Application research of multi-dimensional interaction combined with PBL teaching in emergency and critical care nursing practice teaching / 中华医学教育探索杂志

Objective:To explore the value of multi-dimensional interaction combined with problem-based learning (PBL) teaching in the nursing practice teaching of emergency and critical care.Methods:A total of 110 nursing students who practiced in the First Affiliated Hospital of Xinjiang Medical University from June 2019 to March 2020 were selected as the control group, and the traditional teaching was adopted. In addition, 89 nursing students who practiced from June 2020 to December 2020 were selected as the research group, and multi-dimensional interaction combined with PBL teaching was adopted. The teaching quality was assessed through the comprehensive scores of the nursing students (departure examination + regular performance assessment) and nursing students' feedback on the teaching. SPSS 22.0 was used for t-test and Chi-square test. Results:The comprehensive scores of the nursing students in the research group were higher than those in the control group, and the difference was statistically significant ( P<0.001). Compared with the control group, the nursing students in the research group believed that multi-dimensional interaction combined with PBL teaching could improve nursing knowledge and skills, overall clinical nursing ability, self-management ability, clinical thinking ability, and the ability to analyze, judge and solve clinical nursing problems, group cooperation ability, communication ability between doctors, nurses and patients, emergency ability and rescue ability, and professional quality, with statistically significant differences ( P<0.001). Conclusion:Multi-dimensional interaction combined with PBL teaching can improve the theoretical and clinical practice level of nursing interns, and at the same time help to cultivate nursing talents with excellent comprehensive quality.

Study on influencing factors and needs of medical personnel in scientific research of a tertiary hospital in Jieyang / 中华医学科研管理杂志

Objective:To understand the needs, problems and challenges of medical personnel in the hospital for scientific research, propose tailored management measurements and suggestions for the hospital.Methods:The questionnaire was prepared by " Questionnaire Star" , the convenience sampling method was used, and information was collected by WeChat online chat group. Factor analysis and multi-dimensional preference analysis were adopted to analyze information collected.Results:Four main factors that affect the scientific research of medical personnel were identified. The most significant impact is the lack of information platform, followed by the lack of environmental atmosphere, lack of personal capacity and lack of personal interest. The research needs of medical personnel are divided into two categories: one is the more basic skill needs, which are mainly targeted at female, nurses, undergraduates, 5~10 years′ working experiences, medium-grade professional title, and people with no knowledge and experience in research. The other one is the needs of skill improvement, which are mainly targeted at younger, physicians, early career, lower professional titles, and had certain research knowledge.Conclusions:So far, there is a lot of space for improvement. It is recommended to promote the capacity building by training, strengthen the research team building and construct of research communication platform, at the same time, update the scientific research management system.

The reliability and validity of multi-dimensional, quantitative video evaluation of the hand function of stroke survivors / 中华物理医学与康复杂志

Objective:To test the reliability and validity of a multi-dimensional, quantitative video evaluation system (the Multi-dimensional system) for evaluating hand dysfunction among stroke survivors so as to provide an objective basis for its clinical application.Methods:Sixty stroke survivors with single dysfunctional hand were evaluated using the Multi-dimensional system and also using the Fugl-Meyer Upper Extremity Assessment (FMA-UE) and the Action Research Arm Test (ARAT) and in terms of their active range of hand motion (AROM-H). The Multi-dimensional system′s internal consistency, composite reliability, split-half reliability, parallel-forms reliability as well as intra- and inter-observer reliability were quantified. Its validity was tested in terms of content validity, structural validity, convergent validity and criterion validity.Results:The system′s Cronbach′s α was determined to be 0.86. Its one-dimension composite reliability was 0.939, its split-half reliability coefficient was 0.88 and its parallel-forms reliability was 0.922. The inter-evaluator reliability was between 0.965 and 0.998 [95%CI= (0.919, 0.999)], and the single evaluator ICC value was 0.973 to 0.998 [95%CI= (0.937, 0.999)]. The validity test produced a content validity index of 1, and the Pearson correlation coefficients between each sub-item and the total score were all greater than 0.60. The KMO value for structural validity was 0.882, and there was a common factor in the component matrix which reflected 60.9% of the information in the original variables. The system′s convergent validity AVE was 0.609 with Pearson correlation coefficients between the multidimensional system and the FMA-UE and ARAT both > 0.70.Conclusion:The multi-dimensional quantitative video evaluation system has good reliability and validity in the evaluation of stroke survivors with hand dysfunction.

