ABSTRACT
Quality control of ahomeopathic mother tincture begins with the analysis of the raw material. Once the product is obtained, some organoleptic characteristics and Physicochemical properties such as appearance, colour, odour, density, dry residue, alcohol content,and chemicalmarker are evaluated. In Brazil, mother tinctures from different suppliers may have high variability in terms of the specifications described in the homeopathic pharmacopoeia. Objective: The aim of the present study was to compare mother tinctures' quality control from different pharmaceutical suppliers based on Brazilian Homeopathic Pharmacopoeia 3rd edition. Methods: Five mother tinctures were selected according to the high number of requests in the pharmacies, also its monographs are in the Brazilian Homeopathic Pharmacopoeia (FHB) 3rd edition. The report of analysis of the product was provided by three homeopathic pharmacies from the city of Rio de Janeiro. The information in the reports wasevaluated and compared to its monograph. Results and discussion: In this study, it was found that the number of laboratories that provide homeopathic pharmaceutical ingredients is rather low. In addition, in some reports, a number of identification tests werenot described properly when compared to the monograph. Besides that, some information diverges from the pharmacopoeia, for example, absence of dry residue testing, replacement of the part of the plant used to prepare the mother tincture,and results that do not meet pharmacopoeia specifications. As can be seen, the quality and effectiveness of homeopathic medicines prepared from these tinctures may be compromised. Conclusion:In order to guarantee consumer protection and the quality and effectiveness of medicines, governments and regulatory agencies should requirea greater commitment from suppliers in the production of homeopathic inputs.
Subject(s)
Quality Control , Mother TinctureABSTRACT
Boswellia Serrata Mother Tincture knownas Indian Frankincenses (gugle),is an herbal extract taken from the Boswellia Serrata tree.it is use in treatment of chronic Inflammatory changes as well as a number of other illness. Studies show that boswellia may reduce inflammation. Because boswellia is an effective anti-inflammatory, it can be an effective painkiller and may prevent the loss of cartilage. Here is an attempt made to determine the efficacy of Homeopathic Mother Tincture to bring about desired result in Rheumatoid Arthritis cases.
ABSTRACT
Objective: To evaluate the in vitro antifungal activity of extracts, resins, oils and mother tinctures from plants against the filamentous fungi Fusarium guttiforme (F. guttiforme) and Chalara paradoxa, and to evaluate the control of the pineapple fusariosis in situ using mother tinctures. Methods: The screening of the antifungal potential of 131 extract forms from 63 plant species was performed in vitro by using plate-hole method. To control pineapple fusariosis in situ, preventive and post-infection treatments were performed on detached pineapple leaves of cv. Pérola (susceptible). Results: The quantitative study indicated that among the 49 mother tincture samples analyzed, 46% were effective against F. guttiforme and 29% for the Chalara paradoxa. The natural plant extracts, mother tincture of Glycyrrhiza glabra (MTGG1), mother tincture of Myroxylon balsamum (MTBT2), mother tincture of Aloe vera (MTAV3), mother tincture of Allium sativum (MTAS4), resin of Protium heptaphyllum (RESAM5) and crude extracts of Rhizophora mangle (CEMV6), exhibited an antifungal activity against F. guttiforme. In the preventive treatment against pineapple fusariosis, MTAV3, MTAS4 and MTGG1 were statistically similar to the treatment with tebuconazol fungicide. The curative treatments with MTAV3, MTAS4, MTGG1 and MTBT2 presented similar activity to fungicide (P < 0.05). Conclusions: The findings of the present study concluded that mother tinctures can effectively control phytopathogens. The mother tincture extract of Myroxylon balsamum showed antifungal activity and was used here for the first time for inhibition of phytopathogenic fungi. This study paves the way for the development of bioactive natural products with phytosanitary applications, with the added benefits of an environmentally safe and economically viable product.
