A Case Report of MYH9 Gene Mutation Associated with Glomerular Minor Lesion / 罕见病研究

Non-muscle myosin heavy chain 9-related disease (MYH9-RD) is an autosomal dominant disease caused by the mutations of the MYH9 gene encoding the non-muscle mysoin heavy chain ⅡA and leads to abnormal accumulation of myosin in cells. These further causes functional disorders of the blood, eye, ear, kidney, and liver systems. MYH9-RD displays heterogeneous kidney involvement and outcomes, but doctors still lack understandings of the mechanism and treatment strategies, owing to difficulty of conducting renal biopsies. Here, we report a case of MYH9-RD with tail fragments heterozygous mutation, which renal pathology is presented as glomerular minor lesion. Moreover, we reviewed related relevant to strengthen clinical diagnosis and understanding of MYH9-RD.

Dissectional Orientation: Morphological Variations of Teres Minor Muscle and its Nerve Supply

SUMMARY: The teres minor is one of the rotator cuff muscles that comprise the superior margin of the quadrangular space. Quadrangular space syndrome (QSS) refers to the entrapment or compression of the axillary nerve and the posterior humeral circumflex artery in the quadrangular space, often caused by injuries, dislocation of the shoulder joint, etc. Patients who fail the primary conservative treatments and have persistent symptoms and no pain relief for at least six months would be considered for surgical interventions for QSS. This cadaveric study of 17 cadavers (males: 9 and females: 8) was conducted in the Gross Anatomy Laboratory at the Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University. The cadavers were preserved in a 10 % formaldehyde solution and obtained ethical approval by the ethical commission of the Siriraj Institutional Review Board. The morphology of the teres minor muscle-tendon junction, the bifurcation type of the axillary nerve, and the length and number of the terminal branches of the nerve to the teres minor were documented. Specimens with quadrangular space contents and surrounding muscles that had been destroyed were excluded from the study. The results showed that 47.06 % of the specimens had type A bifurcation, 47.06 % had type B bifurcation, and the remaining 5.88 % had type C bifurcation. It was observed that 58.82 % had nonclassic muscle-tendon morphology, while 41.18 % were classic. The average length of the terminal branches of the nerve to the teres minor in males was 1.13 cm, with the majority having two branches. For females, many showed one terminal branch with an average length of 0.97 cm. Understanding the differences in anatomical variations can allow for a personalized treatment plan prior to quadrangular space syndrome surgical procedures and improve the recovery of postsurgical interventions for patients.

El músculo redondo menor es uno de los músculos del manguito rotador que comprende el margen superior del espacio cuadrangular. El síndrome del espacio cuadrangular (QSS) se refiere al atrapamiento o compresión del nervio axilar y la arteria circunfleja humeral posterior en el espacio cuadrangular, a menudo causado por lesiones, dislocación de la articulación humeral, entre otros. En los pacientes en los que fracasan los tratamientos conservadores primarios y presentan síntomas persistentes y ningún alivio del dolor durante al menos seis meses se considerarían para intervenciones quirúrgicas para QSS. Este estudio cadavérico de 17 cadáveres (hombres: 9 y mujeres: 8) se llevó a cabo en el Laboratorio de Anatomía Macroscópica del Departamento de Anatomía de la Facultad de Medicina del Hospital Siriraj de la Universidad Mahidol. Los cadáveres se conservaron en una solución de formaldehído al 10 % y obtuvieron la aprobación ética de la comisión ética de la Junta de Revisión Institucional de Siriraj. Se documentó la morfología de la unión músculo-tendón del músculo redondo menor, el tipo de bifurcación del nervio axilar y la longitud y el número de las ramas terminales del nervio para el músculo redondo menor. Se excluyeron del estudio los especímenes con contenido de espacios cuadrangulares y músculos circundantes que habían sido destruidos. Los resultados mostraron que el 47,06 % de los especímenes presentó bifurcación tipo A, el 47,06 % una bifurcación tipo B y el 5,88 % restante una bifurcación tipo C. Se observó que el 58,82 % presentaba una morfología músculo-tendinosa no clásica, mientras que el 41,18 % era clásica. La longitud pmedia de los ramos terminales del nervio hasta el músculo redondo menor en los hombres era de 1,13 cm, y la mayoría tenía dos ramos. En el caso de las mujeres, mostraron un ramo terminal con una longitud promedio de 0,97 cm. Comprender las diferencias en las variaciones anatómicas puede permitir un plan de tratamiento personalizado antes de los procedimientos quirúrgicos del síndrome del espacio cuadrangular y mejorar la recupe- ración de las intervenciones posquirúrgicas de los pacientes.