Clinical evaluation on idiopathic pulmonary fibrosis / 中南大学学报(医学版)

Idiopathic pulmonary fibrosis (IPF) is a chronic fatal pulmonary disease characterized by complex illness condition. There is no effective treatment at present except lung transplantation. The comprehensive evaluation is helpful for the management of patients with IPF in hierarchical stages. Therefore, it is very important to evaluate IPF by various independent factors. At present, the commonly used methods for clinical evaluation on IPF include assessment of health-related quality of life, assessment of physiological function, assessment of imaging, assessment of laboratory examination, and multi-dimensional assessment system. However, there are different advantages and disadvantages on diverse evaluation methods for the evaluation of IPF.

Construction of multi-dimensional teaching reform system of Biochemistry based on outcome-based education / 生物工程学报

Biochemistry is an important fundamental course of biology related majors, and has the characteristics of speedy development, massive information, sound theoretical basis and feasible applicability. It is difficult for students to learn well in the process of teaching. In addition, the experimental course lacks integrity, comprehensiveness and design experiments. Under the guidance of outcome-based education (OBE) concept, we established a multi-dimensional teaching reform system through theoretically and practically introducing of various teaching methods, online courses, bilingual teaching, stronger practical teaching and optimized assessment mode. The teaching reform system could effectively allow students to change from "passive learning" to "active learning" through activating learning enthusiasm, resulting in cultivated innovation ability. This system could play very important role in promoting quality of talent training of colleges and universities.

Indication of bloodletting therapy based on multi-dimensional evidence assessment / 中国针灸

The indication of bloodletting therapy was determined based on the multi-dimensional evidence assessment, which could provide guidance for the clinical application of bloodletting therapy. The literature of bloodletting therapy was comprehensively collected by retrieval in CNKI, Wanfang and VIP databases (until February 23, 2019), modern books in Library of Tianjing University of TCM and the (Fifth Edition). The disease spectrum of bloodletting therapy was determined by self-designed questionnaire survey e-mailed to relevant experts. The indication of bloodletting therapy was determined by Delphi expert meeting. As a result, 746 pieces of ancient literature and 32 775 modern literature were included. The indications of bloodletting therapy based on the multi-dimensional evidence assessment include herpes zoster, acne, acute tonsillitis, vascular headache, varicose veins of lower extremities, acute lumbar sprain, early erysipelas, wheat swelling, exogenous fever of children, stroke, which are mainly the syndromes of blood stasis, toxin, excess and heat.

Latent relations between selected morphometric, physiological and biochemical parameters / Relaciones latentes entre parámetros morfométricos, fisiológicos y bioquímicos seleccionados

The main purpose of this study was to explore the latent relations of the selected morphometric, physiological and biochemical parameters. Thirty-six variables (12 morphometric, 9 physiological and 15 biochemical variables) were measured on 317 male-entities aged 17 - 35 y/o. The obtained data were analysed through the factor analysis of the first and second order. The statistical analyses were performed with the IBM SPSS Statistics software package, version 20. The factorization of the first order enabled extraction of 12 latent factors that explain 74.8 % of the total variance, while the factorization of the second order enabled extraction of five latent components that explain 51.39 % of the total variance. The final results of this study confirm the main hypothesis that there exist the numbers of latent variables that explain the latent structure of selected biometric measures. The nature of the extracted latent factors/ components in both orders of factorization is relatively clear, understandable, and easy to interpret. The higher projections of the manifest biometric variables on the extracted latent factors of the first and second order were accordingly with the nature of the measured variables. The results of this research might be considered as one step more in the holistic approach to the biometric measures.

