Clinical analysis of multi-mode CT-guided mechanical thrombectomy in the treatment of acute anterior circulation cerebral infarction caused by cardiogenic embolism / 中风与神经疾病杂志

@#Objective To evaluate the efficacy of mechanical thrombectomy under the guidance of multi-mode computed tomography in the treatment of acute anterior circulation cerebral infarction caused by cardiogenic embolism.Methods We retrospectively analyzed the baseline and follow-up data of patients with cardiogenic acute anterior circulation ischemic stroke treated with mechanical thrombolectomy.According to the preoperative evaluation,the patients were divided into MMCT group and NCCT group.The efficacy was analyzed by comparing the vascular revascularization rate,NIHSS score and 3-month Modified Rankin Scale (mRS) score of the two groups,and the safety was analyzed by comparing the conversion risk and mortality of symptomatic bleeding.Multivariate logistic regression was used to analyze the factors affecting the prognosis of patients.Results A total of 118 eligible patients were finally included,including 58 in MMCT group and 60 in NCCT group.There was no significant difference in the proportion of functionally independent patients between the two groups 3 months after surgery (58.9% vs 31.7% P=0.034),and no significant difference in symptomatic intracranial hemorrhage transformation and mortality (P>0.05).Multivariate regression analysis showed that MMCT and baseline NIHSS score were independent prognostic factors. Conclusion Mechanical thrombectomy under the guidance of multi-mode CT evaluation does bring better clinical prognosis for patients with acute anterior circulation cerebral infarction caused by cardiac embolism.MMCT and baseline NIHSS score are closely related to the prognosis of patients with acute anterior circulation cerebral infarction caused by cardiac embolism.Future studies are needed to further verify the above conclusions.

Application research on multi-mode teaching guided by objective management in the standardized training of nursing students in the department of oncology / 中华医学教育探索杂志

Objective:To explore the application effect of multi-mode teaching guided by objective management in the standardized training of nursing students.Methods:A total of 39 standardized training nursing students from April 2019 to April 2020 in the department of oncology of a tertiary hospital were selected as the control group by cluster sampling method and they received traditional teaching; 40 standardized nursing students in the department of oncology from June 2020 to June 2021 were selected as the experimental group and the group adopted multi-mode teaching guided by objective management. The differences of theoretical and operational assessment scores, teaching satisfaction, critical thinking ability and nurse-patient communication ability between the two groups were studied. SPSS 20.0 was used for t-test and Chi-square test. Results:The scores of theoretical assessment [(86.17±3.74) vs. (83.92±4.93)] and operational assessment [(92.83±2.19) vs. (90.74±3.52)] in the experimental group were higher than those in the control group, and the differences were statistically significant ( P<0.05). The teaching satisfaction of the experimental group was higher than that of the control group [(46.10±2.96) vs. (42.67±2.45)], and the difference was statistically significant ( P<0.05). There were statistically significant differences in critical thinking, intellectual curiosity and analytical skills ( P<0.05). In terms of nurse-patient communication ability, except that there was no difference in collecting information, the rest were statistically significant( P<0.05). Conclusion:Multi-mode teaching guided by objective management can improve the theoretical and operational ability of nurses, nurse-patient communication ability, and teaching satisfaction.

Therapeutic effect of artificial liver multi-mode sequential combination in patients with hepatitis B virus-related acute-on-chronic liver failure / 中华传染病杂志

Objective:To explore the therapeutic effect of multi-mode sequential combination of artificial liver in the treatment of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Methods:The clinical data of HBV-ACLF patients treated with artificial liver in Wuxi Fifth People′s Hospital from January 2018 to June 2021 were retrospectively analyzed. Eighty-six patients were divided into artificial liver multi-mode sequential combination therapy group (sequential combination group) and conventional treatment group. The cytokine level changes and model for end-stage liver disease (MELD) score were analyzed at 14 days of disease duration. The survival outcome and complications of artificial liver were analyzed after 30 days of follow-up. Two independent samples t test and chi-square test were used for statistical analysis. Cox regression analysis was used to analyze the risk factors of death, and Kaplan-Meier method was used to analyze the survival rate of patients. Results:A total of 86 patients were enrolled, including 48 patients in sequential combination group with the average number of artificial liver of 4.68 times/person, and 38 patients in conventional treatment group with the average number of artificial liver of 3.17 times/person. At 14 days of disease duration, interleukin (IL)-6, IL-8, interferon γ-inducible protein (IP)-10 level and MELD score in sequential combination group decreased significantly than those in the conventional treatment group ( t=3.80, 3.62, 4.95 and 1.11, respectively, all P<0.050). After 30 days of follow-up, 63 patients survived and 23 patients died. Cox regression analysis showed that baseline international normalized ratio (hazard ratio ( HR)=0.558, 95% confidence interval ( CI) 0.193 to 0.856, P=0.027), baseline antithrombin Ⅲ activity ( HR=0.876, 95% CI 0.824 to 0.932, P<0.001), artificial liver mode ( HR=0.819, 95% CI 0.236 to 0.992, P=0.005), spontaneous peritonitis ( HR=0.170, 95% CI 0.045 to 0.647, P=0.009) and hepatic encephalopathy ( HR=0.004, 95% CI 0.001 to 0.030, P<0.001) were independent influencing factors for 30-day survival outcome. The cumulative survival rate of sequential combination group was higher than that of conventional treatment group, and the difference was statistically significant ( χ2=5.45, P=0.020). There were no significant differences in the proportions of bleeding, deep vein thrombosis, heart rate and blood pressure instability between the two groups ( χ2=0.63, 1.20 and 0.54, respectively, all P>0.050). The platelet decline of patients in sequential combination group was slighter than that in conventional treatment group, and the difference was statistically significant ( t=-4.17, P=0.002). Conclusions:Multi-mode sequential combination therapy of artificial liver could eliminate cytokines and reduce MELD score more effectively in patients with HBV-ACLF, and prolong the survival time of patients and have little effect on platelet count.