ABSTRACT
Objective: To evaluate the in vitro antifungal activity of extracts, resins, oils and mother tinctures from plants against the filamentous fungi Fusarium guttiforme (F. guttiforme) and Chalara paradoxa, and to evaluate the control of the pineapple fusariosis in situ using mother tinctures. Methods: The screening of the antifungal potential of 131 extract forms from 63 plant species was performed in vitro by using plate-hole method. To control pineapple fusar-iosis in situ, preventive and post-infection treatments were performed on detached pineapple leaves of cv. P′erola (susceptible). Results: The quantitative study indicated that among the 49 mother tincture samples analyzed, 46% were effective against F. guttiforme and 29% for the Chalara paradoxa. The natural plant extracts, mother tincture of Glycyrrhiza glabra (MTGG1), mother tincture of Myroxylon balsamum (MTBT2), mother tincture of Aloe vera (MTAV3), mother tincture of Allium sativum (MTAS4), resin of Protium heptaphyllum (RESAM5) and crude extracts of Rhizophora mangle (CEMV6), exhibited an antifungal activity against F. guttiforme. In the preventive treatment against pineapple fusariosis, MTAV3, MTAS4 and MTGG1 were statistically similar to the treatment with tebuconazol fungicide. The curative treatments with MTAV3, MTAS4, MTGG1 and MTBT2 presented similar activity to fungicide (P Conclusions: The findings of the present study concluded that mother tinctures can effectively control phytopathogens. The mother tincture extract of Myroxylon balsamum showed antifungal activity and was used here for the first time for inhibition of phyto-pathogenic fungi. This study paves the way for the development of bioactive natural products with phytosanitary applications, with the added benefits of an environmentally safe and economically viable product.
ABSTRACT
There is a dearth of chemico-analytical or instrumental methods for standardization and quality control of higher dilutions of homeopathic drugs. Aim: This review highlights the challenges in standardization of anti-inflammatory homeopathic drugs and suggests a battery of biological assays for their standardization. Methods: We retrieved a total 57 scientific reports from the experimental studies and scientific reviews published between January 1999 and June 2014 related to anti-inflammatory homeopathic drugs and their high dilutions. These comprised of 18 reports on preclinical evaluation, 15 on source materials, 9 on isolated constituents and 15 studies on in-vitro experiments. Few recent citations which supported the initial studies were added later during the compilation of the manuscript. Conclusion: Standardization and quality control of homeopathic mother tinctures and high dilutions warrants an urgent attention. As biological activities are observed to be attributed to the high dilutions which are practically devoid of active ingredients, their standardization may be done through the suggested battery of biological investigations. It is suggested that the current methods of standardization of homeopathic drugs need to be upgraded to include sensitive, reproducible and relevant biological assays so that the end users are assured of the quality, efficacy, and safety of homeopathic dilutions...
Subject(s)
Humans , High Potencies , Anti-Inflammatory Agents/chemistry , Biological Assay , Homeopathy , Mother Tincture , In Vitro Techniques , Homeopathic Remedy , Quality of Homeopathic RemediesABSTRACT
Sampled population was children under 6 years with acute respiratory infection and the sample were obtained from sputum. The aim was to determine the changes in the concentrations ob both, lisozyme and total protein, before and after the intervention with the garlic mother tincture. It was a pilot study quantitative and through a system of nonrandomness simple of the probabilistic a sample of 25 individuals for determining if you belong to the treatment group (mother tincture) or control (placebo). The results indicate a decrease in the concentration of lysozyme and total proteins in the treatment group between 3 to 5 days after initiated treatment, on the other hand the control group showed an increase in the measurements. Only the treatment group showed positive changes in type symptomatical of the disease. Mother Tincture of garlic is a phytotherapeutic alternative excellent for effectively combat acute respiratory infections in children.
La población muestreada fueron niños menores de 6 años con I.R.A y la muestra fue obtenida de la expectoración. El objetivo fue determinar los cambios en la concentraciones de lisozima y proteínas totales, antes y después de la intervención con la tintura madre de ajo. Fue un estudio cuantitativo experimental y a través de un sistema de aleatoriedad simple del tipo probabilístico se toma una muestra de 25 individuos para determinar si pertenecerán al grupo tratamiento (tintura madre) o control (placebo). Los resultados obtenidos indican una disminución en la concentración de lisozima y proteínas totales del grupo tratamiento entre los 3 a 5 días después de iniciado el tratamiento, en cambio el grupo control reveló un aumento en las mediciones. Solamente el grupo tratamiento evidenció cambios positivos de tipo sintomatológico de la enfermedad. La tintura madre de ajo es una excelente alternativa fitoterapeútica para el combate eficaz contra las infecciones respiratorias agudas en niños.