El objetivo principal de este estudio fue explorar las relaciones latentes de parámetros morfométricos, fisiológicos y bioquímicos seleccionados. Treinta y seis variables (12 morfométricas, 9 fisiológicas y 15 bioquímicas) se midieron en 317 hombres de 17 a 35 años. Los datos obtenidos fueron analizados a través del análisis factorial de primer y segundo orden. Los análisis estadísticos se realizaron con el software IBM SPSS Statistics, versión 20. La factorización del primer orden permitió la extracción de 12 factores latentes que explican el 74,8 % de la varianza total, mientras que la factorización del segundo orden permitió la extracción de cinco componentes latentes que determinaron el 51,39 % de la varianza total. Los resultados finales de este estudio confirmaron la hipótesis principal de que existen números de variables latentes que explican la estructura latente de las medidas biométricas seleccionadas. La naturaleza de los factores/componentes latentes extraídos en ambos órdenes de factorización es relativamente clara, comprensible y fácil de interpretar. Las proyecciones superiores de las variables biométricas manifiestas en los factores latentes extraídos del primer y segundo orden correspondieron a la naturaleza de las variables medidas. Los resultados de esta investigación podrían considerarse como un paso más en el enfoque holístico de las medidas biométricas.

Investigation of quality of life in patients undergoing oral vestibular thyroid surgery / 中国实用护理杂志

Objective@#To explore the basic conditions and postoperative quality of life in patients undergoing oral vestibular thyroid surgery.@*Methods@#A total of 128 patients undergoing oral vestibular thyroid surgery were enrolled in the Department of Head and Neck Surgery from March 2015 to April 2018. On the basis of routine thyroid tumor care, we used telephone, WeChat public platform, WeChat group, QQ, and Email. Questionnaires such as information technology and clinic review. Correlation analysis was performed using SPSS 22.0.@*Results@#According to the analysis of SPSS statistical software, the postoperative recovery of the patients is good, and more than 95% of the patients have the feeling of "no" or "a little" for symptoms, and 91.8% (102/111) and 93.6% (104/111) of the patients have the perception of the general health status and life quality of the patients in the past 1 week respectively. Analysis of variance of postoperative life quality of patients, postoperative regression post was significantly correlated with postoperative social cognition, insomnia and economic difficulties of patients. The education level, occupation, marital status and family income of the patients all had significant influences on the postoperative economic status of the patients, and the differences were statistically significant (t=2.66-4.74, P<0.05). In the regression analysis of patients′ life quality, emotional function and physical function were independent risk factors affecting patients′ life quality, with statistical significance (t=-2.072, -5.564, P < 0.05).@*Conclusion@#Endoscopic thyroidectomy via oral vestibule has the advantages of good effect, beautiful appearance and high quality of life, which is worth popularizing and applying.

Feasibility of Multi-dimensional Visual Hand Function Rehabilitation Quantitative Assessment System in Assessing Hand Function for Stroke Patients / 中国康复理论与实践

@#Objective To investigate the feasibility of Multi-dimensional Visual Hand Function Rehabilitation Quantitative Assessment System in the assessment of hand function for stroke patients. Methods From November, 2017 to July, 2018, 17 stroke inpatients were assessed with Fugl-Meyer Assessment-upper extremities (FMA-UE) and the Multi-dimensional Assessment System. Results The results of Multi-dimensional Assessment System positively correlated with the score of FMA-UE (r = 0.609, P = 0.010). Conclusion The Multi-dimensional Visual Hand Function Rehabilitation Quantitative Assessment System can be used to assess the hand function for stroke patients quantitatively.

Prognosis of Patients with Benign Vocal Fold Lesions after Laryngeal Microsurgery

BACKGROUND AND OBJECTIVES: This study aimed to evaluate patients' subjective and objective outcomes after laryngeal microsurgery for benign vocal fold (VF) lesions, and to identify usefulness of surgical treatment. MATERIALS AND METHODS: The authors reviewed the 102 patients medical records, retrospectively who received laryngeal microsurgery for benign VF lesions from January 2013 to August 2017. Subjective voice were measured using the Voice Handicap Index (VHI). Objective voice were recorded with Multi-Dimensional Voice Program (MDVP) just before surgery, and after at least 3 months of surgery. RESULTS: Benign VF lesions were categorized as VF nodule (n=34, 33%), VF Polyp (n=47, 26%), Intracordal cyst (n=15, 15%), Reinke's edema (n=6, 6%), and VF Papilloma (n=2, 2%). Post-operative voice assessment at VHI scores showed statistically significant reductions in all of functional, physical and emotional parts (p < 0.001). MDVP were showed significant improvement of Jitter (P=0.001), Shimmer (p < 0.001) and Noise to Harmonic Ratio (NHR) (p=0.001). CONCLUSION: Laryngeal microsurgery for benign vocal fold lesions is effective treatment with statistically significant improvement at subjective and objective vocal quality assessment.

