existência de protocolos fonoaudiológicos de levantamento da história clínica, conforme classificação de risco, especialmente para distúrbios oromiofuncionais, em lactentes e pré-escolares. Estratégia de pesquisa foram selecionados estudos publicados, sem delimitação temporal, nas bases de dados eletrônicas LILACS, SciELO e PubMed e na literatura cinza (Google Acadêmico). Critérios de seleção estudos disponíveis na íntegra nas línguas portuguesa e inglesa, que identificassem protocolos fonoaudiológicos de história clínica aplicáveis a lactentes (6 a 23 meses de vida) e pré-escolares (24 a 71 meses de vida). Foram excluídas as revisões narrativas e de literatura (integrativa, sistêmica e escopo). Resultados foram encontradas 1371 publicações brasileiras no período de 1980 a 2022. Destas, foram identificadas apenas cinco que tratavam de protocolos fonoaudiológicos para levantamento de dados pregressos a partir da história clínica da faixa etária de 6 a 71 meses. Apenas um desses protocolos possuía classificação de risco para distúrbios fonoaudiológicos, distribuídos na área de linguagem e fluência. Os outros três eram da área de motricidade orofacial (MO) e não continham classificação de risco para distúrbio miofuncional orofacial. Conclusão existem poucos protocolos fonoaudiológicos para levantamento da história clínica de lactentes e pré-escolares que contenham, ou não, classificação de risco, publicados em revistas de acesso aberto e que passaram por processos completos de validação, sendo necessário ampliar estudos e publicações desses instrumentos, inclusive na área de MO.

ABSTRACT Purpose to identify, collect and analyze in the scientific literature evidence of the existence of speech therapy protocols for collecting clinical history, according to risk classification, especially for oromyofunctional disorders, in infants and preschoolers. Research Strategy We selected published studies, without temporal delimitation, in the electronic databases LILACS, SciELO and PUBMED; and in the gray literature (Google Academic). Selection criteria available in full in Portuguese and English, which identify speech-language pathology protocols of clinical history applicable to infants (6 to 23 months of age) and preschoolers (24 to 71 months of age). Narrative and literature reviews (integrative, systemic, and scope) were excluded. Results 1371 Brazilian publications were found in the period from 1980 to 2022. Of these, only five publications on speech therapy protocols were identified for collecting previous data from the clinical history of the age group between 6 and 71 months. Only two of these protocols have a risk classification for speech-language disorders, distributed in the areas of language and fluency. The other three are from the Orofacial Motricity (OM) area and do not carry a risk classification for orofacial myofunctional disorder. Conclusion There are few speech therapy protocols for surveying the clinical history of infants and preschoolers, whether or not they contain risk classification, published in open access journals that have a complete validation process.Therefore there is a need for more research and publication of these instruments, including in the area of OM.

Protocolo MMBRG - Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial / MMBGR Protocol - infants and preschoolers: Instructive and Orofacial Myofunctional Clinical History

RESUMO Objetivo Apresentar Instrutivo e Protocolo de História Clínica Miofuncional Orofacial pertencentes ao Protocolo MMBGR - Lactentes e Pré-escolares, incluindo adaptação e validação do conteúdo e aparência destes. Método Estudo tipo validação, descritivo e transversal. Adaptação a partir do Protocolo MBGR, fundamentada em estudos teóricos e experiência dos autores. Considerados lactentes entre 6 e 23 meses de vida e pré-escolares entre 24 e 71 meses. Obtido consentimento e consenso da versão adaptada pelos autores (originais e atuais). Analisados aparência e conteúdo do novo instrumento por 10 fonoaudiólogos especialistas em Motricidade Orofacial. Realizadas duas rodadas de análise: Primeira com formulário eletrônico contendo questões dicóticas (sim/não), com espaço para justificar as respostas negativas; calculado Índice de Validade de Conteúdo e Teste Binomial Exato; e Segunda com escala Likert 5 posições. Resultados Produzido instrutivo inédito e adaptado o Protocolo de História Clínica, com manutenção de 23 itens pertinentes à faixa etária em questão. Excluídas informações em 7 itens e acrescidas em 8 itens. Inicialmente obteve-se concordâncias de 70% do instrutivo, por pelo menos 70% dos especialistas; e 64% dos itens da História Clínica, por ao menos 90% dos especialistas. Obteve-se na segunda rodada 100% de respostas "Concordo totalmente" dos especialistas. Conclusão "Instrutivo" e "História Clínica Miofuncional Orofacial" tiveram validade de conteúdo e aparência concluída, e junto ao "Exame Clínico" integram o "Protocolo MMBGR - Lactentes e Pré-escolares", com potencial contribuição para atuação clínica e na pesquisa em Motricidade Orofacial na faixa etária de 6 meses a 5 anos e 11 meses de idade.

