Progress of the study on cytosine arabinoside in the treatment of acute leukemia in children / 中华实用儿科临床杂志

Cytosine arabinoside (Ara-C) is one of the key chemotherapy drugs comprising all stages combined protocols during long-term chemotherapy for children with acute leukemias,which demonstrated its efficacy and safety.Along with the progress of basic and clinical researches,in Ara-C clinical dose and treatment,prevention of adverse reactions,relationship between the drug metabolism and long-term clinical results,and new nucleoside drugs have achieved remarkable results.This paper on the above fields of research,progress and trends,briefly summarized as follows.