Haplotype and genetic relationship of 27 Y-STR loci in Han population of Chaoshan area of China / 解放军医学杂志

Objective To investigate the genetic polymorphisms of 27 Y-chromosomal short tandem repeats (Y-STR) loci included in Yfiler(R) Plus kit in Han population of Chaoshan area,and explore the population genetic relationships and evaluate its application value on forensic medicine.Methods By detecting 795 unrelated Chaoshan Han males with Yfiler(R) Plus kit,haplotype frequencies and population genetics parameters of the 27 Y-STR loci were statistically analyzed and compared with available data of other populations from different races and regions for analyzing the genetic distance and clustering relation of Chaoshan Han population.Results Seven hundred and eighty-seven different haplotypes were observed in 795 unrelated male individuals,of which 779 haplotypes were unique,and 8 haplotypes occurred twice.The haplotype diversity (HD) was 0.999975 with discriminative capacity (DC) of 98.99％.The gene diversity (GD) at the 27 Y-STR loci ranged from 0.3637(DYS391) to 0.9559(DYS385a/b).Comparing with Asian reference populations,the genetic distance (Rst) between Chaoshan Han and Guangdong Han was the smallest (0.0036),while it was relatively larger between Chaoshan Han and Gansu Tibetan population (0.0935).The multi-dimensional scaling (MDS) plot based on Rst values was similar to the results of clustering analysis.Conclusion Multiplex detection of the 27 Y-STR loci reveals a highly polymorphic genetic distribution in Chaoshan Han population,which demonstrates the important significance of Yfiler(R) Plus kit for establishing a Y-STR database,studying population genetics,and for good practice in forensic medicine.

Evaluation on Comprehensive Scientific Research Capability of Technology Talents and Application Study Based on Big Data of Scientific and Technological Information / 医学信息学杂志

Based on the analysis of comprehensive scientific research capability of technology talents,the paper constructs the evalu ation model of comprehensive scientific research capability of technology talents,designs the evaluating indicator system based on big data of scientific and technological information,including the 5 dimensions like basic literacy,influence of scientific research output,scientific research management capability,academic potential and academic status,and studies on its application in talent introduction.

The modification of natural products for medical use

Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different fromstructure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products.

Clinical value of multi-dimensional health assessment questionnaire in patients with rheumatoid arthritis / 中华风湿病学杂志

Objective To evaluate the clinical value of Chinese Multi-Dimensional Health Assessment Questionnaire (MDHAQ-C) in patients with rheumatoid arthritis (RA). Methods From December 2015 to October 2016,four hundred and twelve RA patients were recruited in this study and completed the MDHAQ-C independently and routine assessment of patient index data 3 (RAPID3) was calculated. Then correlations were assessed by Spearman correlation coefficient of RAPID3 with indices of clinical relevance and disease activity to evaluate its clinical values. Results MDHAQ-C is moderately correlated with ESR (r=0.399), CRP (r=0.381), SJC (r=0.499), TJC (r=0.558) (P<0.01), but highly correlation with VAS of pain (r=0.836), VAS of global status (r=0.915) and overall assessment of physician (r=0.784)(P<0.01), and highly correlated with a Spearman's coefficient of 0.784 for DAS 28-ESR, 0.734 for CDAI and 0.682 for SDAI (P<0.001). Conclusion MDHAQ is a reliable, valid instrument for disease activity assessment and a feasible index for clinical settings in Chinese RA patients.

