ABSTRACT
In this study, the origin and causes of cooked traditional Chinese medicine powder were reviewed, and a comprehensive analysis was made for the time background of modern traditional Chinese medicine formula granules and the future development trend, in order to provide reference for application and promotion of traditional Chinese medicine formula granules. By reference to ancient medical books of previous dynasties, a system review was conducted for infancy, formation, maturity and transition of cooked traditional Chinese medicine powder, and a comprehensive analysis was made for the six factors of cooked traditional Chinese medicine powder's maturity in the Song Dynasty. Efforts were made to collect domestic and foreign research literatures of modern formula granules, understand the detailed development, and conduct an objective analysis of the current clinical application of modern formula granules. According to the comparative analysis for the application characteristics of cooked traditional Chinese medicine powder and modern formula granules, ①the popularity of cooked traditional Chinese medicine powder in the Song Dynasty has six factors: soaring numbers of medical students and medical practitioners, high medical expenses due to huge army, rapid population growth, frequent epidemics and increasing diseases, and insufficient finances of central and local governments. ②On the basis of clinical application characteristics of traditional Chinese medicine formula granules, traditional Chinese medicine formula granules contain extracted and concentrated effective components, which guarantee the curative effect, meet modern people's demands for "quick, simple and convenience" traditional Chinese medicine decoctions, show a relatively high cost performance; however, formula granules are restricted by their varieties and lack unified quality control standards, and single-extract formula granules have not synergy and attenuation effects of combined traditional Chinese medicine decoctions, which also restricts its clinical application and promotion. ③Both have advantages in the process of clinical application, and shall be used based on syndromes. In conclusion, traditional Chinese medicine formula granules do not have disadvantages of "difficult, complicated, turbid and disorderly" cooked traditional Chinese medicine powder, and solve such problems as "inflexibility, expensiveness, restriction, disorder and inefficacy", which is the important basis for promoting traditional Chinese medicine formula granules.
ABSTRACT
Metabonomics is an emerging "omics" following genomics, proteomics, and transcriptomics. It has been widely used in the field of life science, and shows hopeful prospects. The principle of metabonomics is to understand the physiological and pathological state of the organism by comprehensive analysis of the metabolites with low relative molecular weight after external stimuli. In the present, metabonomics is widely used in the studies on traditional Chinese medicine (TCM), and provides the strong technical support for the TCM safety evaluation, the material basis and mechanism of Chinese medicinal formula, and understanding the recognition of TCM syndrome and sign.
ABSTRACT
Objective To compare the clinical efficacies of vasiculation moxibustion with pastes prepared in different ways and at different acupoint groups in treating allergic rhinitis due to deficient cold of lung qi. Method Eighty subjects were randomized into 4 groups, 20 in each group. Raw Bai Jie Zi (Semen Brassicae) was used in the vesiculation paste for group 1 and 2;stir-baked Bai Jie Zi (Semen Brassicae) was used for group 3 and 4. In group 1 and group 3, bilateral Feishu (BL 13), Fengmen (BL12), and Gaohuang (BL 43) were selected; in group 2 and group 4, bilateral Dazhu (BL11), Geshu (BL17), and Shenshu (BL23) were selected. The symptom and sign scores were compared before and after intervention. Result There were significant differences in comparing the symptoms and signs among the four groups (P＜0.05), and paired comparisons showed that the therapeutic efficacies of group 1 and group 3 were significantly higher than that of group 2 and group 4 (P＜0.05), while the differences in the therapeutic efficacy between group 1 and group 3, group 2 and group 4 were statistically insignificant (P>0.05). Conclusion Vesiculation moxibustion at the point group of Fengmen (BL12), Feishu (BL13), and Gaohuang (BL43) can markedly improve the symptoms and signs of allergic rhinitis due to deficient cold of lung qi;raw and stir-baked Bai Jie Zi (Semen Brassicae) can work equally in vesiculation paste for allergic rhinitis.
ABSTRACT
An animal model to initiate anl oxidative stress in brain has been successfully applied in vitro condition. Temporary brain ischemia is conducted by two carotid arterie occlusion for 20 min. Then a reperfusion is followed for 20 min. aiming to produce oxidative damage. MDA measurements are used to assess the levels of brain damage and protective effects of studied extracts. One formulation for "activating the blood and clearing the obstruction" has been tested for the protective activity against the ischemia/repelfusion-induced injuries to brain. The extract was given to mice in doses of 200, 300 and 500mg/kg for 10 continuous days prior to the induction of brain ischemia. This application showed a remarkable protective effects by limiting the elevated MDA levels in brain homogenates, resulted from ischemia/reperfusion (P<0.001). Corresponding to the increased oxidative stress in ischemia/reperfusion, SOD activity (an antioxidant enzyme) was found to be reduced in this model, while the studied extract almostly reversed the decrease of SOD activity when it was given to mice in the dose of 500 mg/kg body weight