ABSTRACT Purpose To present Myofunctional Orofacial Clinical History Instructive and Protocol belonging to the MMBGR Protocol - Infants and Preschoolers, including the adaptation and validation of content and appearance. Methods Validation, descriptive and cross-sectional study. Adaptation based on the MBGR Protocol, based on theoretical studies and the authors' experience. Infants between 6 and 23 months of age and preschoolers between 24 and 71 months were considered. Consent and consensus of the version adapted by the authors (original and current) was obtained. The appearance and content of the new instrument were analyzed by 10 speech therapists specialized in Orofacial Motricity. We performed two analysis rounds. First: an electronic form containing dichotic questions (yes / no), with justification for negative answers; Content Validity Index and Exact Binomial Test; Second: 5 points-Likert scale. Results We produced an unprecedented instructional and adapted Clinical History protocol maintaining 23 age group related items. We excluded information from 7 items and included information in 8. Initially, we achieved agreement in 70% instructional specialist items by at least 70% of the specialists; and 64% of Clinical History items, by at least 90% of specialists. In the second round, there were 100% of "I totally agree" responses from the experts. Conclusion "Instructive" and "Myofunctional Clinical History, Orofacial" had validity of content and appearance concluded, and together with the "Clinical Examination" they integrate the "Protocol MMBGR - Infants and Preschoolers", being able to contribute to clinical practice and research in Motricity Orofacial area in the age group between 6 months and 5 years and 11 months of age.

Distribuição da semiologia do adulto nas escolas médicas do Brasil / Distribution of adult semiology in medical schools in Brazil

Resumo: Introdução: A semiologia é a base da prática clínica e seu ensino é essencial no curso de Medicina. Este estudo foi desenvolvido por haver uma lacuna no conhecimento sobre sua distribuição no Brasil. Objetivo: Este estudo teve como objetivo analisar a distribuição da semiologia do adulto nas escolas médicas brasileiras. Método: Trata-se de um estudo transversal descritivo realizado com 226 escolas médicas brasileiras que disponibilizavam a distribuição de semiologia na internet entre as 335 ativas, em dezembro de 2020 (67,5%). As variáveis estudadas foram região geográfica, administração, gratuidade e tempo de existência da escola, carga horária do curso, do internato e de semiologia, e ano(s) ou semestre(s) em que a semiologia era ofertada no currículo. A análise dos dados foi descritiva, e analisaram-se as associações com os testes: t de Student, análise de variância, qui-quadrado de Pearson, U de Mann-Whitney, Kruskal-Wallis e Wilcoxon. Admitiu-se um nível de significância de p < 0,05. Resultado: A semiologia foi mais frequentemente ofertada apenas no quarto semestre (n = 40), seguida por sua oferta em dois semestres: quarto e quinto e terceiro e quarto. Entre as 226 escolas, 142 integravam os conteúdos em módulos ou eixos (62,8%). Entre 117 escolas que forneciam a carga horária de semiologia, mediana foi de 240,0 horas (P25-75 = 165,4 - 338,2), sem diferença estatística por região geográfica, administração, gratuidade e tempo de existência da escola. A mediana da carga teórica de semiologia [77,5 horas (P25-75 = 51,7 - 123,5)] foi menor do que a carga prática [147,0 horas (P25-75 = 64,5 - 180,0)], Z = -3,99, p < 0,01. A mediana da porcentagem da carga horária de semiologia no curso foi de 2,9% (P25-75 = 2,0 - 4,0). Conclusão: A semiologia é mais frequentemente ofertada no quarto semestre, e sua carga horária não difere por características geográficas, de administração e tempo de existência das escolas estudadas.