The method of multi-dimensional medical equipment management based on the comprehensive index assessment / 中国医学装备

Objective:To explore the multi-dimensional method of medical equipment management based on comprehensive index assessment, and improve quality of medical equipment management. Methods: This essay proposed a comprehensive-index-analysis medical equipment management approach within hospital theoretic work and medical equipment management. Equipment management and project application in each clinical department were treated as evaluation criteria which conducted a multi-equality index for medical equipment operation management, using the pattern of quantitative substitute qualitative method.Results: The new method helps to quantize ability of clinical department, equipment utility and management. It refers to scientific equipment management data after procurement, which reflects differences between each department and equipments. Moreover, it helps to prevent blind procurement effectively by ranking department earning capacity.Conclusion: The new method is benefit for equipments’ evaluation and to provide reference for managers in decision-making.

Health information needs of diabetics in social Q & A community / 中华医学图书情报杂志

A total of 587 keywords expressing the health information needs of diabetics were selected from diabetes-related 8762 questions covered in Yahoo Q and A, coded according to the cataloguing system and classification strategies of diabetes information, processed by text formatting, and clustered by multi-dimensional analysis, which showed that the most concerned health information in diabetics is the daily management, diagnosis and treatment of diabetes while rare attention is paid to its prevention.

Advance in research on data processing methods of optimizing drug preparation process / 中国药学杂志

OBJECTIVE: To summarize the advance in research on a variety of data processing methods of optimizing drug preparation process. METHODS: On the basis of data processing methods of single index, this paper compares, analyzes and summarizes a variety of data processing methods in relevant literature. RESULTS: Multiple indicator data processing method, such as analysis of variance-comprehensive weighted of multi-index, multiple regression analysis-response surface methodology, artificial neural network, and multi-dimensional space triangle area, has been widely used in the optimization of drug preparation process in a certain scope. CONCLUSION: Analysis of variance-comprehensive weighted of multi-index, multiple regression analysis-response surface methodology, artificial neural networks, and multidimensional spatial triangular area can reveal the principles among multi-factors of multi-levels, thus can provide reference for optimizing drug preparation technology.

Prevalência da dor orofacial e seu impacto no desempenho diário em trabalhadores das indústrias têxteis do município de Laguna, SC / Prevalence of orofacial pain and its impact on the oral health-related quality of life of textile industries workers of Laguna, SC, Brazil

Foram examinadas as tendências em saúde da população idosa brasileira utilizando-se dados da Pesquisa Nacional por Amostra de Domicílios (1998-2008). O estudo incluiu uma amostra probabilística de 105.254 pessoas com > 60 anos de idade. A média da idade foi de 69 anos e 56 por cento eram mulheres. Houve um aumento gradativo da boa autoavaliação da saúde (39,3 por cento, 43,5 por cento e 45,0 por cento em 1998, 2003 e 2008, respectivamente) e uma diminuição na prevalência de artrite, doença do coração e depressão autorreferidas. A prevalência da hipertensão (43.9 por cento, 48.8 por cento e 53.3 por cento, respectivamente) e do diabetes autorreferidos (10.3 por cento, 13.0 por cento e 16.1 por cento respectivamente) aumentou acentuadamente. A prevalência da incapacidade para realizar atividades da vida diária (alimentar-se, tomar banho ou ir ao banheiro) permaneceu estável (6.5 por cento, 6.4 por cento e 6.9 por cento, respectivamente). A realização de três ou mais consultas médicas nos 12 meses precedentes aumentou 21 por cento entre 1998 e 2008. As hospitalizações diminuíram 10 por cento no mesmo período. Essas tendências foram independentes do sexo e da idade. Os resultados mostram melhora em algumas dimensões da saúde dos idosos, mas não em todas. As mudanças no uso de serviços de saúde ocorreram como esperado em decorrência da expansão das atividades de atenção primária no Brasil.

The aim of this study was to establish the prevalence of orofacial pain and its impact on the daily performance of workers in the textile industry in the municipality of Laguna, Brazil. A cross-sectional study involving all workers (n= 267) of the five textile industries of the municipality in 2004 was conducted. Data were obtained through the questionnaire proposed by Locker and Gruska to measure the Oral Impact on Daily Performance (OIDP) indicator. Socio-demographic data such as gender, age, level of schooling, income, job function and absenteeism due to orofacial pain was collected. Data were descriptively analyzed and the prevalence ratios, confidence intervals and unconditional multiple logistic regression were calculated. The prevalence of orofacial pain was 32.2 percent and the oral impact on daily performance was 28.5 percent. The regression model indicated that orofacial pain was the only variable statistically associated with the oral impact on daily performance, increasing its prevalence by more than 22 times, compared to those without orofacial pain. It was concluded that the prevalence of orofacial pain was high among workers, representing a decisive factor on the oral impact on daily performance.

