Patrones morfológicos de la enfermedad glomerular en México: Reporte de un centro de referencia en nefropatología / Morphological patterns of glomerular disease in Mexico: Report of a reference center in nephropathology

RESUMEN Introducción: En México, la enfermedad renal crónica (ERC) representa un gran problema de salud y las glomerulopatías (GP) representan la tercera causa de ERC. Objetivo: Describir, desde una base de datos de biopsias renales (BR) nativas, los diferentes patrones morfológicos de GP en México. Métodos: Se analizaron registros de BR de riñón nativo en un centro de referencia en nefropatología, todas las BR fueron evaluadas por una única nefropatóloga (AVP). El diagnóstico final en cada caso se basó en parámetros clínicos e histopatológicos. Resultados: Fueron revisadas 2084 BR, con edad de 34.4 ± 17.6 años. 1085 BR (52.1%) en género femenino; el síndrome nefrótico fue más frecuente en hombres (p<0.001) y síndrome nefrítico fue más frecuente en mujeres (p<0.001). GP primarias y nefropatías túbulo-intersticiales fueron más diagnosticadas en hombres (p<0.01). Nefritis lúpica (NL) fue la GP secundaria más reportada. La glomeruloesclerosis focal y segmentaria (GEFS) fue la GP primaria diagnosticada con mayor frecuencia en ambos géneros. Vasculitis por inmunoglobulina A fue la enfermedad vascular más frecuentemente detectada. Síndrome nefrótico fue la indicación más frecuente de BR (42.9%), seguido de: síndrome nefrítico (23.9%), proteinuria aislada (16.4%), daño renal agudo (8.7%), alteraciones urinarias asintomáticas (6.2%) y ERC (1.8%). Conclusiones: La GP primarias con mayor frecuencia fueron GEFS. Las GP secundarias más frecuentemente reportadas fueron NL, predominantemente en mujeres. Se observó nefropatía IgA con mayor frecuencia en comparación con otras series publicadas en México. Hubo diferencias significativas en la presentación de GP en relación con el género y la edad del paciente.

ABSTRACT Introduction: In Mexico, chronic kidney disease (CKD) represents a major health problem, and glomerulopathies (GP) represent the third leading cause of CKD. Aim: From a database of native kidney biopsies (KB), describe the different morphological patterns of GP in Mexico. Methods: Records of native KB in a nephropathology referral center were evaluated by a single nephropathologist. The final diagnosis in each case was based on clinical parameters and histopathological findings. Results: 2084 KB were analyzed, patients were 34.4±17.6 years of age, there were 1085 KB (52.1%) in females; nephrotic syndrome was most frequent in males (p<0.001), and nephritic syndrome was more frequent in females (p <0.001). Primary GP and túbulo-interstitial diseases were most diagnosed in males (p <0.01). Lupus nephritis (LN) was the most-reported secondary GP. Focal and segmental glomerulosclerosis (FSGS) was the primary GP most often diagnosed in both genders. The most frequently detected vascular disease was immunoglobulin A vasculitis. Nephrotic syndrome was the most frequent indication for KB (42.9%), followed by: nephritic syndrome (23.9%), isolated proteinuria (16.4%), acute kidney injury (8.7%), asymptomatic urinary alterations (6.2%), and CKD (1.8%). Conclusions: The most frequently observed primary GP was FSGS, and LN was the most frequent secondary GP, predominantly in females, and IgA nephropathy was observed more frequently in comparison with other series published in Mexico. There were significant differences in GP presentation in relation to patient sex and age.

Morphological Patterns of Traumatic Head Injury in Medicolegal Autopsies at Muhimbili National Hospital, Dar ESSalaam Tanzania

Introduction: Head injury is predicted to surpass many diseases as a major cause of death and disability by the year 2020. There is a limited documentations on morphological patterns of traumatic Head Injury and its prevalence specifically in Medical legal Autopsy in Tanzania population. The aim of this study was to determine the morphological patterns of Traumatic Head Injury (TBI) in Medical legal autopsies seen at Muhimbili National Hospital (MNH). Subjects and Methods : This was a hospital based cross -sectional study conducted at MNH mortuary. The postmortem examination was performed under Virchow method on 170 cases of TBI in which morphological patterns of TBI was recorded. Proportional of TBI frequencies on various morphological patterns in medical legal autopsies were recorded. Association between cause of death and etiology of TBI were established by Fisher - exact test.Results:The proportion of TBI among the medico - legal autopsy at MNH was 38.5%. All cases of TBI had scalp abrasion, and the majority had linear fra cture 67(39.3%) and the commonest the parietal bone was commonly affected 85(55.6%). In closed TBI, majority had subarachnoid hemorrhage130 (84.9%). All cases of T BI had brain edema, with one coincidental finding of metastatic adenocarcinoma. A total of 42 cases of TBI had brain herniation, 51 brain laceration and 52, had brain contusion. The association between etiology of injury, wearing helmets among motor cycle user and cause of death was statistically significance (p<0.05). Conclusion:The higher pro portion of TBI among medicolegal autopsies at MNH reflects the burden of head injury in our settings.

