ABSTRACT
For resectable gastric cancer, although radical surgery is still the main treatment, methods of operation and the curative effect of operation are still in the stage of exploration for metastatic gastric cancer. Radiotherapy, chemotherapy and molecular targeted therapy also play an important role in prolonging the survival period of patients with gastric cancer. Postoperative radiotherapy and chemotherapy can prolong the survival time, but for patients with locally advanced gastric cancer, the preoperative radiotherapy and chemotherapy can also further improve the survival period of patients compared with direct operation. In addition, with the development and using of molecular targeted drugs, such as antiangiogenic agents, immunosuppressive drugs and so on, the survival period of patients with gastric cancer has been further extended.
Subject(s)
Humans , Antineoplastic Combined Chemotherapy Protocols , Gastrectomy , Neoadjuvant Therapy , Splenic Neoplasms , Stomach Neoplasms , Drug TherapyABSTRACT
Objective:To examine metastatic gastric cancer patients who underwent surgery after chemotherapy and to determine the factors affecting survival. Methods:Clinical data on metastatic gastric cancer patients who underwent surgery after chemotherapy were retrospectively analyzed. The overall survival data were evaluated through the Kaplan-Meier method, Log-rank test, and Cox haz-ards regression. Results:The median age was 46 (22~74), and the median overall survival rate (OS) was 19 months (4~59 months). Response to chemotherapy (23.0 m for PR and 14.5 m for SD, P=0.045) and resection of the primary tumor (23.0 and 5.5 m, respective-ly, P=0.017) affected OS. No single factor was related to OS according to Cox regression. Conclusion:Surgical removal of the primary tumor is recommended for metastatic gastric cancer patients with positive response to chemotherapy and with a primary tumor that can be resected.
ABSTRACT
Majority of metastatic stomach tumor is direct invasion from adjacent malignant lesions such as pancreatic carcinoma, hepatoma, colonic carcinoma which invade the stomach via gastrocolic ligament. Otherwise, metastatic involvement of the stomach as a result of solid tumors of extra-gastrointestinal origin is a rare occurrence, in about 0.2% to 1.7% of patients dying of solid tumors. The tumors which were most commonly reported hematogenous metastatic malignancy of the stomach are melanoma, lung carcinoma, breast carcinoma. We have experienced an unusual case in which a metastatic gastric germ cell tumor presented as an upper gastrointestinal bleeding in a 29-year-old man. He was hospitalized with complaints of melena and severe anemic appearance. We performed gastroscopy which revealed an fungating mass covered with dark pigmentation at the anterior wall of lower body of the stomach. Pathologic findings of the biopsy showed a metastatic mixed germ cell tumor of the stomach. We report this unusual metastatic mixed germ cell tumor of the stomach with a review of literatures.
Subject(s)
Adult , Humans , Biopsy , Breast Neoplasms , Carcinoma, Hepatocellular , Colon , Gastroscopy , Germ Cells , Hemorrhage , Ligaments , Lung , Melanoma , Melena , Neoplasms, Germ Cell and Embryonal , Pigmentation , Stomach , Stomach NeoplasmsABSTRACT
Blood-borne metastatic cancer of the stomach is a rare occurrence according to a number of reports in the literature. Morever, it is extremely rare that gastric metastasis is man- ifested during life and most metastatic gastric tumors have been found at autopsy. The tumors most commonly reported to metastasize to the stomach include melanoma, breast carcinoma, and lung carcinoma. The frequency of metastatic gastric cancer from small cell lung cancer is 0.2-0.5% in the world literature. In Korea, there has been only one case reported on metastatic gastric cancer from small cell lung cancer. A 53-year-old man who had primary small cell lung carcinoma with brain metastasis complained of nausea, vomiting, and poor oral intake, An esophagogastroduodenoscopy revealed two submucosal tumors in the fundus and the mid body of the stomch. Pathologic examination revealed submucosal infiltration of small cell carcinoma. We report a case of metastatic gastric cancer, from small cell lung cancer that could be diaignosed during the subjectis followed by review of the life, literature.
Subject(s)
Humans , Middle Aged , Autopsy , Brain , Breast Neoplasms , Carcinoma, Small Cell , Endoscopy, Digestive System , Korea , Lung , Melanoma , Nausea , Neoplasm Metastasis , Small Cell Lung Carcinoma , Stomach , Stomach Neoplasms , VomitingABSTRACT
Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of the stomach secondary to lung carcinoma were diagnosed by gastroscopy. The first patient was a 66-year-old man who had primary lung carcinoma with multiple bone and subcutaneous metastases. Gastroscopy showed multiple submucosal tumors with central umbilications in the fundus and in the upper body of the stomach. Pathologic examination revealed massive submucosal infiltration and conical shaped and scanty deep mucosal infiltration of undifferentiated small cell carcinoma suggestive of metastatic involvement. The second patient was a 68-year-old man who had primary lung carcinoma with brain metastasis. Gastroscopy showed a large fungating mass in the greater curvature side of the stomach. Pathologic examination revealed poorly differentiated squamous cell carcinoma. We report the two cases of metastatic gastric cancer from lung carcinoma with the literature review.