Abstract: Introduction: Semiology is the basis of clinical practice and its teaching is essential in the medical course. This study was developed to fill a gap in the knowledge about its distribution in Brazil. Objective: To analyze the distribution of adult semiology in Brazilian medical schools. Method: Cross-sectional descriptive study with 226 Brazilian medical schools that provided the distribution of semiology on the Internet among the 335 active schools in December 2020 (67.5%) The variables studied were school geographic region, administration and free tuition, time of existence of the course, course load of the regular course, clerkship and semiology, and year(s) or semester(s) in which semiology was offered in the curriculum. Data analysis was descriptive and the associations were analyzed using: Student's t, Chi-square, Analysis of Variance, Mann-Whitney-U, Kruskal Wallis and Wilcoxon tests. The significance level was set at p < 0.05. Result: Semiology was more frequently offered only in the 4th semester (n = 40), followed by its offer in two semesters, the 4th and 5th and 3rd and 4th. Among the 226 schools, 142 integrated semiology into modules or axes (62.8%). Among the 117 schools that provided the semiology course load, its median was 240.0 hours (P25-75 = 165.4 - 338.2), with no statistical difference by geographic region, type of administration and time of existence of the course. The median of the theoretical course load [77.5 hours (P25-75 = 51.7 - 123.5)] was lower than the practical course load [147.0 hours (P25-75 = 64.5 - 180.0)], Z = - 3,99, p < 0,01. The median of the percentage of semiology course load during the course was 2.9% (P25-75 = 2.0 - 4.0). Conclusion: Semiology is more frequently offered in the 4th semester and its median course load is similar in Brazilian geographic regions and by school administration type and time of existence of the assessed schools.

Construction and application of intelligent outpatient pre-admission medical history collection system / 中华医院管理杂志

Digital and intelligent technology is an important driving force to promote the transformation and innovation of medical service mode and improve service quality. In February 2020, Peking Union Medical College Hospital established an intelligent outpatient pre-admission medical history collection system in order to improve the intelligent level of clinical application business system and the medical experience of outpatients.The system consisted of artificial intelligence capability layer, application service layer, capability resource layer and user application layer and hardware technology architecture. By docking with the hospital information system and using mobile terminal App, patients could submit pre-admission medical history information by themselves, and generate structured patient history for the visiting doctors to call. By November 2021, the pre-admission medical history collection system had covered 80% of the departments of the hospital, serving 1.68 million people in total, and the patient filling rate had reached 60%. The duration of patient′s medical history collection and the duration of doctor′s outpatient electronic medical record writing had been continuously shortened, greatly improving the efficiency of outpatient medical services.

A construção de competências nas etapas iniciais da formação médica: Um relato de experiência / The building of skills in the initial stages of medical training: An experience report

Introdução: A graduação em Medicina tem passado por diversas mudanças curriculares, com transferência gradativa do ensino tradicional para metodologias ativas, as quais preconizam a aprendizagem significativa e a participação ativa dos discentes. Orientado pelas Diretrizes Curriculares Nacionais vigentes, o curso de graduação em Medicina da Universidade Federal do Pampa (UNIPAMPA), contempla essa nova perspectiva formativa. Apresenta como foco as construções de competências médicas, desenvolvidas desde etapas iniciais do curso, com ênfase no vínculo entre teoria e prática. Método: O presente estudo aborda um relato de experiência e tem por objetivo refletir acerca da implementação da disciplina "Introdução à Psicologia e Habilidades Médicas" (IPHM). Resultados: Por meio das atividades do referido componente curricular, é ofertado desde o primeiro semestre o contato dos discentes com a entrevista médica, com ênfase na construção da anamnese e na compreensão dos aspectos relacionais e comunicacionais englobados. Ainda que outras instituições desenvolvam a construção de aspectos relacionados à anamnese médica em fases iniciais, o curso de Medicina da Unipampa apresenta inovações na forma como conduz esse trabalho, com emprego de metodologias ativas associadas às situações clínicas simuladas (Role-play), com foco tanto na redação, como nas relações interpessoais e qualidade da comunicação na relação médico-paciente. Conclusões: Por meio da abordagem dos desafios e potencialidades do processo de implementação do referido componente curricular, cumpre reconhecer a adequação e a pertinência da experiência, no sentido de estabelecer um espaço de construção de competências profissionais para a entrevista médica, em momento inicial da formação acadêmica.

Introduction: Graduation in Medicine has experienced several changes in the training curriculum, by changing from the traditional way of teaching to active methodologies, providing meaningful learning and active participation by students. Guided by the National Curriculum Guidelines, the undergraduate course in Medicine, from the Federal University of Pampa (Unipampa), contemplates this new formative perspective, through curricular innovations in the methodological and organizational fields. It focuses on the construction of medical skills, developed since the initial stages of the course, with emphasis on the link between theory and practice. Method: This study is an experience report, with a qualitative approach and aims to reflect on the implementation of the IPHM discipline. Results: Through the activities of this curricular component, student´s contact with the medical interview is offered in the first semester, emphasis on the construction off the anamnesis and the knowlegment of its relational and communicational aspects. Although other academies develop the construction of aspects related to medical anamnesis in early stages, the Unipampa's Medicine course introduced a inovation in the way that conducts it's work, using active methodologies associated with simulated clinical situations (Roleplay), focusing both writing, interpersonal relationship and quality of communication between doctor and patient. Conclusions: Through addressing the challenges and potentialities of the implementation process of the said curricular component, it is important to recognize the adequacy and relevance of the experience, in order to establish a space for the construction of professional skills for the medical interview, at the beginning of academic training.