Pleomorphic Adenoma of the Hard Palate: A Multidisciplinary Approach

Pleomorphic adenoma is the most common salivary gland tumor accounting for 80% of all major salivary gland tumors. It is a benign salivary gland neoplasm that constitutes 3% to 10% of the neoplasms in the head and neck region.1 Salivary gland neoplasms represents less than 1% of all tumors. This article is being showcased as a special case due to the fact it was done at a Taluk Hospital and also because ENT and oromaxillofacial surgeons were involved during the surgery.

In Vitro Comparative Study Of Four Electronic Apex Locators In Detecting Apical Constriction

Objective: Minor constriction which is the narrowest diameter is considered to be the appropriate apical limit of endodontic treatment. Apex locators provide greater precision, fewer procedural errors, less discomfort to the patient during measurement of working length. The aim of this article is to compare the accuracy of four electronic apex locators in detecting the apical constriction using histological sections as the gold standard. 80Materials and Methods: extracted single-rooted permanent teeth were selected and coronally flattened for stable reference point. Access cavity was prepared and canal patency was checked. Samples were embedded in alginate upto cemento-enamel junction. Working length was determined with the apex locators. A 15 K file adjusted to that reading was placed in the root canal and stabilized with flowable composite. Apical 4 mm of root was longitudinally sectioned and the position of the file in relation to the minor constriction was recorded for each tooth under stereomicroscope at 40X magnification. Chi-square test was carried out to test the difference in accuracy at various levels from the minor foramen. Kruskal Wallis Test was carried out to compare the differences between the study groups for the distance from the tip of the file relative to the minor foramen (P<0.05). Measurements of mean working lengths within ±0.5 mm of minor diameter were 85%Results: acceptable for CanalPro followed by Root ZX Mini (80%) and Propex Pixi (80%) and the least by DPEX V (65%). Conclusion: Accuracy of these instruments for detecting the minor diameter is acceptable for clinical practice

NECROTIZING SIALOMETAPLASIA OF PALATE A RARE CASE REPORT

Necrotizing sialometaplasia (NS) is a rare benign reactive necrotizing in?ammatory process that affects the minor salivary gland and frequently mimics cancer on both a clinical and histopathological level. Case Study : We report the case of a 21-year-old healthy man who had throat pain and non-healing ulcer over soft palate for the past one month, with pain during swallowing.Histopathological analysis and an incisional biopsy were performed on the patient. Necrotizing sialometaplasia was the histologically determined diagnosis. Necrotizing sialometaplasia is a self-limiting disorder of salivary glands mostly affecting the hard palate.The duration of the healing process is usually related to the size of the lesion.The recurrence rate of Necrotizing Sialometaplasia is low.Even a full thickness palatal lesion heals completely within 6 months.

Research progress on kidney transplantation rejection associated with non-HLA antibody / 器官移植

Human leukocyte antigen (HLA) is a product encoded by HLA gene complex, which is located on the short arm of chromosome 6 and is the main target of alloimmunity. However, positive HLA antibody is not responsible for all kinds of rejections in kidney transplantation. Non-HLA antibody is the product of donor gene expression in allogeneic kidney transplantation. Intraoperative ischemia-reperfusion injury, the interaction between alloimmunity and autoimmunity and the mediation of extracellular vesicles may trigger immune system response and promote the production of non-HLA antibody. Multiple studies have demonstrated that non-HLA antibody is an important factor of inducing rejection and affecting the outcomes of kidney transplantation. Consequently, the types and formation mechanism of non-HLA antibody in kidney transplantation were reviewed, and research progress on kidney transplantation rejection associated with non-HLA antibody was summarized, aiming to provide reference for in-depth study of kidney transplantation rejection associated with non-HLA antibody.

Endoplasmic reticulum aminopeptidase 1 and genetic susceptibility to pre-eclampsia / 中华围产医学杂志

