ABSTRACT
The risk of cardiovascular disease increases with obesity and thereby leads to increase in mortality in obese persons. Excess of adipose tissue causes cardiovascular abnormalities through endothelial dysfunction and insulin resistance. We wanted to study different risk factors for cardiovascular diseases by evaluating anthropometric measurements and lipid profiles in metabolic obese normal weight subjects with cardiovascular diseases. METHODSThis case control study was conducted in Jawaharlal Nehru Medical College, AVBRH Hospital, Wardha. After taking clearance from the Institutional Ethical Committee, 200 cases with cardiovascular disease, and 200 controls without the cardiovascular disease, were selected and their lipid profile and anthropometric measurements were evaluated and compared gender wise. RESULTSThere was significant association of weight in females (56.81 ± 3.94), BMI in males (24.32 ± 0.65), cholesterol in females (177.72 ± 16.93), height (163.15 ± 10.94 in males and 154.81 ± 3.76 in females), lean mass (48.92 ± 7.22 in males and 37.05 ± 7.14 in females), % body fat (22.79 ± 7.23 in males and 35.04 ± 9.73 in females), waist circumference (102.93 ± 1.12 in males and 93 ± 0 in females), Serum HDL (30.12 ± 6.98 in males and 33.45 ± 8.34 in females), triglyceride (156.84 ± 7.28 in males and 161.45 ± 10.34 in females) in both males and females. Whereas weight in males, BMI in females, cholesterol in males and serum LDL in both male and female had a P-value of greater than 0.05 and shows no possible association of these factors in the MONW subjects as a cause of cardiovascular diseases. CONCLUSIONSIn this study, we found that there is a significant association between some factors of anthropometric measurements and lipid profile with MONW. Hence, it was concluded that an early screening will help in identifying persons with high risk of cardiovascular disease, and can be a major contributor in prevention of cardiovascular disease.
ABSTRACT
The evaluation of coronary artery disease (CAD) concerning the metabolic status and body mass index (BMI) is poorlystudied. This study was designed to observe the relationship between insulin resistance (IR) and the severity of CADon the basis of the metabolic and phenotypic status in stable-angina patients. A cross-sectional study was conductedon 532 patients with stable angina and coronary angiogram was done to diagnose the CAD for all. Determination ofmetabolic obesity was done using the National Cholesterol Education Program-Adult Treatment Panel III criteria.Phenotypic obesity was defined as BMI ≥ 25 kg/m2. Homeostasis model assessment IR in correlation with the severityof CAD was measured using SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for theTreatment of Narrowed Arteries) Score. The average age of the patients was 57.58 ± 10.40 years, and 69.4% weremales. Out of 532 subjects, 51.3% were hypertensive, 14.5% were smokers, 29.1% consumed alcohol, 49.3% weremetabolically obese, and 50% were phenotypically obese. Increase in IR increased the risk of severity of CAD inmetabolically obese subjects (OR = 2.51, p = 0.048). In the phenotypically obese group, the relationship between IRand the severity of CAD was not statistically significant (OR = −2.19, p = 0.08). The study concludes that the increasedIR increases the risk of severity of CAD in metabolically obese subjects.