ABSTRACT
Objective To observe the clinical efficacy of modified Huanglian Wendan Decoction for treatment of tic disorder (TD) children with syndrome of wind stirring due to phlegm-heat; To detect its effects on peripheral-blood miR-429 expression. Methods Eighty cases of TD children were randomly divided into treatment group and control group,with 40 cases in each group.In the treatment group,children were treated with modified Huanglian Wendan Decoction, one dosage a day, twice a day, orally. In the control group, TD children were treated with haloperidol, 0.03 mg/(kg?d), orally, according to the symptom to adjust dose, and the maximum amount did not exceed 0.08 mg/(kg?d). 30 d was a treatment course for both groups. The treatment lasted for three courses. Before and after 3 months of clinical observation, the severity of disease was evaluated by TCM syndrome and Yale Global Tic Severity Scale (YGTSS) score. Clinical efficacy and TCM syndrome efficacy were evaluated; the level of miR-429 in peripheral blood was detected; the adverse reactions were observed. Results The total effective rate of clinical efficacy was 82.5% (33/40) in treatment group and 80.0% (32/40) in the control group, without statistical significance (P>0.05); The total effective rate of TCM syndrome efficacy was 92.5% (37/40) in treatment group and 75.0% (30/40) in the control group, with statistical significance (P<0.05). Compared with before treatment, the YGTSS score and TCM syndrome score significantly decreased after treatment (P<0.01), and the TCM syndrome score in the treatment group was much lower than the control group after treatment (P<0.05). Compared with before treatment, miR-429 level in both groups increased obviously after treatment (P<0.01), and the miR-429 level in the treatment group was much higher than the control group after treatment (P<0.05). There were mild constipation (1 cases), diarrhea (2 cases), and anorexia (2 cases) in the treatment group, and obvious lethargy (3 cases) and dizziness (3 cases) in the control group. Conclusion Modified Huanglian Wendan Decoction shows obvious effects for treating TD, and can up-regulate miR-429 of peripheral-blood.
ABSTRACT
[Objective]Observe the clinical curative effect of phlegm-fire syndrome insomnia treated by Modified Huanglian Wendan Decoction.[Method] Col ect 208 cases phlegm-fire syndrome insomnia patients in the clinic which were randomly divided into two groups. 112 cases in the treating group were treated by Modified Huanglian Wendan Decoction, and 96 patients in the control group were given lmg estazolam.30d as a course, and observe the clinical curative effect after the course, including total effective rate, PSQI,TCM syndrome score and side-effect, etc. [Results]The total effective rate of phlegm-fire syndrome insomnia patients treated by Modified Huanglian Wendan Decoction was 91.96%, and the control group was 77.08%, there was significant difference between two groups. There were significant differences between two groups in PSQI ,TCM syndrome score and adverse reaction, too, it suggests that the treatment group is better than the control group.[Conclusion]The Modified Huanglian Wendan Decoction has a definite curative effect on phlegm-fire syndrome insomnia, and with little adverse reaction.