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Objective To explore the feasibility and accuracy of sex determination by morphology of the distal humerus in North China population. Methods Observing sexually dimorphic differences of olecranon fossa shape, trochlear symmetry, trochlear constriction and angle of medial epicondyle. Each characteristic was divided into three categories: male, unknown and female. The morphological characteristics of the humerus of 70 individuals (35 males and 35 females) from the Ming and Qing Dynasties in North China were counted to compare the occurrence rate of different categories of distal humeral morphology and the accuracy rate of sex determination. Results There were statistically significant differences in the performance of the four traits of the distal humerus between males and females. The accuracy rate of angle of medial epicondyle was the highest at 76%, while the lowest accuracy rate of trochlear constriction was only 52%. The accuracy of the combined four traits was higher than the single ones, with an accuracy rate of 76% (83% for males and 68% for females). Conclusion Distal humerus morphology can be used to determine sex when skulls and pelvis are absent.
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Objective:To systematically evaluate the efficacy and safety of Xiaoxuming Decoction combined with conventional western medicine for acute ischemic stroke (AIS).Methods:Randomized controlled trials of Xiaoxuming Decoction combined with conventional western medicine on AIS were retrieved from various databases including CNKI, SinoMed, WanFang, VIP, The National Library of Medicine (MEDLINE), Excerpt Medica Database (EMBASE), the Cochrane Central Register of Controlled Trials (CENTRAL) with the deadline of March 31th, 2021. The risk of bias of included trials was assessed in the light of the criteria recommended by the Cochrane Handbook 5.0.1 for Systematic Reviews of interventions. Data were retrieved and analysed by Review Manager 5.3 software.Results:Thirteen qualified trials with 1 007 patients were included, with the control group given conventional western medicine ( n=488) and the treatment group on the basis of the CG adding Xiaoxuming Decoction ( n=519). The risk of bias was general high among the included studies. Meta analyses showed that Xiaoxuming Decoction combined with conventional western medicine on AIS was significantly better to attenuate NIHSS scores and improve clinical effective rate than the routine treatment of western medicine, with MD=-2.51, 95% CI [-3.55, -1.47], P<0.05 and RR=1.14, 95% CI [1.07, 1.21], P=0.07. Two articles truthfully reported and recorded the incidence rate of total adverse events with 3.45% and 6.82%. Conclusion:Current evidence indicates that treating acute ischemic stroke with Xiaoxuming Decoction combined with conventional western medicine can improve the clinical efficacy and attenuate NIHSS scores.
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Humans , Acupuncture , Acupuncture Points , Acupuncture Therapy , Arthralgia , Breast Neoplasms/therapy , MoxibustionABSTRACT
The relevant provisions of bloodletting for expelling pathogens are collected from the works of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using frequency analysis, the bloodletting device, bloodletting location, bloodletting volume, the related pathogens and indications are compared between these two times so that the evidences could be provided for the inheritance and development of the academic thought of bloodletting for expelling pathogens. It is found that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing Dynasties and
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Acupuncture Points , Bloodletting , China , Medicine, Chinese Traditional , Meridians , NeedlesABSTRACT
@#AIM: To explore the effect of fundus laser combined with Qi Ming granule on diabetic retinopathy in stage Ⅲ.<p>METHODS: Fifty six patients with Ⅲ stage diabetic retinopathy who were treated in our hospital from December 2017 to June 2018 were divided into control group(28 cases)and observation group(28 cases)according to the treatment method. The control group was treated with panretinal photocoagulation. The observation group was treated with Qi Ming granule combined with retinal laser photocoagulation. The best-corrected visual acuity(BCVA), mean defect of visual field(MD), and central macular thickness(CMT)were examined before photocoagulation and 1mo, 3mo and 6mo after photocoagulation to compare the retinal function between the two groups.<p>RESULTS: The mean BCVA, MD and CMT values of the eyes in the PRP+ drug treatment group and the PRP treatment group were statistically significant(<i>P</i><0.05)at 1, 3, and 6mo after treatment. The mean BCVA, MD and CMT values between the two groups were statistically significant(<i>P</i><0.05)at 1 and 3mo after treatment. There was no significant difference at 6mo after treatment(<i>P</i>>0.05).<p>CONCLUSION: Qi Ming granule can alleviate the degree of laser photocoagulation damage to the retina, promote the rapid repair of laser damage, and reduce diabetic macular edema. It is worthy of popularization and application in the clinic.
