A Comparison of Minimal Erythema Dose and Minimal Melanogenic Dose Induced by Ultraviolet A-1, Broad Band Ultraviolet A, Narrow Band Ultraviolet B, and Broad Band Ultraviolet B / 대한피부과학회지

BACKGROUND: The erythemal and tanning responses of the skin to UV radiations, which are used as diagnostic phototest and guideline of phototherapy, are different, depending on the races and light sources. Minimal erythema dose (MED), barely perceptible minimal melanogenic dose (MMDb) and well-defined border minimal melanogenic dose (minimal melanogenic dose, MMDw) of broad band UVA (BBUVA), UVA-1, broad band UVB (BBUVB), and narrow band UVB (NBUVB) have not yet been reported. Therefore this study was undertaken to measure the MED, MMDb and MMDw of BBUVA, UVA-1, BBUVB and NBUVB radiation. METHODS: Ten healthy Korean volunteers were recruited. Four volnuteers were Fizpatrick skin type III and six were IV. In this study, a metal halide lamp (SUPUVASUN 3000) was used as the BBUVA and UVA-1 light sources, a fluorescent blacklight lamp (Philips TL 20W/12 UVB lamp) as the BBUVB, and a fluorescent blacklight lamp (Philips TL 20W/01) as the NBUVB. The MED, MMDb and MMDw of the skin were visually assessed 24 hours and 7 days after irradiation. RESULTS: 1. BBUVA MED, MMDb and MMDw of BBUVA were 53.0+/-8.2J/cm2 (mean+/-S.D.), 38.0+/-7.8J/cm2, and 51.0+/-8.7J/cm2, respectively. MED, MMDb and MMDw of BBUVA in Fitzpatrick skin phototype III (FST III) were 50.0+/-8.1J/cm2, 35.0+/-5.7J/cm2, and 47.5+/-5.0J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 55.0+/-8.3J/cm2, 40.0+/-8.9J/cm2, and 53.3+/-10.3J/cm2, respectively. 2. UVA-1 MED, MMDb and MMDw of BBUVA were 58.0+/-9.1J/cm2, 40.0+/-4.7J/cm2, and 54.0+/-9.6J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 52.5+/-9.5J/cm2, 37.5+/-5.0J/cm2, and 52.5+/-12.5J/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 61.6+/-7.5J/cm2, 41.6+/-4.0J/cm2, and 55.0+/-8.3J/cm2, respectively. 3. BBUVB MED, MMDb and MMDw of BBUVA were 52.0+/-12.2mJ/cm2, 57.0+/-10.5mJ/cm2, and 69.0+/-11.0mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 42.5+/-5.0mJ/cm2, 55.0+/-5.7mJ/cm2, and 67.5+/-9.5mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 58.3+/-11.6mJ/cm2, 58.3+/-13.2mJ/cm2, and 70.0+/-12.6mJ/cm2, respectively. 4. NBUVB MED, MMDb and MMDw of BBUVA were 680+/-131.6mJ/cm2, 770+/-105.9mJ/cm2, and 910+/-99.4mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST III were 650+/-129.1mJ/cm2, 725+/-125.8mJ/cm2, and 850+/-100.0mJ/cm2, respectively. MED, MMDb and MMDw of BBUVA in FST IV were 700+/-141.4mJ/cm2, 800+/-89.4mJ/cm2, and 950+/-83.6mJ/cm2, respectively. CONCLUSION: The MMDb and MMDw induced by BBUVA and UVA-1 were less than MED induced by BBUVA and UVA-1, but MED induced by BBUVB and NBUVB was less than MMDb and MMDw induced by BBUVB and NBUVB. These results suggest that the erythemal and tanning response of the skin to UV radiations are different, depending on the UV wave length.

Relationship between UV-Induced Erythema and Pigmentation Dose-response Angles and The Predictors of Cutaneous Sensitivity to UV Light / 대한피부과학회지

BACKGROUND: There are many predictors of sensitivity to UVR, but controversies exist about their objectivity, correlation between them, and applicability to various races. OBJECTIVE: In 42 healthy volunteers, we assessed the validaty of dose response angle of erythe ma(DRAE) and delayed tanning(DRADT) after UVB irradiation, and also evaluated the correlation hetween dose-response angb s and other predictors of UV sensitivity. METHODS: We measured erythema and melanin index using reflectance spectrophotometer aft,er irradiation of UVB on the back of 42 males. When the erythema index and melanin index were plotted against UV doses for each patient, a dose response curve was obtained. Linear regression analysis was used to calculate the slope of those curves for erythema and delayed tanning, which were called DRAE and DRADl respectively. Also we checked predictots of UV sensitivity such as skin type, MED, MMD, consiitutional and facultative skin color, then analyzed the relation be tween dose response angles and other predictors. RESULTS: Statistically significa it linear regression lines were obtained from 41 subjects regarding to erythema and frorn 31 subjects regarding to delayed tanning. As for the relationship he tween the pvedictors of UV senitivity, only the MED correlated well with DRAE. CONCLUSION: We found that dose response angles, especially DRAE, were an objective and adequate predictor of cutaneous LJV sensitivity, but could not find validity of skin type and skin color in Koreans. A more organized study with a larger number of subjects is needed to clarify the usefulness of the predictors.

