ABSTRACT
OBJECTIVE: To study the relationship between surface roughness and mucoadhesion properties of oral film. METHODS: Polydimethylsiloxane reverse templates were fabricated from sandpapers with different roughness, and were used as the mold to prepare films by solvent casting method. The obtained films were then evaluated for mucoadhesive force, shear force, mucoadhesion time, and their morphology was investigated by scanning electron microscopy (SEM). RESULTS: Films of c-hitosan showed more favorable mucoadhesive performance than those of Bletilla striata gum. Generally, the prepared films exhibited different mucoadhesion properties, among which #400 films showed the best performance. CONCLUSION: The mucoadhesion properties of films were significantly affected by their surface roughness, which are wo-rthy of further study.