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Based on the pharmacovigilance thoughts of Chinese medicine of cognition, application, prevention and rescue of drug toxicity, to sort out the pharmacovigilance information in representative herbal works of the Ming dynasty, and to analyze the characteristics of the pharmacovigilance thoughts of the Ming dynasty, so as to provide reference for rational drug use in modern clinical practice. Taking Bencao Pinhui Jingyao, Bencao Gangmu, Paozhi Dafa, Bencao Shengya Banjie, Bencao Mengquan as the blueprints, and taking the traditional Chinese medicines in these books as the research objects, the text information was extracted from the four aspects of drug identification, drug use, drug prevention and detoxification, and the idea of pharmacovigilance was summarized. In Ming dynasty, pharmacovigilance had a systematic understanding, and cognition of drug toxicity was clear in identifying poison and correcting the mistakes of predecessors, in the aspects of using and preventing poisons, the use of poisons was prominent, the compatibility and process of poisons were emphasized, and the methods and mechanism of poison relief were clear in detoxification. Ming dynasty has initially formed the whole pharmacovigilance theoretical frame of cognition, application, prevention and rescue of drug toxicity, which has certain guiding and reference significance for modern clinical rational drug use.
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Professor Shao Jing-ming had practiced Chinese medicine for more than 80 years with rich clinical experience and exquisite acupuncture techniques. From his clinical experience, Professor Shao's clinical features can be summarized as the followings: attaching importance to the theory of meridians and collaterals, combining pattern identification and disease identification, using fewer acupoints for treatment, and using Ashi point and Hegu (LI 4) to treat goiter. He emphasized the priority and sequence in acupoint-selection and manipulation. In treatment of epilepsy, he proposed to treat it according to the situation and paid great attention to the special function of the extraordinary acupoints. During the onset, it should be managed by calming the mind and controlling the symptoms; during the remission period, acupuncture and drugs should be applied simultaneously to regulate qi-blood and yin-yang, so as to reduce the frequency of attacks. He believed that acupuncture manipulation be one of the key factors in achieving the efficacy. In treatment of the motive diseases, such as convulsions and cramps, acupuncture with static and longer needle-retaining time should be adopted to control the limb movement, to strengthen the stimulation and to obtain a long-term efficacy. Professor Shao Jing-ming's medical records range from internal medicine, external medicine, gynecology and pediatrics, listing various refractory diseases effectively treated by him. Professor Shao was a moral and erudite Chinese medicine master, and his clinical experience is worthy of inheritance and development.
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Objective:To investigate the effect of electroacupuncture at Jiaji (EX-B2) points and Stomach Meridian Foot-Yang Ming points on the neurological function and the expression of local Synapsin I in rats after spinal cord injury, and to explore its molecular mechanism. Methods:A total of 60 Sprague-Dawley rats were established spinal cord injury model and they were randomly divided into normal control group, Jiaji group and Yang Ming group, with 20 rats in each group. On the third day after operation, Jiaji group and Yang Ming group were treated with electroacupuncture while the normal control group was not. Their neurological function was assessed with BBB every day. Four rats in each group were sacrificed at the end of the 1st, 2nd, 3rd, 4th and 5th week during the intervention period. HE staining was used to observe the morphology of spinal cord. Immumohistochemical staining was used to detect the expression of Synapsin I protein. Reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting was used to detect the content of of Synapsin I mRNA and protein. Results:The BBB scores were higher in Jiaji group and Yang Ming group than in the normal control group at all the time points (P < 0.05), and were higher in Yang Ming group than in Jiaji group from one to three weeks (P < 0.05). The immunohistochemical scores of Synapsin I protein were higher in Jiaji group than in the normal control group in the first week (P < 0.05), and were higher in Yang Ming group than in the normal control group from one to four weeks (P < 0.05). The immunohistochemical scores of Synapsin I protein were higher in Yang Ming group than in Jiaji group from three to four weeks (P < 0.05). The expression of Synapsin I mRNA and protein first increased and then decreased in the normal control group; which was higher in Jiaji group than in the normal control group in the first week (P < 0.05) and was higher in Yang Ming group than in the normal control group from one to four weeks (P < 0.05). The Synapsin I mRNA expression in the third week and the Synapsin I protein expression from two to three weeks was higher in Yang Ming group than in Jiaji group (P < 0.05). Conclusion:Electroacupuncture at both Jiaji points and Stomach Meridian Foot-Yang Ming points promote the recovery of nerve function in rats with spinal cord injury. It may be related to the elevated level of Synapsin I in the damaged parts of the spinal cord.
