ABSTRACT
In order to adapt to the rapid development of experimental techniques in the field of cell molecular biology, to quickly and effectively cultivate the experimental skills of postgraduates, systematic reforms should be carried out on advanced cellular molecular biology skill experiment teaching. The combi-nation of basic theory, biological experiment and practical application enables students to master the basic techniques from drawing materials to molecular biology analysis and construct in vitro transgenic cell model. Adding clinical case analysis, simulated ethical review and other lively classroom activities, which can help students carry out scientific research as soon as possible, improve students' interest and cultivate students' teamwork ability. The teaching effect is good and worth promoting.
ABSTRACT
El Óxido Nítrico (NO) es un radical libre gaseoso que juega roles prominentes en señalamiento celular, expresión y regulación génica, energética celular, proliferación celular y citostasis, e inmunidad celular y tolerancia, incluyendo funciones inflamatorias. Aunque NO sirve a roles beneficiosos como citotrófico, vasodilatador, antiangiogénico, anti-trombótico, anti-inflamatorio, defensa inmune del huésped, antiproliferativo y antioxidante, su excesiva producción puede ser citotóxica, vasoconstrictora, pro-angiogénica, protrombótica, pro-inflamatoria, proproliferativa y oxidante, a causa de la endógena producción de intermediarios reactivos del nitrógeno y/o el oxígeno. Esta revisión explora el conocimiento colectivo del rol de las NO-Sintetasas (NOSs) en biología, patobiología, bioclínica humana y nuevas oportunidades en prevención y tratamiento...
The Nitric Oxide (NO) is a gaseosus free radical that plays prominent roles in cell signaling, gene expression and regulation, cellular energetics, cell proliferation and cytostasis, and cell immunity and tolerence including inflammatory functions. Althoug NO serves benificial rolesas cytotrophic, vasodilator, anti-angiogenic, antithrombotic, anti-inflammatory, host defense, antiproliferativeand antioxidant, excessive production can be cytotoxic, vasoconstrictor, pro-angiogenic, prothrombotic, proinflammatory, pro-proliferative and oxidant, because endogenous production of reactive nitrogen and/o oxygen intermediates. The review explores the collective knowledge of the role of NO-Synthetases (NOSs) in human biology, pathobiology, bioclinic and new opportunities in prevention and treatment.