Characteristics of gastric microbiota in children with Helicobacter pylori infection family history / 北京大学学报(医学版)

OBJECTIVE@#To explore the characteristics of gastric microbiota in children with and without (Helicobacter pylori, H. pylori) infection who had family history of H. pylori infection.@*METHODS@#Mucosal biopsy samples of the gastric corpus and gastric antrum were collected during the gastroscope. And the gastric mucosa flora's information of the two groups of children were obtained after sample DNA extraction, PCR amplification of the 16S ribosomal DNA (rDNA) V3-V4 region, high-throughput sequencing and data processing. All the samples with family history of H. pylori infection were divided into two groups, the H. pylori infection group (n=18) and the H. pylori non-infection group (n=24). Then the α-, β-diversity and bacteria abundance of the gastric microbiota were compared between the H. pylori infection and non-infection groups at different taxonomic levels. The differential microbiota was found out by LEfSe analysis, and then the function of microbiota predicted using phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) method.@*RESULTS@#There was statistically significant difference in α-diversity (P < 0.05) between the two groups, indicating that the H. pylori non-infection group had higher microbial richness than the H. pylori infection group. Moreover, the β-diversity was significantly different as well (P < 0.05), which meant that the microbiota composition of the two groups was different. At the phyla level, Proteobacteria, Firmicutes, Bacteroides, Actinobacteria, and Fusobacteria were dominant in the two groups. At the genus level, Bacteroides, Prevotella, Streptococcus, and Neisseria, etc. were dominant in the H. pylori non-infected group. Meanwhile, Helicobacter and Haemophilus etc. were dominant in the H. pylori infected group. LEfSe analysis showed that the relative abundance of Bacteroides etc. at the genus level in the H. pylori non-infected group was significantly higher than that in the H. pylori infected group. Functional prediction showed that Bacteroides were positively correlated with amino acid and vitamin metabolism, mitogen-activated protein kinase (MAPK), mammalian target of rapamycin (mTOR) signaling pathway and ansamycin synthesis pathway.@*CONCLUSION@#The gastric microbiota between H. pylori positive and H. pylori negative in children with family history of H. pylori infection is significant different. Some gastric microbiota, such as Bacteroides, may have a potential relationship with H. pylori infection in children.

Analysis of clinical data of 3 cases of hemophagocytic syndrome and literature review / 中国基层医药

Objective:To analyze the clinical characteristics, diagnosis, treatment and prognosis of three children with hemophagocytic syndrome (HPS) and provide diagnosis and treatment clues for reasonable treatment and prevention of serious complications and reduction of misdiagnosis and mistreatment.Methods:The clinical data of three children with HPS who received treatment in Taiyuan Maternal and Child Health Care Hospital from March 2018 to March 2020 were retrospectively analyzed. Related literature was retrieved. The clinical data of the three children were summarized to analyze the outcomes.Results:Fever (≥ 39 ℃) was the first symptom in all three cases. In the end, red blood cell line, white blood cell line, and platelet line were reduced to different degrees in all three cases. Hepatosplenomegaly was found in two cases. Transaminase highly increased in two cases, and slightly increased in one case. Ferritin greatly increased, fibrinogen decreased, and hypertriglyceridemia did not occur in all three cases. Two cases had skin rash during fever. Skin rash appeared late in one of them.All three cases had different degrees of lymphadenopathy. Bone puncture examination showed reticulocyte phagocytosis in bone marrow in one case and leishmania in bone marrow smear in another case. These two cases were cured and discharged. One case died of multiple organ failure due to rapid disease progression, and adrenal masses were found at autopsy.Conclusion:HPS has diverse clinical manifestations, complex etiology and different clinical prognoses. HPS should be considered in case of unexplained fever with hemocytopenia. The medical history and living history should be inquired in detail and relevant auxiliary examinations should be improved as soon as possible.