Clinicopathological study of anemia during pregnancy

Background: In developing countries the prevalence of anemia among pregnant women averages 60% resulting in varying levels of adverse pregnancy outcomes. Iron, Vitamin B12 and folic acid deficiencies, malaria, intestinal parasitic infections and hemoglobinopathies are the principal causes of anemia in pregnancy. Above nutritional requirements increase during pregnancy and if it is not maintained, may result in adverse maternal and fetal outcomes. The aim of this study was to study the prevalence of anemia in pregnant mothers, study the clinical patterns of anemia in pregnancy and to study the histopathological patterns of anemia during pregnancy.Methods: This is a prospective study done on 60 pregnant women whose hemoglobin level is less than 10.9 gm/dL. Blood samples were taken, and peripheral blood smears were examined along with their complete clinical and obstetric history.Results: Out of 60 cases of anemia, 40% were found to have dimorphic anemia, 30% with microscopic hypochromic anemia, 20% of patients have normocytic hypochromic anemia, 1.7% had sickle-cell anemia and 8.3% of patients were thalassemia cases. The risk factors for anemia in this study is noted to be low social economic status, occurrence of complications during previous pregnancy and multiparty. In this study anemia was more commonly found in the multigravida women and in the third trimester of pregnancy.Conclusions: With improved social economic conditions, early detection, good antenatal care, awareness regarding available treatment, a healthy diet, routine antenatal counselling and adequate iron supplementation, anemia in pregnancy can be avoided.

Morphological patterns of gingival recession in adult chilean population / Patrones morfológicos de recesiones gingivales en población chilena adulta

The aim of this study was to determine the prevalence of morphological patterns of gingival recession, attachment loss, and type of interdental papilla in adult subjects of different age in a Chilean population. A total of 105 patients with ages ranging from 18 to 64 years of both sexes participated in our study. The prevalence of gingival recession was 92.38 percent, affecting 530 teeth. The morphological pattern of gingival recession most common was class II (34.94 percent), followed by types III, I and IV. According to ANOVA test, differences were significant in relation to the mean number of affected teeth. Of those who had recessions, females had a slightly higher prevalence. The range 18-34 years showed a prevalence of 82.22 percent and from 35 years increased to 100 percent. The vertical extent between 0-3mm and horizontal between 4-7mm were the most prevalent affected 88.68 percent and 59.05 percent of teeth, respectively. Attachment loss was 3-4mm in 316 teeth (59.62 percent), and the most prevalent interdental papillae on the different patterns was type I (40.18 percent) followed by type III (21.88 percent). Differences were statistically significant (p=0.001) in relation to age of individuals who presented diferent morphological patterns of gingival recession. For the others parameters (depth and width of the recession, attachment loss) we found no statistically significant differences with a confidence interval of 95 percent. These findings represent a contribution for the evaluation of gingival recession in our population, particularly in the anterior aesthetic zone.

El objetivo fue determinar los patrones morfológicos de recesión gingival más prevalentes junto al grado de pérdida de inserción clínica y tipo de papila interdentaria en una muestra de población chilena. Se evaluaron 105 pacientes de ambos sexos, con edades entre 18 y 64 años. La prevalencia de recesión gingival fue del 92,38 por ciento, afectando 530 dientes. El patrón morfológico de recesión más frecuente fue el clase II (34,94 por ciento), seguido por los tipos III, I y IV. Según la Prueba de ANOVA, fueron encontradas diferencias significativas en relación a las medias de dientes afectados entre los individuos que presentaban recesión. El sexo femenino presentó una prevalencia ligeramente mayor. En el rango de 18-34 años se observó una prevalencia de 82,22 por ciento y desde los 35 años aumentó al 100 por ciento. La extensión vertical entre 0-3mm y horizontal entre 4-7mm fueron las más prevalentes y afectaron al 88,68 por ciento y 59,05 por ciento de los dientes, respectivamente. La perdida de inserción más habitual fue del rango 3-4mm en 316 dientes (59,62 por ciento ). El tipo de papila interdentaria en las recesiones gingivales fue del tipo I (40.18 por ciento) seguido por el tipo III (21.88 por ciento). Se encontraron diferencias estadísticamente significativas (p=0.001) en relación a la edad de los individuos que presentaron estos patrones morfológicos de recesión gingival y quiénes no. Estos resultados representan una contribución para la evaluación de la recesión gingival en nuestra población, particularmente en la zona estética anterior.