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Objective@#To investigate the effect of compound methoxyphenamine in the treatment of cough after infection.@*Methods@#From September 2016 to September 2017, 94 patients with infection after cough in the Traditional Chinese Medicine Hospital of Jinhua were selected in the research and randomly divided into two groups according to the digital table, with 47 cases in each group.The observation group was given compound methoxyphenamine, the control group was given azithromycin treatment.The treatment effect was compared between the two groups.@*Results@#Before treatment, the cough scores of the observation group and the control group were (1.4±0.7) points and (1.5±0.5)points, respectively.After treatment for one course, the cough scores of the observation group and the control group were (0.3±0.1)points and (0.8±0.2)points, respectively, the improvement of cough in the observation group was obviously better than that of the control group (t=5.024, P<0.05). After treatment, the total effective rates of the observation group and control group were 95.7%(45/47) and 83.0%(39/47), respectively, the treatment effect of the observation group was obviously better than that of the control group (χ2=11.265, P<0.05). After treatment, the incidence rates of adverse reaction of the observation group and the control group were 4.3%(2/47) and 21.3%(10/47), respectively, the incidence rate of adverse reaction of the observation group was lower than that of the control group (χ2=22.452, P<0.05).@*Conclusion@#The application of compound methoxyphenamine in patients with infection after cough can alleviate symptoms of patients with cough, reduce adverse reactions, has significant effect, so this kind of treatment method is worthy of popularizing in clinical use.
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Objective To investigate the effect of compound methoxyphenamine in the treatment of cough after infection.Methods From September 2016 to September 2017,94 patients with infection after cough in the Traditional Chinese Medicine Hospital of Jinhua were selected in the research and randomly divided into two groups according to the digital table,with 47 cases in each group.The observation group was given compound methoxyphena-mine,the control group was given azithromycin treatment.The treatment effect was compared between the two groups. Results Before treatment,the cough scores of the observation group and the control group were (1.4 ± 0.7) points and (1.5 ± 0.5)points,respectively.After treatment for one course,the cough scores of the observation group and the control group were (0.3 ± 0.1)points and (0.8 ± 0.2)points,respectively,the improvement of cough in the observa-tion group was obviously better than that of the control group (t=5.024,P<0.05).After treatment,the total effective rates of the observation group and control group were 95.7% (45/47) and 83.0% (39/47),respectively,the treat-ment effect of the observation group was obviously better than that of the control group (χ2 =11.265,P<0.05).After treatment,the incidence rates of adverse reaction of the observation group and the control group were 4.3% (2/47) and 21.3% (10/47),respectively,the incidence rate of adverse reaction of the observation group was lower than that of the control group (χ2 =22.452,P <0.05). Conclusion The application of compound methoxyphenamine in patients with infection after cough can alleviate symptoms of patients with cough,reduce adverse reactions,has signifi-cant effect,so this kind of treatment method is worthy of popularizing in clinical use.
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·AIM: To investigate the clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy (DR) with diabetic macular edema (DME). ·METHODS: The clinical data of 50 patients (98 eyes) with DME treated in our hospital from March 2014 to March 2017 were retrospectively analyzed. Patients were randomly divided into two group, 25 patients (48 eyes) treated with macular grid laser photocoagulation were included into the control group. On the basis of this, 25 patients (50 eyes) treated with Qi Ming granule were included into observation group. The central macular thickness(CMT) and best corrected visual acuity(BCVA) between two groups were evaluated and compared after detected by optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) at 7d, 1 and 3mo post-treatment. ·RESULTS: The total effective rate was 94% in the observation group with 47 effective eyes, which was was significantly higher than 83% in the control group with 40 effective eyes (P< 0. 05). The BCVA was significantly improved in the two groups after treatment; the BCVA of the observation group was significantly higher than that of the control group after 7d, 1 and 3mo treatment, the difference was statistically significant (P<0.05). CMT in the two groups after treatment decreased significantly;the CMT of the observation group was significantly lower than that of the control group after 7d, 1 and 3mo treatment, with statistical significance (P<0. 05). The intraocular hypertension occurred in observation group(2 eyes) and the control group (1 eyes), and relieved quickly after receiving medication, without any other obvious adverse reactions. ·CONCLUSION: The clinical efficacy of Qi Ming granule combined with macular grid laser photocoagulation in the treatment of diabetic retinopathy with macular edema is effective,which can reduce CMT,improve eyesight.