Objective:To investigate whether endoplasmic reticulum aminopeptidase 1 ( ERAP1) is a susceptible gene for pre-eclampsia (PE) and the possible mechanism in the pathogenesis. Methods:This retrospective study included 990 PE patients (case group) and 1 240 healthy pregnant women (control group) in six prefecture-level tertiary hospitals in Shandong Province, including the Affiliated Hospital of Qingdao University and Zaozhuang Maternal and Child Health Hospital, from September 2018 to April 2021. Peripheral blood were collected for DNA extraction. Single-nucleotide polymorphisms in the ERAP1 gene (rs30187, rs27044, and rs469783 loci) were analyzed by Taqman probe polymerase chain reaction (PCR). Two missense mutant plasmids, rs30187(c.1583A>G) and rs27044(c.2188C>G), were constructed by point mutation induction based on wild-type plasmids. Six groups (knock-down control, knock-down, over-expression control, over-expression, variant 1 and 2 groups) were set up in this study. After transfecting Htr8 cells with different transfection molecules, the expression of ERAP1 at mRNA and protein levels were detected. Besides, the effects of different transfections on cell function were detected using Transwell migration assay, Transwell invasion assay, cell scratch assay, and CCK-8 assay. Statistical analysis was performed using two independent samples t-test, rank sum test, and Chi-square test. Results:(1) There were significant differences in the genetic distribution of rs30187 (Genotype: χ2=29.25, Allele: χ2=4.68) and rs469783 (Genotype: χ2=7.01, Allele: χ2=6.45) as well as the genotype distribution of rs27044 ( χ2=28.95) between the case group and the control group (all P<0.05). Statistical analysis of the genetic model revealed that rs30187 and rs27044, both recessive models, were statistically different between the two groups with a higher frequency of CC genotypes in the case group ( χ2=20.82 and 19.97, both P<0.05), but a lower frequency in CC dominant gene pattern for rs469783 ( χ2=5.82, P=0.016). (2) Compared with the knock-down control group, the knock-down group showed significantly inhibited expression of ERAP1 (mRNA: 0.5±0.1 vs 1.0±0.0, t=7.49; protein: 0.4±0.1 vs 0.7±0.1, t=2.81; both P<0.05), reduced cell migration rate after 48 h of scratching [(16.5%±1.8%) vs (23.8%±2.4%), t=3.33, P=0.031] and decreased number of cells crossing Transwell chambers after 24 h of culture (423.7±21.3 vs 499.0±24.6, t=3.29, P=0.031). Compared with the over-expression group, variant 1 group and variant 2 group showed significantly inhibited expression of ERAP1 at mRNA (both P<0.001) and protein ( P=0.003 and 0.006) levels after transfection, decreased number of cells crossing Transwell chambers ( P=0.001 and 0.032) and down-regulated cell migration rate after 48 h of scratching [variant 1: P=0.004; variant 2: (21.1±4.6)% vs (28.3±1.1)%, t=2.10, P=0.099]. ERAP1 expression at both mRNA ( P<0.001) and protein ( P=0.008) levels, as well as cell proliferation ( P<0.001) and invasion ability ( P<0.001), were all enhanced in the over-expression group than those in the over-expression control group. Moreover, the migration rate of cells after 48 h of scratching ( P=0.002) and the number of cells crossing Transwell chambers after 24 h of culture ( P=0.001) were also increased. Conclusions:The rs30187, rs27044, and rs46978 on ERAP1 gene were all associated with PE susceptibility, with more carriers of the CC genotype in PE patients at rs30187 and rs27044 loci and more carriers of the CC genotype in healthy gravida at rs469783 locus. ERAP1 may be involved in the pathogenesis of PE by affecting the migratory and invasive ability of trophoblast cells.

Prenatal diagnosis of fetal ZTTK syndrome: a case report / 中华围产医学杂志

This article reported the prenatal diagnosis of a fetus with ZTTK syndrome. A pregnant woman underwent preimplantation genetic diagnosis because her partner carried a balanced chromosomal translocation. Chromosomal karyotype analysis and copy number variation sequencing (CNV-seq) performed on amniocytes collected at 18 + weeks of gestation revealed no abnormalities. Ultrasonography performed at 23 +5 and 26 +3 weeks of gestation revealed severe fetal growth restriction, cerebellar dysplasia, poorly visualized sacrum and coccyx, and spina bifida. MRI of the fetal brain showed that the bilateral cerebellar hemispheres of the fetus were small and the cisterna magna was large at 23 +6 weeks of gestation. Whole exome sequencing in the pedigree identified a heterozygous variant c.2092delG (p.Glu698fs*4) in the exon 3 of the fetal SON gene, which was not inherited from the parents and proved to be a de novo mutation. Mutations in the locus are pathogenic, causing ZTTK syndrome. After genetic counseling, the pregnant woman and her family chose to terminate the pregnancy.

Biopsia hepática: experiencia en un hospital regional del sur de Chile / Liver biopsy: experience in a regional hospital in southern Chile

Introduction: Liver biopsy is an invasive procedure with a minimal rate of associated complications, which represents a highly useful strategy for the diagnosis of pathologies in the liver, when the etiology cannot be clarified by non-invasive techniques. It provides information that allows determining the progression and prognosis of liver diseases. Objectives: To evaluate the main etiology causes of liver disease in patients undergoing liver biopsy. Material and Methods: Review of the clinical record of 61 patients who underwent this procedure between 2018 and 2020 at the Hernán Henríquez Aravena hospital, demographic variables, diagnosis that motivates its performance, and associated complications. Results: Average age 58 years, of this 66% were female and 34% were male. The diagnoses that motivated this procedure were: autoimmune hepatitis, liver Tumors, and chronic liver damage of unknown etiology. 100% of the case had a satisfactory sample for the analysis and clarification of the cause of liver disease. 91% did not present complications and of the 8% associated with complications, pain was the most common. Conclusion: Liver biopsy is an effective method that allowed establishing etiology, confirming diagnosis suspicions, and evaluating the progression of liver disease with a low rate of complications.