Sociodemographic and Maternal Risk Factors Associated with Psychomotor Retardation in Infants under Two Years Old in Tabasco / Factores de riesgo sociodemográficos y maternos asociados al retraso psicomotor en infantes menores de dos años en Tabasco / Fatores de risco sociodemográficos e maternos associados ao atraso psicomotor em crianças menores de dois anos em Tabasco

Abstract Introduction: Adequate psychomotor development during the first years of life significantly impacts the growth of each infant, so the timely detection of risk factors that affect this development is of vital importance. The objective was to determine sociodemographic and maternal factors associated with the presentation of psychomotor retardation in infants under two years old who attended the Centro de Rehabilitación y Educación Especial in Villahermosa (Tabasco, Mexico) in 2017. Materials and methods: An observational, retrospective study of cases and controls in infants under two years old. Data collection was performed using a questionnaire consisting of 45 questions, which included variables such as psychomotor retardation, prenatal, perinatal, and postnatal risk factors, that used Pearson's chi-square test and Fisher's exact test, with a significant correlation of p <.05 being accepted . Results: A low social class showed a significant relationship with psychomotor retardation (p =.000), while the presence of infections at a very young age in the newborn, a family history of psychomotor retardation, and a history of disease during pregnancy showed a value of p <.05. Conclusión: A low socioeconomic status, pregnancy-associated diseases such as malnutrition, high blood pressure, and traumatic accidents, as well as infectious diseases at birth were the main factors that conditioned psychomotor retardation.

Resumen Introducción: el adecuado desarrollo psicomotor en los primeros años de vida influye significativamente en el crecimiento de cada sujeto, por lo que la detección oportuna de factores de riesgo que lo afecten es de vital importancia. El objetivo fue determinar factores sociodemográficos y maternos asociados a la presentación del retraso psicomotor en infantes menores de dos años que acudieron al Centro de Rehabilitación y Educación Especial en Villahermosa (Tabasco, México) en el 2017. Materiales y métodos: estudio observacional, retrospectivo de casos y controles en infantes menores de dos años. Los datos se recolectaron mediante un cuestionario de 45 ítems, que incluyó variables como retraso psicomotor, factores de riesgo prenatales, perinatales y posnatales. Se emplearon las pruebas chi cuadrado de Pearson y la prueba exacta de Fisher. Se aceptó una correlación significativa de p<0.05. Resultados: el estrato social bajo mostró una relación significativa con el retraso psicomotor (p = 0.000), así como la presencia de infecciones a una edad muy temprana en el recién nacido, el historial de antecedente familiar y el antecedente de enfermedad en el embarazo (p<0.05). Conclusión: un estatus socioeconómico bajo, enfermedades asociadas al embarazo como malnutrición, hipertensión arterial y accidentes traumáticos, además de las enfermedades infecciosas al nacer, fueron los principales factores que condicionaron el retraso psicomotor.

Resumo Introdução: o adequado desenvolvimento psicomotor nos primeiros anos de vida impacta significativamente no crescimento de cada sujeito, pelo que a detecção oportuna de fatores de risco que o afetem é de vital importância. O objetivo foi determinar fatores sociodemográficos e maternos associados à apresentação do atraso psicomotor em crianças menores de dois anos que acorrem ao Centro de Reabilitação e Educação Especial em Villahermosa (Tabasco, México) em 2017. Materiais e métodos: estudo observa-cional, retrospectivo de casos e controles em crianças menores de dois anos. A recolecção de dados se realizou mediante um questionário de 45 itens o qual incluiu variáveis como atraso psicomotor, fatores de risco pré-natais, perinatais, e pós-natais, empregando as provas qui-quadrado de Pearson, prova exata de Fisher. Se aceitou uma correlação significativa de p<.05. Resultados: o estrato social baixo mostrou relação significativa com o atraso psicomotor (p=.000); também a presença de infeções a uma idade muito precoce no recém-nascido, o historial de antecedente familiar e antecedente de doença na gravidez (p<.05). Conclusão: o status socioeconómico baixo, doenças associadas à gravidez como subnutrição, hipertensão arterial e acidentes traumáticos, para além das doenças infeciosas ao nascer, foram os principais fatores que condicionaram o atraso psicomotor.

Um roteiro de entrevista clínica centrada na pessoa para a graduação médica / A patient-centered clinical interview script for medical undergraduate teaching / Un guion de entrevista clínica centrado en la persona para el pregrado en medicina

