ABSTRACT
Mongolian blue spots are birthmarks that are present at birth and their most common location issacrococcygeal or lumbar area. There are macular and round, oval or irregular in shape. Lesionsmay be single or multiple. They usually spontaneously regress and disappear during childhood.The prevalence of Mongolian blue spots varies among different ethnic groups according to theoverall depth of pigmentation. Mongolian blue spots are common among Asian, East Indian, andAfrican races, but rare among Caucasian and other races. Mongolian blue spot is a congenital,developmental condition exclusively involving the skin. Mongolian blue spot results from entrapmentof melanocytes in the dermis during their migration from the neural crest into the epidermis. Thismigration is regulated by exogenous peptide growth factors that work by the activation of tyrosinekinase receptors. It is postulated that accumulated metabolites such as GM1and heparin sulfatebind to this tyrosine kinase receptor and lead to severe neurologic manifestations and aberrantneural crest migration.
ABSTRACT
BACKGROUND:Mongolian spots (MS) are congenital birthmarks seen most commonly over the lumbosacralarea. They are bluish-green to black in color and oval to irregular in shape. Dermal pigmentationappears gray, greyish-blue or greyish black because these colors have a shorter wavelength andare reflected to the skin surface. The amount of melanin in the dermal melanocytes, the numberof dermal melanocytes and their depth in the dermis are also important determinants of color. TheMongolian blue spots often fade in a few years and are almost always gone by adolescence.AIM:The aim of this study was to determine the frequency and characteristics of Mongolian spots in 1-10-years-old children.MATERIALS AND METHODS:The study was carried out on 1000 children who were lived in Ulaanbaatar during 2013-2014.Children were carefully examined for the presence of Mongolian spots, including the hairy skin,during the systematic physical examination. If a spot was observed, localization, size, color andshape were recorded. Statistical analysis was done using SPSS-21.RESULT:96.8% (95%CI 95.7-97.8) of the children’s was residents of Ulaanbaatar city, 49.2% [95%CI 46.1-52.5] of boys. The color of the Mongolian spots varied from pale blue to grayish blue. The mostfrequently involved sites were the lumbosacral areas. There was a disappearance in the incidenceof Mongolian spots with advancing age.CONCLUSION:The study shows that prevalence of blue spot among children aged 1-10 years old decreased withage and blue spot tended to disappear after the age of 10.
ABSTRACT
The blue spot distribution in the world and its health effects were published in previous review article. The current article presents the historical overview of blue spot in some Mongolian historical literature sources.For the literature review, we have used ancient Mongolian literature sources such as “Mongoliin Nuuts Tovchoo”, “Altan tovch”, “Erdeniin tovch”, “Shar tuuj”, “Khokh Mongoliig turuur badraakh hutagtai neruit zasag” “Asragch nertiin tuukh”, “Altan deed unenii ayalguu” and other historical, anthropological literature sources and studies.For centuries, Mongolians have symbolized blue as the color of “Eternal Blue Sky”. It is a symbol of long-lasting life, and everything for a Mongolian. In ancient Mongolian historical books, color blue and its symbolism have been recorded.According to some ancient historical literature sources, Mongolians were born with blue spot more than 40000 years ago.As articulated in historical and genetics literature sources, “Mongolian Blue spot” may have been distributed among Native American, Asian and African infants.
ABSTRACT
Scientists and doctors publishing papers on prevalence, genetic and medical significance of Mongolian blue spots since 1700 years.The Mongolian spot is a congenital developmental condition exclusively involving the skin. The blue color is caused by melanocytes, melanin-containing cells that are deep under the skin.As demonstrated in literatures n, native and Caucasians, Polynesians Prevalence of Mongol spots among the newborns in various ranges 1-100 per cent in various countries. Literatures published in last year's dem¬onstrating about some metabolic diseases and cancers observed among the children with Mongol spot. It is need to conduct more depth studies among population with dark skin.