Introducción: La biopsia hepática es un procedimiento invasivo con una tasa mínima de complicaciones asociadas, que representa una estrategia de gran utilidad para el diagnóstico de patologías a nivel del hígado, cuando a través de técnicas no invasivas no se logra esclarecer la etiología. Además, entrega información que permite determinar la progresión y pronóstico de enfermedades hepáticas. Objetivos: Evaluar las principales causas etiológicas de hepatopatías en los pacientes sometidos a biopsia hepática. Material y Método: Revisión de fichas clínicas de 61 pacientes sometidos a este procedimiento entre el año 2018 y 2020 en el hospital Hernán Henríquez Aravena, se analizaron variables demográficas, diagnóstico que motiva su realización, y complicaciones asociadas. Resultados: Edad promedio: 58 años de estos: 66% eran del sexo femenino y 34% al sexo masculino. De los diagnósticos que motivaron a la realización de la biopsia fuero: hepatitis autoinmune, tumores hepáticos y daño hepático crónico de etiología no precisada. El 100% de los casos tuvo una muestra satisfactoria para el análisis y esclarecer la causa de la hepatopatía. El 91% no presentó complicaciones y del 8% de las complicaciones presentadas, el dolor fue la principalmente descrita. Conclusiones: La biopsia hepática es un método eficaz que permitió establecer etiología, confirmar sospechas diagnósticas y evaluar progresión de enfermedades hepáticas con una baja tasa de complicación.

Acompanhamento farmacoterapêutico no contexto das doenças crônicas e distúrbios menores em uma unidade básica de saúde de São Luís-Ma / Pharmacotherapeutic follow-up in the context of chronic diseases and minor disorders in a basic health unit of São Luís-Ma / Seguimiento farmacoterapéutico en el contexto de enfermedades crónicas y trastornos más pequeños en una unidad de salud básica de São Luís-Ma

As doenças crônicas não transmissíveis (DCNT's) são responsáveis por cerca de 74% da mortalidade global. Nesse contexto, o acompanhamento farmacoterapêutico surge como uma importante ferramenta para garantir uma farmacoterapia racional em prol da melhoria da qualidade de vida do paciente. Levando isso em consideração, este estudo tem como objetivo avaliar o impacto do acompanhamento farmacêutico na qualidade de vida de um paciente idoso com tratamento irracional da hipertensão arterial sistêmica (HAS), diabetes mellitus e outros sintomas da síndrome metabólica. Paciente M.M.D., masculino, 67 anos, hiperglicêmico, dislipidêmico e que se automedicava para hipertensão sem diagnóstico médico com uma série de medicamentos potencialmente inapropriados (PIM's). Após as intervenções farmacêuticas apresentou melhora nos quadros e maior adesão à terapia medicamentosa atrelada a melhores hábitos de vida. Dessa forma, o impacto positivo das intervenções durante o acompanhamento farmacêutico reforça a importância do profissional na atenção básica e na promoção da saúde.

Chronic non-communicable diseases (NCDs) account for about 74% of global mortality. In this context, pharmacotherapeutic follow-up appears to be an important tool for ensuring rational pharmacotherapy in favor of improving the patient's quality of life. Taking this into consideration, this study aims to evaluate the impact of pharmaceutical follow-up on the quality of life of an elderly patient with irrational treatment of systemic arterial hypertension (SAH), diabetes mellitus and other symptoms of metabolic syndrome. M.M.D. patient, male, 67 years old, hyperglycemic, dyslipidemic and self-medicating for hypertension without medical diagnosis with a series of potentially inappropriate medications (PIM's). After the pharmaceutical interventions showed an improvement in the conditions and greater adherence to drug therapy coupled to better habits of life. Thus, the positive impact of interventions during pharmaceutical follow-up reinforces the importance of the professional in basic care and health promotion.

Las enfermedades no transmisibles crónicas representan aproximadamente el 74% de la mortalidad mundial. En este contexto, el seguimiento farmacoterapéutico es una herramienta importante para garantizar una farmacoterapia racional para mejorar la calidad de vida del paciente. Teniendo esto en cuenta, este estudio tiene por objeto evaluar el impacto del seguimiento farmacéutico en la calidad de vida de un paciente de edad avanzada con el tratamiento irracional de la hipertensión arterial sistémica (HAS), la diabetes mellitus y otros síntomas del síndrome metabólico. Paciente con M.M.D. masculino de 67 años de edad, hiperglucemia, dislipidemia y automedicación para la hipertensión sin diagnóstico médico con una serie de medicamentos potencialmente inapropiados (PIMs). Después de las intervenciones farmacéuticas, mostró una mejoría en las tablas y una mayor adherencia a la terapia con medicamentos, junto con mejores hábitos de vida. De esta manera, el impacto positivo de las intervenciones durante el seguimiento farmacéutico refuerza la importancia del profesional en la atención básica y la promoción de la salud.