O ensino de habilidades de comunicação clínica na graduação médica encontra nos princípios e componentes do Método Clínico Centrado na Pessoa (MCCP) uma referência importante para a definição de suas competências. No entanto, mesmo tendo contato com o MCCP em sua formação, é frequente que estudantes de medicina recorram à utilização da anamnese tradicional centrada na agenda médica como um roteiro mais seguro para realização de suas entrevistas. Propomos, como uma hipótese para essa dificuldade dos estudantes, a falta de uma tradução do MCCP em um roteiro padronizado de entrevista médica, especialmente para ensino na graduação. Neste relato, a partir de modelos de entrevista clínica centrada na pessoa (ECCP) selecionados da literatura internacional, apresentamos a primeira etapa de um roteiro de ECCP original, adaptado ao cenário brasileiro. O objetivo deste relato é oferecer uma referência de fácil utilização em língua portuguesa e que possa ser aprimorada pelos profissionais envolvidos com o ensino de comunicação clínica na educação superior no Brasil. Estudos empíricos ainda são necessários para endossar uma utilização mais ampla da proposta aqui apresentada

The teaching of clinical communication skills in medical undergraduate studies finds in the principles and components of the Patient-Centered Clinical Method (PCCM) an important reference to define its competences. However, even having contact with the PCCM in undergraduate teaching, medical students often resort to the traditional medical doctor-centered anamnesis as a safer script for conducting their interviews. We propose, as a hypothesis for this difficulty, the absence of a PCCM translation into a standardized medical interview script, especially for undergraduate teaching. In this report, based on patient-centered clinical interview (PCCI) models selected from the international literature, we present the first step of an original PCCI script, adapted for the Brazilian scenario. This report aims to provide a user-friendly reference in Portuguese that can be improved by professionals involved with the teaching of clinical communication skills in higher education in Brazil. Empirical studies are still needed to support wider use of the proposal presented here.

La enseñanza de las habilidades de comunicación en el pregrado en medicina encuentra en los principios y componentes del Método Clínico Centrado en la Persona (MCCP) una referencia importante para la definición de sus competencias. Sin embargo, incluso teniendo contacto con el MCCP en su formación, es frecuente que los estudiantes de medicina recurran al uso de la anamnesis tradicional centrada en la agenda médica, como un guion más seguro para realizar sus entrevistas. Proponemos, como una hipótesis para esta dificultad de los alumnos, la falta de una traducción del MCCP en un guion estandarizado de entrevista médica, especialmente para la enseñanza en el pregrado. En este relato, a partir de modelos de entrevista clínica centrada en la persona (ECCP) seleccionados de la literatura internacional, presentamos el primer paso de un guion de ECCP original, adaptado al escenario brasileño. El objetivo de este relato es ofrecer una referencia en lengua portuguesa de fácil utilización y que puede ser mejorada por los profesionales involucrados en la enseñanza de la comunicación clínica en la educación superior en Brasil. Todavía se necesitan estudios empíricos para respaldar un uso más amplio de la propuesta que aquí se presenta

O Ensino da Anamnese Assistido por Tecnologias Digitais durante a Pandemia da Covid-19 no Brasil / Digital Technology-Assisted Teaching of Anamnesis during the Covid-19 Pandemic in Brazil

Resumo: Introdução: Em dezembro de 2019, na China, surgiu o primeiro caso de infecção da Sars-CoV-2, causadora da Covid-19. Em março de 2020, após se alastrar pelos continentes, a Organização Mundial da Saúde conferiu característica de pandemia. Para tentar conter o avanço, foi criada a política de distanciamento social, responsável pela interrupção de inúmeras atividades, incluindo aulas presenciais. Assim, ampliou-se a busca por meios de ensino remoto, a fim de amenizar os prejuízos causados na educação. Nesse ínterim, a Universidade Federal de Alagoas propôs realizar a monitoria on-line como forma de promover interação entre estudantes e docentes na pandemia. Relato de Experiência: A construção do curso ocorreu de forma remota por meio de plataformas digitais, como Google Meets® e portal do serviço de conferência web da Rede Nacional de Ensino e Pesquisa (RNP). Foram 54 inscrições de alunos de Medicina, e 38 (70,3%) cumpriram os requisitos para certificação e finalizaram. Produziram-se 22 podcasts, hospedados nas plataformas Anchor® e Spotify®, além de seis formulários do Google® com questões acerca dos conteúdos dos podcasts. Utilizaram-se as plataformas Kahoot®, um jogo com questões para aumentar a interação e o Padlet®, um "mural virtual" no qual eram postados conteúdos do curso. Discussão: A implantação das novas Diretrizes Curriculares Nacionais dos Cursos de Graduação Medicina (DCN) instigou nos estudantes autonomia no aprendizado, conferindo espaço para a inserção de tecnologias na educação. Apesar da insuficiência para sanar os prejuízos causados na educação pela pandemia, essas tecnologias conferem aos professores, aos alunos e às instituições de ensino a capacidade de adequação aos meios disponíveis para minimizar prejuízos. Conclusão: A monitoria on-line permitiu que, mesmo um assunto predominantemente prático como a anamnese, fosse discutido e praticado graças ao suporte tecnológico. Percebe-se, portanto, efetividade na utilização de tecnologias no processo de ensino-aprendizagem quando se utilizam plataformas interativas.