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Objective To compare the reprogramming effects and biological characteristics of two types of human odontogen-ic induced pluripotent stem cells(iPSCs).Methods Human dental pulp stem cells(DPSCs)and stem cells from apical papilla (SCAP)were isolated and primarily cultured.The Sendai reprogramming system was utilized to induce DPSCs and SCAP into iP-SCs.The morphology,reprogramming efficiency,reprogramming and time were compared between human DPSCs-iPSCs and SCAP-iPSCs.The SeV and exogenous transcriptional gene expression were detected by RT-PCR.Results Human DPSCs and SCAP were reprogrammed as iPSCs with classical ES-like clonal morphology.The reprogramming efficiencies were(0.68 ± 0.02)% and(0.7 ± 0.01)% respectively,the difference was not statistically significant(P>0.05).The reprogramming time was(26.0 ± 2.1)d and (27.0 ± 1.4)d respectively,the difference was not statistically significant(P>0.05).The RT-PCR results showed that no expres-sion of exogenous virus or transcriptional gene sequence in both iPSCs.Conclusion Human DPSCs and SCAP can be reprogrammed as virus-free and transgene-free iPSCs,which are the ideal sources of iPSCs.
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OBJECTIVE Vascular dementia (VD) refers to a progressive decline in memory and cognitive function caused by chronic cerebral ischemia. 2-Vessels occlusion (2-VO) has been widely used as a model of VD. Xiao-Xu-Ming decoction, a well-known traditional Chinese medicine prescrip-tion,has been widely used to treat stroke and sequelae of stroke.The present study was to investigate the mechanism of Xiao-Xu-Ming decoction(XXM) against chronic cerebral ischemia injury in rats. METHODS After XXM treatment, rats were performed a memory testing with Morris water maze and motor ability testing using prehensile test and inclined screen test.Neuronal plasticity was observed by immunofluorescent staining with MAP2 antibody. Differentially expressed proteins of rat hippocampus were analyzed by Label-free quantitative proteomics. RESULTS XXM significantly alleviated 2-VO-induced learning and memory deficits, motor ability dysfunction, and neuronal plasticity injury in rats. The mechanism might be involved in up-regulation of 39 proteins and down-regulation of 13 proteins in the hippocampus of rats after XXM treatment vs 2-VO group rats.Gene ontology and pathway analysis showed that the regulated proteins are mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process, etc. The signal pathways are mainly involved in ubiquitin mediated proteolysis and phosphatidylinositol signaling system. CONCLUSION Current findings provide new insights into the molecular mechanisms of XXM on chronic cerebral ischemia.
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OBJECTIVE Using bioinformatics methods, to establish Xiao-Xu-Ming decoction (XX-MD)"compound-vasoconstriction G Protein-Coupled Receptors(GPCR)targets"network,and analyze the vasoconstriction regulatory effective components and the potential targets of XXMD. METHODS Ac-cording to the XXMD herb sources,we retrieved the chemical structures from the national scientific da-ta sharing platform for population and health pharmaceutical information center,TCMSP database and the latest research literature.The chemical molecular library was established after class prediction and screening for medicinal and metabolic properties.Five kinds of vasoconstriction GPCR crystal structure including 5-HT receptors(5-HT1AR,5-HT1BR),AT1R,β2-AR,hUTR and ETB were retrieved from Bank Pro-tein Data Bank database or homology modeling using Discovery Studio 4.1 built-in modeling tools.After virtual screening by Libdock molecular docking,the highest rated 50 compounds of each target were col-lected and analyzed. The collected data were further used to construct and analyze the network. RE-SULTS 859 single compound structures information in XXMD were generalized following the screen-ing of obtained 2043 compounds.The complicated compound-vasoconstriction GPCR targets network of XXMD was then constructed and analyzed by molecular docking with the above five kinds of GPCR target receptors. Most of the chemical composition effects were associated with different vasoconstric-tion GPCR targets,while a few effective components can be applied to multiple GPCR targets at the same time,therefore forming synergies.CONCLUSION Vasorelaxant effects of XXMD may not only result from the collaborative interaction between a variety of active ingredients in Chinese medicine and multi-ple targets,but also from the interaction between some effective component and multiple targets.