Discovering craniofacial patterns using multivariate cephalometric data for treatment decision making in orthodontics / Descubriendo patrones craneofaciales usando datos cefalométricos multivariados para la toma de decisiones en ortodoncia

The aim was to find craniofacial morphology patterns in a multivariate cephalometric database using a clustering technique. Cephalometric analysis was performed in a sample of 100 teleradiographs collected from Chilean orthodontic patients. Thirty cephalometric measurements were taken from commonly used analysis. The computed variables were used to perform a clustering analysis with the k-means algorithm to identify patterns of craniofacial morphology. The J48 decision tree was used to analyze each cluster, and the ANOVA test to determine the statistical differences between the clusters. Four clusters were found that had significant differences (P<0.001) in 24 of the 30 variables studied, suggesting that they represent different patterns of craniofacial form. Using the decision tree, 8 of the 30 variables appeared to be relevant for describing the clusters. The clustering analysis is effective in identifying different craniofacial patterns based on a multivariate database. The distinct clusters appear to be caused by differences in the compensation process of the facial structure responding to a genetically determined cranial and mandible form. The proposed method can be applied to several databases, creating specific classifications for each one of them.

El objetivo fue encontrar patrones morfológicos craneofaciales, a partir de una base de datos cefalométricos multivariada, utilizando una técnica de clustering. Se realizó un análisis cefalométrico a una muestra de 100 telerradiografías pertenecientes a pacientes chilenos de ortodoncia. Treinta medidas cefalométricas obtenidas de los análisis más utilizados fueron registradas. Las variables computadas se utilizaron para realizar un análisis de clustering con el algoritmo k-medias, para identificar patrones de morfología craneofacial. El árbol de decisión J48 se utilizó para analizar cada cluster, y test de ANOVA para determinar diferencias estadísticamente significativas entre los clusters. Se encontraron cuatro clusters con diferencia estadísticamente significativas (p<0,001) en 24 de las 30 variables estudiadas, lo que sugiere que efectivamente corresponden a diferentes patrones craneofaciales. Utilizando el árbol de decisión, se pudo determinar que 8 de las 30 variables resultaron ser relevantes en la definición de los clusters. El análisis de clustering es efectivo en identificar patrones morfológicos craneofaciales usando una base de datos multivariada. Los distintos cluster encontrados, aparentemente se formarían a partir de diferencias en el proceso de compensación de la estructura facial, en respuesta a la forma mandibular genéticamente determinada. El método propuesto puede ser aplicado a múltiples bases de datos, creando clasificaciones específicas para cada una de ellas.

Morphological patterns of self-etching primers and self-etching adhesive bonded to tooth structure / 대한치과보존학회지

The purpose of this study was to compare in vitro interfacial relationship of restorations bonded with three self-etching primer adhesives and one self-etching adhesive. Class I cavity preparations were prepared on twenty extracted human molars. Prepared teeth were divided into four groups and restored with four adhesives and composites: Clearfil SE Bond/Clearfil(TM) AP-X (SE), UniFil Bond/UniFil(R) F (UF), FL Bond/Filtek(TM) Z 250 (FL) and Prompt L-Pop/Filtek(TM) Z 250 (LP) After storing in distilled water of room temperature for 24 hours, the specimens were vertically sectioned and decalcified. Morphological patterns between the enamel/dentin and adhesives were observed under SEM. The results of this study were as follows; 1. They showed close adaptation between enamel and SE, UF and FL except for LP. 2. The hybrid layer in dentin was 2 microm thick in SE, 1.5 microm thick in UF, and 0.4 microm in both FL and LP. So, the hybrid layers of SE and UF were slightly thicker than that of FL and LP. 3. The lengths and diameters of resin tags in UF and FL were similar, but those of LP were slightly shorter and slenderer than those of SE. 4. The resin tags were long rod shape in SE, and funnel shape in other groups. Within the limitations of this study, it was concluded that self-etching primer adhesives showed close adaptation on enamel. In addition, the thickness of hybrid layer ranged from 0.4-1.5 microm between adhesives and dentin. The resin tags were long rod or funnel shape, and dimension of them was similar or different among adhesives.