Desrostificação e nomadopolítica em bla bla bla (1968), de Andrea Tonacci / Defacement and nomadopolitics in bla bla bla (1968), by Andrea Tonacci / Desfiguración y nomadopolítica en bla bla bla (1968), de Andrea Tonacci

Este texto é fruto de parte da pesquisa de doutorado em que buscamos defender, nas três primeiras produções do cineasta Andrea Tonacci, um nomadismo do pensamento, haja vista que, com suas imagens fílmicas, ele realiza um esforço de criação que foge ou faz fugir os mecanismos de poder e controle, optando pelo que vai além da opinião, dos clichês e da conservação, buscando doar um caráter revolucionário e minoritário à sua arte, possibilitando maquinar e construir junto a sua imagem novos sentidos, por meio da promoção do encontro capaz de fazer explodir as forças intensivas e ativas uma vez presentes nelas. Aportamo-nos no média-metragem Bla Bla Bla (1968), de forma a buscar perceber como, nesta película, Tonacci realiza movimentos inventivos de desrostificação, capazes de denunciar o esgotamento de um rosto político e abrir a sua imagem a novas possibilidades, realizando, com isso, uma nomadopolítica, atitude típica de um cinema-menor.

This text is the result of part of the doctoral research in which we seek to defend, in the first three productions of filmmaker Andrea Tonacci, a nomadism of thought, because with his filmic images, he makes an effort of creation that escapes the mechanisms of power and control, opting for what goes beyond opinion, clichés and conservation. Thus, he gives a revolutionary and minority character to his art, making it possible to machine and build new meanings together with his image. Based on his film Bla Bla Bla (1968), we will seek to understand how Tonacci carries out inventive movements of defacement, capable of denouncing the exhaustion of a political face and opening his image to new possibilities, thus realizing a nomadopolitics, a typical attitude of a minor cinema.

Este texto es el resultado de parte de la investigación doctoral en que buscamos defender, en las tres primeras producciones del cineasta Andrea Tonacci, un nomadismo de pensamiento, ya que con sus imágenes fílmicas realiza un esfuerzo de creación que huye o hace huir de los mecanismos de poder y control, optando por lo que va más allá de la opinión, de los clichés y de la conservación, buscando dar un carácter revolucionario y minoritario a su arte, posibilitando la construcción de nuevos significados junto a su imagen. A partir de su mediometraje Bla Bla Bla (1968), buscaremos comprender cómo, en este filme, Tonacci realiza movimientos inventivos de desfiguración, capaces de denunciar el agotamiento de un rostro político y abrir su imagen a nuevas posibilidades, realizando así, una nomadopolítica, actitud típica de un cine menor.

A variante menor em Deleuze: uma minoração da linguagem / The minor variant in Deleuze: a minoration of the language / La variante menor en Deleuze: una minoración del lenguaje

Partindo de dois pressupostos, 1) a linguagem é essencialmente política, não essencialmente comunicativa e informativa (Deleuze & Guattari, 1980), e 2), assim intervém na forma como as práticas sociais são organizadas, representadas, defendidas ou combatidas (Magalhães, Martinz, & Resende, 2017). O objetivo deste artigo é apresentar a variante menor como uma ferramenta conceitual e política das minorias na contemporaneidade. Para isso, descrevemos relações entre os conceitos "maioria", "minoria" e "devir-minoritário" (Deleuze, 1979), para o estudo do funcionamento da variante menor. A partir desses conceitos, fomentamos uma discussão sobre línguas maiores e menores no Brasil (Deleuze, 2010) e, em seguida, deslocamos essa discussão para a literatura, a partir do conceito "literatura menor" (Deleuze & Guattari, 1975). Por fim, apresentamos o problema da linguagem como palavra de ordem (Deleuze & Guattari, 1980). Concluímos a discussão propondo a variante menor como uma ferramenta de minoração da linguagem que intervém na produção, circulação e recepção de imagens e textos em diferentes práticas sociais.

Starting from two assumptions, 1) language is essentially political, not essentially communicative, and informative (Deleuze & Guattari, 1980), and 2) language intervenes in the way social practices are organized, represented, defended, or fought (Magalhães, Martinz, & Resende, 2017). The aim of this article is to present the minor variant as a conceptual and political tool for minorities in contemporary times. For this, we describe relationships between the concepts of "majority", "minority" and "becoming-minority" (Deleuze, 1979), for the study of the functioning of the minor variant. Based on these concepts, we fostered a discussion about major and minor languages in Brazil (Deleuze, 2010), and then moved this discussion to literature, based on the concept of "minor literature" (Deleuze & Guattari, 1975). Finally, we present the problem of language as a watchword (Deleuze & Guattari, 1980). We conclude the discussion by proposing the minor variant as a language mitigation tool that intervenes in the production, circulation and reception of images and texts in different social practices.