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[Objective]To conclude and inherit Professor HE Yingchun's clincal academic experience and academic ideas. [Methods]By learing from professor HE Yingchun,recording the relevant cases and and analyzing cases,from the etiology and pathogenesis, therapeutic principle and therapy to generalize the treament of tinnitus. [Results]Professor HE Yingchun believes that the pathogenesis of tinnitus is " Turbid obstructs Qingqi"," Qingqi obstruction" and "Inner depression of Yangqi " ,she grabs the "Resolve cloudy, lift Qingyang and scattered fire evil" theory to treat tinnitus,regulating qi activity,clearing heat and promoting diuresis,invigorating qi and strengthening the spleen,replenishing qi, scattering fire evil,clearing biood stasis is the clinical common therapy, and she always obtains good effects in the treatment by using San Ren Decoction,Yi Qi Cong Ming Decoction and Sheng Yang San Huo Decoction. [Conclusion]Professor HE Yingchun always grabs the pathogenesis of tinnitus and adds other methods to treat the disase,and the curative effect is distinct ,her experience is effective and worthy of inheritance and promotion.
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@#AIM: To investigate the clinical effect of Qi Ming granule combined with calcium dobesilate in treatment of non-proliferative diabetic retinopathy(NPDR).<p>METHODS: Totally 94 patients with I～III stage NPDR in our hospital from January 2014 to May 2016 were collected and randomly divided into control group and observation group, all were unilateral, with 47 eyes in each group. The two groups were given control of blood glucose, diet and exercise therapy and other conventional treatment. The control group were treated with conventional western medicine calcium dobesilate treatment, 0.5g,3 times per day, the observation group combined with Qi Ming granule treatment based on control group treatment. Both groups were treated for 3mo. Two groups were observed before and after treatment for visual sensitivity and changes of serum cytokines \〖vascular endothelial growth factor(VEGF)and insulin-like growth factor-1(IGF-1), pigment epithelium derived factor(PEDG)\〗. Therapeutic effect and safety of the two groups were comprehensively evaluated and compared. <p>RESULTS: The average sensitivity of the observation group after treatment was lower than that before treatment and the control group after treatment, the difference were statistically significant(<i>P</i><0.05).The VEGF,IGF-1,PEDG of observation group after treatment, were significantly improved compared with the control group, the difference were statistically significant(<i>P</i><0.05). There were no obvious adverse reactions in the two groups, the total effective rate was 89% in the observation group, which was higher compared with the control group 72%, and the difference was statistically significant(<i>P</i><0.05). <p>CONCLUSION: Qi Ming granule combined with western medicine in the treatment of DR can effectively improve the function of the retina and ease the progress of the disease, and the safety is good, the clinical treatment effect is remarkable.
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AIM: To explore the effect of Bu Shen Yang Xue Ming Mu (BSYXMM) Formula on hydroquinone-induced oxidative stress injury in ARPE-19 cells.METHODS: The oxidative injury model of ARPE-19 cell was induced by exposure to various concentrations of hydroquinone (HQ) to determine the optimal concentration.Intestinal absorption solutions of BSYXMM Formula were prepared.Effect of intestinal absorption solutions of BSYXMM Formula on the cell viability was detected by CCK-8 assay,and the percentage of apoptotic cells was measured by TUNEL assay.The levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in ARPE-19 cells were detected by means of chemical colorimetry.RESULTS: It was found that ARPE-19 cell viability significantly decreased when the concentration of HQ was higher than 90μmol/L.Compared with the model group,1% and 2% intestinal absorption solutions in the pre-treatment group could significantly alleviate HQ-induced injury (P<0.01) and 0.5% and 5% intestinal absorption solutions in the pre-treatment group could alleviate the injury in certain degree(P<0.05).While in the treatment group 1% and 2% intestinal absorption solutions could alleviate the injury to some extent (P<0.05).TUNEL results showed that the apoptosis rate decreased significantly in the pre-treatment group (P<0.01)and to some extent in the treatment group (P<0.05)compared with the model group.It was shown that both levels of SOD and GSH-Px in pre-treatment group and treatment group were markedly higher than that of model group(P<0.05),and pre-treatment group had more significant effect (P<0.01,P<0.05).CONCLUSION: BSYXMM Formula could protect against HQ-induced oxidative stress injury in ARPE-19 cells,which may be related with the increasing of antioxidant enzyme in the cells.