Abstract: Introduction: The first case of SARS-CoV-2 virus infection, which caused COVID-19, occurred in China in December 2019. By March 2020, having spread across continents, the disease was officially declared as a pandemic by the World Health Organization. In an attempt to contain the advance of infection, a policy of social distancing was introduced, which implied in the interruption of numerous activities, including face-to-face classes. Hence the demand for means of distance learning expanded in order to mitigate the harm caused in education. In the meantime, the Federal University of Alagoas proposed to carry out online monitoring as a way to promote student-teacher interaction during the pandemic. Experience Report: The course was constructed remotely on digital platforms, such as Google Meets® and National Teaching and Research Network (RNP) online video conference portal. Fifty-four medical students enrolled, of whom 38 (70.3%) met the certification requirements for certification and completed the course. Twenty-two podcasts were produced, hosted on the Anchor® and Spotify® platforms, in addition to six Google® forms with questions about the contents of the podcasts. Other resources used included Kahoot® platforms, a quiz to increase interaction, and Padlet®, a "virtual wall" for posting course content. Discussion: The implementation of the new National Curricular Guidelines for Undergraduate Medicine Courses (DCN) triggered greater student autonomy in learning, opening the way for the use of technologies in education. Although insufficient to remedy the damage caused in education by the pandemic, these technologies offer teachers, students and educational institutions the ability to adapt to available methods and minimize the harm. Conclusion: Online monitoring represents technological support that has allowed for even a predominantly practical subject, such as anamnesis, to be discussed and practiced. There is, therefore, demonstrable effectiveness in the use of technologies applied to the teaching-learning process, when using interactive platforms.

Whole exome sequencing in a pedigree with ankylosing spondylitis / 中国骨伤

OBJECTIVE@#To choose the disease-causing gene in a Chinese pedigree with ankylosing spondylitis (AS) by whole-exome sequencing (WES), and provide theory basis for mechanism of disease.@*METHODS@#Clinical data of AS pedigree were collected, including 2 males, the age were 48 and 18 years old, the course of disease were 23 and 4 years. Whole blood genomic DNA of AS was extracted to perform whole exome sequencing, the results were compared with human databases, common variations which had been reported were wiped out, then non synonymous single nucleotide variants(SNVs) from the family members were combined, and candidate genes was selected initially.@*RESULTS@#Totally 80 G data was obtained from AS family with high quality.By comparing results between patient and normal subject, and filtering with number of biological database, the result showed heterozygous mutation of JAK2 gene 12 exon c.1709 A>G (p.Tyr570Cys) may be the potential disease-causing gene. The variant c.1151T>C of MUC3A gene may be one of the causes of intestinal symptoms in the family members.@*CONCLUSION@#It is feasible to find t candidate gene mutations of AS by Exon sequencing. The mutation c.1709 A>G in gene JAK2 identified by whole exome sequencing might be the pathogenic mutation in this AS pedigree.

Enfoque del paciente con adenopatías generalizadas. Importancia de la estrategia didáctica del estudio de casos clínicos: a propósito de un paciente con linfoma de Hodgkin asociado a una infección por el virus de Epstein-Barr

Se muestra el caso de un paciente con 56 años de edad, con un síndrome adenomegálico generalizado que presentó un linfoma de Hodgkin de celularidad mixta, asociado al virus de Epstein-Barr. El paciente previo al inicio del linfoma presentó episodios prolongados de estrés emocional, lo que posiblemente contribuyó a la disminución de la vigilancia inmunológica. El caso fue abordado por los estudiantes de quinto semestre en la asignatura Acto médico, una estrategia didáctica interdisciplinaria. Este artículo presenta los aspectos a tener en cuenta en el enfoque clínico de los pacientes con adenopatías desde una perspectiva integradora de la inmunología, la clínica y los diagnósticos diferenciales. Se resalta el valor del estudio de los casos clínicos con varios métodos diagnósticos como estrategia didáctica. Finalmente, se realiza una revisión de la literatura sobre el linfoma Hodgkin orientada al papel en el que participa la infección por el virus de Epstein-Barr, relacionada con la inmunosupresión por estrés.