Partiendo de dos supuestos, 1) el lenguaje es en esencia político, no esencialmente comunicativo e informativo (Deleuze & Guattari, 1980), y 2) el lenguaje interviene en la forma en que se organizan, representan, defienden o combaten las prácticas sociales (Magalhães, Martinz, & Resende, 2017), el objetivo de este artículo es presentar la variante menor como herramienta conceptual y política de las minorías en la contemporaneidad. Para ello, describimos relaciones entre los conceptos "mayoría", "minoría" y "devenir-minoría" (Deleuze, 1979), para el estudio del funcionamiento de la variante menor. Con base en estos conceptos, fomentamos una discusión sobre lenguas mayores y menores en Brasil (Deleuze, 2010), y luego trasladamos esta discusión a la literatura, con base en el concepto de "literatura menor" (Deleuze & Guattari, 1975). Finalmente, presentamos el problema del lenguaje como consigna (Deleuze & Guattari, 1980). Concluimos la discusión proponiendo la variante menor como una herramienta de mitigación del lenguaje que interviene en la producción, circulación y recepción de imágenes y textos en diferentes prácticas sociales.

Criações e devires em filosofias e teatros menores: intercessões teatrais com Gilles Deleuze & Felix Guattari / Creations and becomings in minor philosophies and theaters: theatrical intercessions with Gilles Deleuze & Felix Guattari / Creaciones y devenimientos en filosofías y teatros menores: intercesiones teatrales con Gilles Deleuze y Felix Guattari

Este artigo trabalha as criações e os devires em filosofias e teatros menores, através da explicitação de tais procedimentos pela filosofia de Deleuze e Guattari. Assim, ao definirmos as noções de maioria, minoria, criações e devires-minoritários nos dois filósofos, mostraremos tais procedimentos como minoritários e criaremos a oportunidade de lermos tais processos ocorrerem no Teatro de Carmelo Bene, para investigamos no final um possível cotejamento entre estes pensamentos. Ao confirmarmos no final o teatro filosófico minoritário de Deleuze e Guattari, criaremos a ressonância indispensável que dará destaque e originalidade política e ética ao empreendimento construtivo dos dois autores.

This article works on the creations and becomings in minor philosophies and the theaters, through the explanation of such procedures by philosophy of Deleuze and Guattari. This way, when we define the notions of majority, minority, creations, and minor changes in both philosophers, we will show such procedures as minority and we will create the opportunity to read such procedures in the Theater de Carmelo Bene, to investigate, at the end, a possible comparison between such thoughts. When we conclude in a positive way the minority philosophical theater of Deleuze and Guattari, we will create an indispensable resonance that will give emphasis and political originality and ethics to the constructive enterprise of both authors.

Este artículo trabaja sobre creaciones y devenires en filosofías y teatros menores, a través de la explicitación de tales procedimientos por parte de la filosofía de Deleuze y Guattari. Así, cuando definimos las nociones de mayoría, minoría, creaciones y devenires minoritarios en los dos filósofos, mostraremos dichos procedimientos como minoritarios y crearemos la oportunidad de leer como tales procesos ocurren en el teatro de Carmelo Bene, para investigarmos al final una posible comparación entre estos dos pensamientos. Confirmando al final el teatro filosófico minoritario de Deleuze y Guattari, crearemos la resonancia indispensable que dará protagonismo y originalidad política y ética a la empresa constructiva de los dos autores.

A rare case of neonatal intestinal obstruction

Omphalocele minor is often associated with the presence of other anomalies compared to that of omphalocele major. The occurrence of intestinal atresia is seldom associated with omphalocele minor. Prompt diagnosis and intervention can prevent morbidity and mortality. Following is a rare case report of combination of omphalocele minor and intestinal atresia with strangulation of the proximal bowel.

Case report on adenoid cystic carcinoma of palate with review of literature

Adenoid cystic carcinoma (ACC) is a malignant tumor of minor salivary glands of the oral cavity, particularly the palate which accounts for about 5–10%. These tumors are slow growing with a high incidence of local recurrence, perineural invasion, and distant metastasis. Here, we report the case of a 69-year-old female who presented with swelling over the hard palate. Computerized tomography shows enhancing lesion along the undersurface of the left side of the hard palate, abutting the maxillary alveolus in the region of the second premolar and first two molars. There was no erosion of the inner cortex of the maxillary alveolus and no extension into the nasal cavity. Following the biopsy, she underwent a left hard palatectomy with upper alveolar resection. The final histopathological report confirmed ACC with no perineural invasion. Following she received adjuvant radiotherapy using an intensity-modulated radiotherapy technique. Now at 6 months of follow-up, there was no evidence of recurrence. Thus, our patient requires long-term follow-up to assess the benefit and survival outcome.

