ABSTRACT
Objective To investigate the effect of DSG biologic information infrared liver disease therapy instrument(BILT liver disease therapy instrument)on liver microcirculations in mice.Methods Liver fibrosis was induced in 40 SPF mice which were randomized into 4 groups:without irradiation group,coht light irradiation group,infrared light irradiation group and BILT group(10 in each group).Twenty healthy mice were taken as the control.Liver blood flow of each group was observed by laser-Doppler flow instrument,and blood flow rate of liver microcirculation in each group was observed by intravital microscopy.Pathological examination and serum biochemistry were also performed.Results In fibrosis mice,the liver blood flow in average of BIUF group Was higher than that of without irradiation group(P=0.004),while comparing with without irradiation group there were no significant differences in liver blood flows of the cold light irradiation group and infrared light irradiation group(P=0.713 and 0.465).Red blood cell velocity of microvessels in average of the healthy group(without irradiation)wag higher than that in the without irradiation group offibrosis mice(P=0.001),and it in the BILT group(fibrosis mice)Was also higher than those in other groups of fibrosis mice(P=0.004,0.020 and 0.030).For fibrosis mice,the average AST in BILT group was lower than that in the without irradiation group(P=0.027),and the difference in hydroxyproline(Hyp)levels between the groups was not of statistical significance(P=0.433).Conclusion BILT liver disease therapy instrument can improve the liver microcir-culation,reduce AST level and improve liver pathological state in mouse with fibrosis.
ABSTRACT
Objective To explore the relations among blood lipid,blood rheology and microcirculation of bulbar conjunctiva of model rats of diabetesⅡwith heart blood stasis syndrome.Methods The rats were fed with high fat and caloric feed.Intraperitoneal injection of streptozotocin(STZ)in small dosage was applied to make the model of diabetesⅡ.Then the model of heart blood stasis syndrome was made through introperitoneal injecting dexamethasone and adrenalin.Eight hours after empty stomach,the rats were anaesthetized to measure the microcireulation of bulbar conjunctiva and test the blood lipid and carotid blood rheology.Results The indices of blood lipid,blood rheology and bulbar eonjunetiva microcirculation of model rats were all changed to abnormal,tallying with the changes of cardiovascular complications of diabetes.