Tendências em dez anos das condições de saúde de idosos brasileiros: evidências da Pesquisa Nacional por Amostra de Domicílios (1998, 2003, 2008) / 10-year trends in the health of Brazilian elderly: evidence from the National Household Sample Survey (PNAD 1998, 2003, 2008)

Foram examinadas as tendências em saúde da população idosa brasileira utilizando-se dados da Pesquisa Nacional por Amostra de Domicílios (1998-2008). O estudo incluiu uma amostra probabilística de 105.254 pessoas com > 60 anos de idade. A média da idade foi de 69 anos e 56 por cento eram mulheres. Houve um aumento gradativo da boa autoavaliação da saúde (39,3 por cento, 43,5 por cento e 45,0 por cento em 1998, 2003 e 2008, respectivamente) e uma diminuição na prevalência de artrite, doença do coração e depressão autorreferidas. A prevalência da hipertensão (43.9 por cento, 48.8 por cento e 53.3 por cento, respectivamente) e do diabetes autorreferidos (10.3 por cento, 13.0 por cento e 16.1 por cento respectivamente) aumentou acentuadamente. A prevalência da incapacidade para realizar atividades da vida diária (alimentar-se, tomar banho ou ir ao banheiro) permaneceu estável (6.5 por cento, 6.4 por cento e 6.9 por cento, respectivamente). A realização de três ou mais consultas médicas nos 12 meses precedentes aumentou 21 por cento entre 1998 e 2008. As hospitalizações diminuíram 10 por cento no mesmo período. Essas tendências foram independentes do sexo e da idade. Os resultados mostram melhora em algumas dimensões da saúde dos idosos, mas não em todas. As mudanças no uso de serviços de saúde ocorreram como esperado em decorrência da expansão das atividades de atenção primária no Brasil.

Data from a representative national household survey were used to examine 10-year trends (1998-2008) in health conditions of Brazilian elderly. A random sample of 105,254 individuals aged > 60 years participated. The mean age was 69 years and 56 percent were women. There was a gradual increase in the prevalence of good or excellent self-rated health (39.3 percent, 43.5 percent and 45.0 percent, in 1998, 2003 and 2008, respectively) and a decrease in self-reported arthritis, heart disease, and depression. The prevalence of self-reported hypertension (43.9 percent, 48.8 percent, and 53.3 percent, respectively) and diabetes (10.3 percent, 13.0 percent and 16.1 percent respectively) increased sharply. The prevalence of inability to perform activities of daily living (eating, bathing or using the toilet) remained stable (6.5 percent, 6.4 percent and 6.9 percent, respectively). The achievement of three or more physician visits over the previous 12 months increased by 21 percent from 1998 to 2008. Hospitalization decreased by 10 percent in the corresponding period. The above mentioned trends persisted after adjustments for age and sex. The results showed improvements in some health dimensions of the elderly, but not all. Changes in the use of health services occurred as expected with the expansion of primary healthcare activities in Brazil.

Advance in Evaluation on Speech and Phonation in Dysarthria（review） / 中国康复理论与实践

@#Dysarthria is collective name for motor speech disorders resulting from disturbance in the speech control mechanism due to the damage to the central or peripheral nervous systems. The speech intelligibility (SI) and communication ability of dysarthric patient are affected, impacting quality of life. Evaluation of dysarthric speech involves subjective and objective measurement which contains electrolaryngoscope, glottograph, electropalatography, nasalance evaluation, acoustic analysis including sonogram，spectrogram, perturbation and noise measurements. Multi-Dimensional Voice Program (MDVP) is a commonly used quantitative acoustic analysis of dysarthric speech. However, in the mainland of China, it is applied in researches on voice of normal people and patients with laryngological diseases and researches on voice characteristics of patients with Parkinson disease or cerebral palsy. To date, no study on the acoustic analysis using MDVP for dysarthric patients with cerebrovascular disease or traumatic brain injury is reported.