Estudio piloto de los factores que intervienen en el cumplimiento del calendario de vacunación en las madres con niños menores de 5 años / Pilot study of the factors involved in compliance with the vaccination schedule in mothers with children under 5 years of age

Diferentes características socio demográficas describen una disminución en el proceso de vacunación en niños originando rebrotes de enfermedades que se suponían controladas. Objetivos, comprobar la confiabilidad del instrumento de investigación para medir los factores que intervienen en el cumplimiento del calendario de vacunación en las madres con niños menores de 5 años. Materiales y métodos: esta investigación se empleo la metodología mixta, de corte transversal, exploratoria, descriptiva, en la cualitativa se usó la técnica fenomenológica con instrumentos diseñados por los investigadores y validado por juicio de expertos, Resultados. El instrumento de recolección de datos es validado con un puntaje promedio de pertinencia 89, validez de 90 y coherencia 89. Equivalente a 89.33 de confiabilidad, alfa de Cronbach de 0,07, Conclusiones. El instrumento al ser confiable está en condiciones de ser utilizado en investigaciones subsiguientes, teniendo en cuenta que la población a la que se aplicó reúne condiciones específicas de una área rural, dentro de los factores que modifican el cumplimiento del proceso de vacunación se recalcó las creencias de las madres del sector, quienes manifiestan un estado de inseguridad e incertidumbre al oponerse a la aplicación de vacunas a sus hijos, se detalla el estado emocional con tendencia a la depresión con rasgos de ansiedad de las madres como resultado de la actitud de su cultura de desconfianza(AU)

Different sociodemographic characteristics describe a decrease in the vaccination process in children, causing outbreaks of diseases that were supposed to be controlled. Objectives, to verify the reliability of the research instrument to measure the factors that intervene in the fulfillment of the vaccination schedule in mothers with children under 5 years of age. Materials and methods: this research used the mixed, cross-sectional, exploratory, descriptive methodology, in the qualitative one the phenomenological technique was used with instruments designed by the researchers and validated by expert judgment, Results. The data collection instrument is validated with an average relevance score of 89, validity of 90 and coherence of 89. Equivalent to 89.33 reliability, Cronbach's alpha of 0.07, Conclusions. The instrument, being reliable, is able to be used in subsequent investigations, taking into account that the population to which it was applied meets specific conditions of a rural area, within the factors that modify compliance with the vaccination process, beliefs of the mothers of the sector, who manifest a state of insecurity and uncertainty when opposing the application of vaccines to their children, the emotional state with a tendency to depression with anxiety traits of the mothers as a result of the attitude of their culture is detailed. of mistrust(AU)

Hiperplasia Adenomatoide en Reborde Alveolar Maxilar: Una Presentación Inusual

RESUMEN: La hiperplasia adenomatoide (HA) se considera una patología no neoplásica de etiología desconocida asociada principalmente a trauma como principal factor causal, con localización frecuente en paladar duro y blando. El presente caso muestra el primer caso de HA en reborde alveolar asociado a prótesis removible mal adaptada. Hombre de 81 años con diabetes mellitus y HTA controlada presentaba un aumento de volumen nodular en reborde alveolar maxilar del color de la mucosa, de consistencia firme y márgenes definidos que medía 1,5 x 0,7 cm de diámetro, asintomático y asociada a falta de diente 1.3 protésico reportando 6 años de evolución. Se realizó biopsia excisional y estudio histopatológic o con hiperplasia de acinos glandulares. El 80 % de los casos se observa en paladar seguida de la mucosa oral, lengua y zona retromolar, pero sin reportes en encía o reborde alveolar. El factor causal mayormente asociado es el trauma crónico principalmente asociado a prótesis mal adaptadas, aunque existen estudios de un cromosoma aberrante con un rol desconocido tanto en su patogénesis como en su posible potencial maligno. En el caso actual, la lesión se asocia fuertemente a prótesis removible mal adaptada sugiriendo una lesión de aspecto reactivo. Por lo tanto, la HA se debe incluir como diagnóstico diferencial tanto a nivel palatino como en otras localizaciones incluyendo reborde alveolar. Además, se debe considerar cuando existe un factor etiológico traumático como prótesis removibles mal adaptadas, siendo necesario su confirmación mediante estudio histopatológico especialmente por su similitud con otras patologías.

