ABSTRACT
El vitiligo es una enfermedad pigmentaria cutánea adquirida e idiopática, debido a múltiples factores causales que ocasionan la destrucción o inactivación funcional del melanocito. Ha habido numerosas alternativas terapéuticas a lo largo de los años como: tratamientos tópicos, PUVA (psoralenos más luz ultravioleta) o fototerapia UVB de banda estrecha; sin embargo, muchos no responden a estos tratamientos médicos. El tratamiento quirúrgico del vitiligo se indica cuando las máculas hipo o amelanóticas, se localizan en zonas mal respondedoras o tras fracaso de los tratamientos convencionales. Se trata de favorecer la re-pigmentación de las lesiones, a través del trasplante de melanocitos desde las áreas pigmentadas normales. El objetivo de esta revisión, es el de analizar el estado actual del tratamiento quirúrgico del vitiligo y en concreto, del trasplante de melanocitos autólogos.
Vitiligo is an idiopathic and acquired disorder that affects the pigmentation of the skin due to several factors that cause the destruction of melanocytes. There are numerous therapeutic alternatives, topical treatments, PUVA or narrowband UVB phototherapy. However, many patients do not respond to these medical treatments. Surgical treatment of vitiligo is indicated when depigmented macules are located in poorly responsive or after failure of conventional treatments. It seeks to encourage repigmentation of lesions by transplantation of melanocytes from normal pigmented areas. The objective of this review is to analyze surgical treatment of vitiligo and especially autologous melanocyte transplantation.
ABSTRACT
Objective To investigate the clinical efficacy of autologous cultured pure melanocytes for treatment of patients with acral vitiligo.Methods Sixty-two (including 96 skin lesions) patients with acral vitiligo were divided into two groups by treatment methods:narrow-spectrum midwave ultraviolet ray treatment group (group A) 50 skin lesions and autologous cultured pure melanocytes group (group B) 46skin lesions.The clinical efficacy between the two groups was compared.The melanocyte division time (MDT) was calculated.Results The effective rate in group B was significantly higher than that in group A [71.7％(33/46) vs.36.0％(18/50),P＜ 0.05].No significant relationship was found between clinical efficacy with age,position of skin lesions and course of disease in group B (P ＞0.05),however,the clinical efficacy was significantly related with MDT in group B (P＜ 0.05).Conclusion Autologous cultured pure melanocytes is an effective method for the treatment of acral vitiligo,and the MDT plays a major role in affecting its clinical efficacy.