ABSTRACT
Objective: To study the chemical constituents in Qili Qiangxin Capsule (QQC) and to clear its material basis for efficacy. Methods: A rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) method was established to identify the diterpenoid alkaloids in the active fraction of QQC. Using target compound screening method, the structures of monitored chemical constituents were identified by retention time, exact relative molecular mass, and cleavage fragments of MS/MS. Results: Twenty diterpenoid alkaloids were identified using XIC Manager, including 6 diester-diterpenoid alkaloids and 14 monoester-diterpenoid alkaloids. Conclusion: This method is simple and rapid for the identification of the constituents in QQC and the results are useful for the quality control of QQC.