ABSTRACT: Adenomatoid hyperplasia (AH) is considered a non-neoplastic pathology of unknown etiology but mainly associated with trauma as the main causal factor, with frequent localization on hard and soft palate. The present case shows the first case of AH on the alveolar ridge associated with a poorly adapted removable prosthesis. An 81-year-old man with diabetes mellitus and arterial hypertension controlled presents a nodular tumor in the maxillary alveolar ridge of the color of the mucosa, with a firm consistency and defined edges measuring 1.5 x 0.7 cm in diameter, asymptomatic and associated with a lack of a 1.3 prosthetic tooth reporting 6 years of evolution. Excisional biopsy and histopathological study were performed with glandular acini hyperplasia. The AH is observed in 80 % of cases on the palate followed by the oral mucosa, tongue and retromolar area, but without reports on the gingiva or alveolar ridge. The most associated causal factor is chronic trauma, mainly associated with poorly adapted prostheses, although there are studies of an aberrant chromosome with an unknown role both in his pathogenesis and possible malignant potential. In the current case, the lesion is strongly associated with a poorly adapted removable prosthesis, suggesting a lesion with a reactive appearance. Therefore, AH should be included as a differential diagnosis both at the palatal level and in other locations including the alveolar ridge. In addition, it should be considered when there is a traumatic etiological factor such as poorly adapted removable prostheses, It's confirmation by histopathological study being necessary, especially due to its similarity with other pathologies.

Public’s Preferences for Community Pharmacy Attributes and Their Perceptions Towards Pharmacist-led Minor Ailment Services in Malaysia

@#Introduction: The prospect of public accessing community pharmacies for minor ailment advice or treatment highly depends on the pharmacy attributes and their staff. This study aimed to investigate the extent to which community pharmacies are used as a source of minor illness management and the public’s relative preferences for pharmacy features. Methods: A cross-sectional survey among the public in Malaysia was carried out between August and December 2020. The validated self-administered questionnaires were distributed at several pharmacies and shared via email, Whatsapp group, and Facebook. Results: A total of 141 from 153 public respondents completed the survey. From the descriptive and inferential analysis, it was found that about a third of the public goes to a pharmacy for advice or treatment for minor illnesses. The vast majority of respondents had positive perceptions that community pharmacists are knowledgeable and qualified to offer advice or treatment for minor diseases. A significant positive relationship was observed between pharmacy characteristics’ scores and pharmacy staff and pharmacy services’ scores (p<0.001). The increase in pharmacy staff score significantly increased the pharmacy services’ score (p<0.001). Conclusion: The implications of the public acknowledging specific attributes were crucial in further supporting community pharmacists’ services, especially in the private practice setting.

The demographics of minor perpetrators of sexually assaulted pediatric patients from the Philippine General Hospital - Child Protection Unit (PGH-CPU) from January 2013 to December 2018

Background@#Child sexual assault has been underreported, more so, those who minor perpetrators have assaulted. Surveillance for these children, victims and perpetrators alike, must be established. @*Objective@#The objective was to describe the characteristic profile of the minor perpetrators who committed child sexual abuse seen in Philippine General Hospital - Child Protection Unit (PGH-CPU) from January 2013 to December 2018. @*Methodology@#This retrospective cohort study was conducted using chart review and data retrieval from the Child Protection Management Information System (CPMIS) of the PGH-CPU.@*Results@#There were 931 minor perpetrators. 55.9% were 15-19 years old and were predominantly male. 12.7% came from Cavite and 9.5% from Manila. Most were neighbors, acquaintances, and cousins of the victims. 39.4% were still students. 14.4% engaged in alcohol consumption. 7.7% have repeatedly abused children. 6.1% already had police blotter records. 7.3% were exposed to pornography. 7.5% are currently in jail, and 4.1% are in the same household as the victim. @*Conclusion@#A child’s environment is potentially contributory to their actions. The minor perpetrators reported were observed to have adverse childhood experiences like violence in their families. Although sexual abuse cases focus on the victims, it is equally vital that authorities give attention to minor perpetrators because they are also children. Programs and interventions should be provided for them to grow up to be better individuals in society.

Suppurative minor salivary gland sialolithiasis

ABSTRACT Sialolithiasis is a common nonneoplastic disease of the major salivary glands that often affects the submandibular glands. Minor salivary gland involvement by sialolithiasis is uncommon, with only 273 cases reported. A long clinical history, acute symptoms, and mucopurulent discharge are unusual features of these cases. Herein, we report the case of a 63-year-old woman who complained of symptomatic nodular swelling of the buccal mucosa associated with purulent discharge for several days. The clinical history lasted 15 years, with episodes of asymptomatic non-suppurative swelling in the same area. The patient underwent surgical excision. The microscopic examination revealed chronic nonspecific sialadenitis associated with psammomatous calcifications, confirming minor salivary gland sialolithiasis. After 3 years of follow-up, the patient was free of symptoms. Patients with sialolithiasis are usually asymptomatic; however, swelling, pain, and fistula may be present in rare cases. The presence of purulent exudate should lead to the differential diagnosis of stomatitis glandularis, a rare inflammatory condition affecting the minor salivary glands. Sialolithiasis and stomatitis glandularis should be considered in the clinical differential diagnosis of symptomatic suppurative nodular swelling affecting the oral mucosa, and histopathological analysis is necessary for the diagnosis.