Study of the Minimal Erythema Dose and Minimal Melanogenic Dose of UVA - 1 and Minimal Phototoxic Dose of UVA - 1 and UVA - 2 in Young Adult Koreans / 대한피부과학회지

BACKGROUND: Minimal erythema dose(MED), minimal melanogenic dose (MMD) and minimal phototoxic dose(MPD) of UVA-1 in Koreans has not been determined, although MED and MMD of UVB and MPD of UVA-2 in Koreans have been reported. OBJECTIVE: This study was done to measure the MED and MMDs including minimal immediate tanning dose(MITD) and minimal delayed tanning dose(MDTD) of UVA-1 radiation and compare the MPD of UVA-1 with that of UVA-2. METHODS: In this study, a metal halide lamp (SUPUVASUN 3000) and a fluorescent blacklight lamp (Philips TL 20W/09N UVA lamp) were used as the UVA-1 and UVA-2 light sources, respectively. After the determining of Fitzpatrick's skin phototypes, the back skins of young adults were irradiated and the MED, MITD and MDTD of UVA-1 were assessed at 24 hours, 1 hour, and 7 days after irradiation, respectively. The minimal doses of phototoxic reaction, which was induced by oral 8-MOP plus UVA-1 or UVA-2, were assessed visually 72 hours after irradiation. RESULTS: MED,was 61.20+/-11.50J/cm(mean+S.D.). MITD and MDTD of UVA-1 were 48.00+/-8.57J/cm and 65.30+/-12.10J/cm respectively. MPDs of UVA-1 and UVA-2 were 14.88+/-3.88J/cm and 4.40+/-1.69J/cm, respectively. CONCLUSION: In this study, the MED and MMD of UVA-1 radiation and the MPD of UVA-1 and UVA-2 radiation were measured in young adult Koreans. The MITD was less than the MED, and the MDTD was almost the same as the MED. The MPD of UVA-1 was three times higher than that of UVA-2. There vere no significant correlations between the MEDs, MMDs or MPDs and the skin phototypes.

Study of the Minimal Erythema Dose and Minimal Melanogenic Dose of UVA - 1 and Minimal Phototoxic Dose of UVA - 1 and UVA - 2 in Young Adult Koreans / 대한피부과학회지

BACKGROUND: Minimal erythema dose(MED), minimal melanogenic dose (MMD) and minimal phototoxic dose(MPD) of UVA-1 in Koreans has not been determined, although MED and MMD of UVB and MPD of UVA-2 in Koreans have been reported. OBJECTIVE: This study was done to measure the MED and MMDs including minimal immediate tanning dose(MITD) and minimal delayed tanning dose(MDTD) of UVA-1 radiation and compare the MPD of UVA-1 with that of UVA-2. METHODS: In this study, a metal halide lamp (SUPUVASUN 3000) and a fluorescent blacklight lamp (Philips TL 20W/09N UVA lamp) were used as the UVA-1 and UVA-2 light sources, respectively. After the determining of Fitzpatrick's skin phototypes, the back skins of young adults were irradiated and the MED, MITD and MDTD of UVA-1 were assessed at 24 hours, 1 hour, and 7 days after irradiation, respectively. The minimal doses of phototoxic reaction, which was induced by oral 8-MOP plus UVA-1 or UVA-2, were assessed visually 72 hours after irradiation. RESULTS: MED,was 61.20+/-11.50J/cm(mean+S.D.). MITD and MDTD of UVA-1 were 48.00+/-8.57J/cm and 65.30+/-12.10J/cm respectively. MPDs of UVA-1 and UVA-2 were 14.88+/-3.88J/cm and 4.40+/-1.69J/cm, respectively. CONCLUSION: In this study, the MED and MMD of UVA-1 radiation and the MPD of UVA-1 and UVA-2 radiation were measured in young adult Koreans. The MITD was less than the MED, and the MDTD was almost the same as the MED. The MPD of UVA-1 was three times higher than that of UVA-2. There vere no significant correlations between the MEDs, MMDs or MPDs and the skin phototypes.

UVB Induced Minimal Erythema Dose ( MED ) and Minimal Melanogenic Dose ( MMD ) in Young Adult Koreans / 대한피부과학회지

BACKGROUND: The erythemal response and delayed tanning of the skin to UV radiations which are used as diagnostic phototest and guideline of phototherapy are different according to the races and light sources. OBJECTIVE: The MED and MMD induced by UVB radiation were measured in 130 normal young adult Koreans. METHODS: In this study, a high pressure mercury are lamp(Burdick UV-800) and a sunlight fluorescent lamp(Waldmann UV 800) were used as UVB light sources. Multiple sites of the lower baek or buttock skin were irradiated with an increasing dose by a constant, anount. The minimal doses of erythema response and delayed tanning of the skin were assessed visaually at 24 hours and 7 days after irradiation, respectively. RESULTS: MED and MMD of Burdick UV-800 are 18.0+/-9.8mJ/cm2 (mean+/-S.D.), 29.7+/-12.5mJ/cm2, respectively. MED and MMD of Waldmann UV 800 are 70.8+/-28.5mJ/cm2 and 91.2+/-33.1mJ/cm2, respecively. The most frequent MED by Burdick UV-800 is 10mJ/cm2 and those by Waldmann UV 800 are 50m J/cm2 and 60m J/cm2. CONCLUSION: In this study MED and MMD of young adult Koreans by two kinds of UVB light sources were assessed. The RESULTS: how that MED is less than MMD and the levels of MED under which the photosensitivity is suggested are 5.6mJ/cm2 by Burdick UV-800 anr 32.4mJ/cm2 by Waldmann UV 800.