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Objective To explore the clinical effect of Sophora powder combined with Xianfang-Huoming decoction for ulcerative colitis.Methods A total of 80 UC patients with TCM syndrome of excessive noxious heat were randomly divided into 2 groups (40 patients each group). The Western medicine group(control group) were treated with Mesalazin Enteric-coated tablets, and the Traditional Chinese medicine(observation group) group were treated with Sophora powder combined with Xianfang-Huoming decoction. The tumor necrosis factor-α(TNF-α)and Interleukin-8(IL-8) were detected. The Mayo index scores were conducted, and the curative effect and the recurrence rate were observed.ResultsAfter treatment, the level of TNF-α (66.11 ± 3.72 ng/Lvs. 92.61 ± 4.32 ng/L,t=29.398,P﹤0.01), IL-8 (53.11 ± 2.72 ng/L vs. 69.31 ± 1.32 ng/L,t=33.888,P﹤0.01)in the observation groupwere significantly lower than those in the control group. The Mayo index score (2.07 ± 0.57 vs. 3.30 ± 0.93, t=7.132,P﹤0.01) in the observation group was significantly lower than that in the control group. The total effective rate (92.5% vs. 85.0%,χ2=1.127, P=0.288) in the observation group was not significantly different from that in the control group. The recurrence rate (5.4% vs. 26.5%,χ2=6.005,P=0.013) in the observation group was significantly lower than that in the control group.Conclusions The Sophora powder combined withXianfang-Huoming decoction can treat the UC patients with TCM syndrome of excessive noxious hest, and the its recurrence rate is low.
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[Objective] Summary of Ming and Qing Dynasties and traditional Chinese medicine before tumor disease, to clarify the concept and to separate the tumor, and the tumor gall. [Method] Carefully read the documents of ancient Chinese medicine literature, combined with the relevant theoretical research methods of TCM, analyze the etiology and pathogenesis of neoplasia and its diagnosis and treatment system, summarize the theoretical system of the disease. [Results] The tumor is between blood stasis and phlegm stagnation. In time, the flesh skin membrane, between flesh and skin, because of its clinical and gall disease shows the organism body mass, so the ancient medical books of the two are collectively referred to as the gall disease. It is equivalent to the surface soft tissue tumor of modern medicine. [Conclusion] Before and after Ming and Qing Dynasties, Chinese medicine has formed a complete system of diagnosis and treatment of tumor, which has a good guiding effect on modern clinic.
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Objective To summarize the treatment principle of acupuncture-moxibustion in treating Bi-impediment syndrome from the application rules of meridians and acupoints in Ming-Qing Dynasties by sorting out and analyzing the Chinese medicine literatures about acupuncture-moxibustion for Bi-impediment syndrome in Ming-Qing Dynasties, for providing literature evidence for basic and clinical research of Bi-impediment syndrome.Method Via electronic retrieval ofZhong Hua Yi Dian (Zhen Jiu Tui Na Lei) (Chinese Medical Encyclopedia,Chapter of Acupuncture-Moxibustion and Tuina), the data related to Bi-impediment syndrome in Ming-Qing Dynasties were extracted to establish a database categorized by meridians and acupoint features in Excel for analysis.Result There were 267 items of records about acupuncture-moxibustion in treating Bi-impediment syndrome in Ming-Qing Dynasties, involving the fourteen ordinary meridians, and 131 acupoints including 5 extra points; the frequency of using the Gallbladder Meridian ranked the top, followed by the Large Intestine Meridian; points from the Bladder Meridian were predominant, followed by the Gallbladder Meridian; there were 28 commonly-used acupoints (frequency>5), which were Quchi (LI 11, 26 times), Huantiao (GB 30, 23 times), Hegu (LI 4, 22 times), Chize (LU 5, 16 times),Yanglingquan (GB 34, 15 times), and Weizhong (BL 40, 14 times). Of the specific acupoint, the five Shu points were most frequently used, with a frequency of 217.Conclusion In the treatment of Bi-impediment syndrome with acupuncture-moxibustion, doctors in Ming and Qing Dynasties selected yang meridians more often than yin meridians, and Gallbladder, Large Intestine and Bladder Meridians had comparatively higher frequencies; regarding the application of acupoints, the specific acupoints were often used, especially the five Shu acupoints. The study results provide reference for acupoint selection in the treatment of Bi-impediment syndrome with acupuncture-moxibustion.