SUMMARY We present the case of a 56-year-old patient with a generalized adenomegalic syndrome who presented a mixed cellular Hodgkin's lymphoma associated with Epstein Barr Virus. The patient had had great emotional stress prior to the onset of lymphoma, which possibly contributed to the decrease in immunological surveillance. The case was addressed by the students of the fifth semester in the subject "Medical Act", an interdisciplinary didactic strategy. We present the aspects to be taken into account in the approach of the clinician of patients with adenopathies from an integrative perspective of immunology, clinical and differential diagnoses; and the value of the study of clinical cases with several diagnostic approaches as a didactic strategy is highlighted. Finally, we present a literature review about Hodgkin lymphoma and the role which plays stress related Epstein Barr Virus infection.

Henrique Dumont: how a traumatic brain injury contributed to the development of the airplane / Henrique Dumont: como um traumatismo cranioencefálico contribuiu para o desenvolvimento do avião

ABSTRACT The life and death of Henrique Dumont (1832-1892) is little known, being usually remembered as Alberto Santos-Dumont's father. This report describes the history of this Brazilian engineer, also known as the King of Coffee, who achieved enormous business success and fortune in the late nineteenth century. In 1890, during the inspection of his farm, the world's largest coffee plantation at that time, he fell from a carriage, which left him a hemiplegic. This forced him to sell the farm and move to France for treatment. Before his death two years later, he gave his 18-year-old son bits of advice, and distributed his inheritance, which allowed Alberto to study in Paris and finance his experiments that would culminate in the development of the airplane. The diagnostic and therapeutic possibilities are also discussed.

RESUMO A vida e especialmente a morte do brasileiro Henrique Dumont (1832-1892) são pouco conhecidas, sendo geralmente lembrado como pai de Alberto Santos Dumont. Relatamos a história deste engenheiro que obteve enorme sucesso empresarial no final do século XIX, sendo denominado Rei do Café. Em 1890, durante a inspeção da sua fazenda, maior cafeicultura do mundo na época, caiu da charrete e ficou hemiplégico. Isso o fez vender a fazenda e buscar tratamento na França, trazendo o primeiro automóvel do Brasil ao retornar. Antes de morrer dois anos após o acidente, deu valorosos conselhos e distribuiu sua herança ao filho Alberto, então com dezoito anos de idade, que pôde assim estudar em Paris e financiar seus experimentos que culminariam no desenvolvimento do avião. São discutidas e contemporizadas as possibilidades diagnósticas e terapêuticas relacionadas ao déficit neurológico.

Study on occurrence of masked hypertension and the degree of target organ damage in the population with family history of hypertension / 中国医师杂志

Objective@#To investigate the occurrence of masked hypertension (MH) and the degree of damage to target organs in people with family history of hypertension.@*Methods@#987 cases of family history of hypertension who had been examined in our hospital from January 2017 to November 2017 were selected as observation group with the approval of hospital ethics committee. At the same time, 987 subjects without family history of hypertension who had been examined in our hospital during the same period were selected as control group. The incidence of masked hypertension, left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) were observed.@*Results@#The incidence of hypertension and masked hypertension in the observation group was significantly higher than that in the control group (P<0.05). LVMI and IMT in patients with masked hypertension were significantly higher than those in normal blood pressure group. LVMI and IMT in patients with hypertension were higher than those in patients with masked hypertension and normal blood pressure group. The LVMI and IMT of patients with family history of masked hypertension were higher than those without family history of masked hypertension.@*Conclusions@#Family history of hypertension can increase the incidence of masked hypertension and organ damage of patients. The monitoring of masked hypertension should be strengthened for those with family history of hypertension.

Study on occurrence of masked hypertension and the degree of target organ damage in the population with family history of hypertension / 中国医师杂志

Objective To investigate the occurrence of masked hypertension (MH) and the degree of damage to target organs in people with family history of hypertension.Methods 987 cases of family history of hypertension who had been examined in our hospital from January 2017 to November 2017 were selected as observation group with the approval of hospital ethics committee.At the same time,987 subjects without family history of hypertension who had been examined in our hospital during the same period were selected as control group.The incidence of masked hypertension,left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) were observed.Results The incidence of hypertension and masked hypertension in the observation group was significantly higher than that in the control group (P ＜ 0.05).LVMI and IMT in patients with masked hypertension were significantly higher than those in normal blood pressure group.LVMI and IMT in patients with hypertension were higher than those in patients with masked hypertension and normal blood pressure group.The LVMI and IMT of patients with family history of masked hypertension were higher than those without family history of masked hypertension.Conclusions Family history of hypertension can increase the incidence of masked hypertension and organ damage of patients.The monitoring of masked hypertension should be strengthened for those with family history of hypertension.