Application of multi-mode combined analgesia in the early stage of non-operative treatment of traumatic rib fractures in adults / 中华胸心血管外科杂志

Objective To evaluate the analgesic effect of a new combined analgesic mode in the early stage of non-opera-tive treatment of adult traumatic rib fractures. Methods A total of 93 patients with rib fractures who did not receive surgical treatment from January 2014 to January 2018 were prospectively included, and randomly divided into the traditional analgesia group, subcutaneous analgesia group and combined analgesia group(31 cases each). There were 56 males and 37 females total-ly with a median age of(47.3 ±13.2)years. All patients have moderate to severe pain with VAS scores greater than 5. Tradi-tional analgesia group: lornoxicam 8 mg intravenous injection twice daily. Subcutaneous analgesia group: only subcutaneous self-controlled analgesia pump was used for treatment. Combined analgesia group: on the basis of the traditional analgesia group, subcutaneous self-controlled analgesia pump was added for treatment, and the dosage of the pump drug was the same as that of subcutaneous analgesia group. The VAS scores at tranquillization and cough were compared before analgesia treatment (T1), 24 h(T2), 48 h(T3) and 72 h(T4) after analgesic treatment in each group during bed brake within 3 days after inju-ry. The VAS scores after 78 hours of analgesic treatment during ambulation were compared. When sudden pain with VAS score greater than 7 occurred within 72 hours of bed staying treatment in each group, the average daily use times of bucinnazine hydrochloride 100mg remedial analgesia were compared. The number of adverse reactions such as nausea and pneumonia in each group was compared. Results The VAS scores of resting pain and cough pain at the observation time point(T2-T4) in the combined analgesia group were better than those in the subcutaneous analgesia group and the traditional analgesia group, showing a significant difference(P<0. 05). When getting out of bed, there were significant differences in pain scores among the three groups, and the pain score of the combined analgesia group was the lowest. There was a significant difference among the three groups in the number of daily additions of bucinnazine hydrochloride during remedial analgesia(P<0. 05),the com-bined analgesia group was the least. Between the two groups of patients using analgesic pump, the number of self-compressions in the combined analgesia group was lower than that in the subcutaneous analgesia group(P<0. 05). The incidence of pneumo-nia in the combined analgesia group was lower than that in the other two groups and the incidence of other adverse reactions such as nausea was lower than that in the simple analgesia group. Conclusion In the early stage of non-operative treatment of traumatic rib fractures in adults, the multi-mode analgesic effect of traditional intravenous intermittent administration combined with subcutaneous continuous administration is superior to the single analgesic mode of traditional intravenous or subcutaneous administration with no obvious adverse reactions.

Application of multi-mode combined analgesia in the early stage of non-operative treatment of traumatic rib fractures in adults / 中华胸心血管外科杂志

Objective@#To evaluate the analgesic effect of a new combined analgesic mode in the early stage of non-operative treatment of adult traumatic rib fractures.@*Methods@#A total of 93 patients with rib fractures who did not receive surgical treatment from January 2014 to January 2018 were prospectively included, and randomly divided into the traditional analgesia group, subcutaneous analgesia group and combined analgesia group(31 cases each). There were 56 males and 37 females totally with a median age of(47.3±13.2)years. All patients have moderate to severe pain with VAS scores greater than 5. Traditional analgesia group: lornoxicam 8 mg intravenous injection twice daily. Subcutaneous analgesia group: only subcutaneous self-controlled analgesia pump was used for treatment. Combined analgesia group: on the basis of the traditional analgesia group, subcutaneous self-controlled analgesia pump was added for treatment, and the dosage of the pump drug was the same as that of subcutaneous analgesia group. The VAS scores at tranquillization and cough were compared before analgesia treatment(T1), 24 h(T2), 48 h(T3) and 72 h(T4) after analgesic treatment in each group during bed brake within 3 days after injury. The VAS scores after 78 hours of analgesic treatment during ambulation were compared. When sudden pain with VAS score greater than 7 occurred within 72 hours of bed staying treatment in each group, the average daily use times of bucinnazine hydrochloride 100mg remedial analgesia were compared. The number of adverse reactions such as nausea and pneumonia in each group was compared.@*Results@#The VAS scores of resting pain and cough pain at the observation time point(T2-T4) in the combined analgesia group were better than those in the subcutaneous analgesia group and the traditional analgesia group, showing a significant difference(P<0.05). When getting out of bed, there were significant differences in pain scores among the three groups, and the pain score of the combined analgesia group was the lowest. There was a significant difference among the three groups in the number of daily additions of bucinnazine hydrochloride during remedial analgesia(P<0.05), the combined analgesia group was the least. Between the two groups of patients using analgesic pump, the number of self-compressions in the combined analgesia group was lower than that in the subcutaneous analgesia group(P<0.05). The incidence of pneumonia in the combined analgesia group was lower than that in the other two groups and the incidence of other adverse reactions such as nausea was lower than that in the simple analgesia group.@*Conclusion@#In the early stage of non-operative treatment of traumatic rib fractures in adults, the multi-mode analgesic effect of traditional intravenous intermittent administration combined with subcutaneous continuous administration is superior to the single analgesic mode of traditional intravenous or subcutaneous administration with no obvious adverse reactions.

Research on hand health intervention strategy of organ transplant ICU medica personnel / 中国实用护理杂志

Objective@#To investigate the impact of WHO multimodal hand hygiene improvement strategy (MHHIS) on improving hand hygiene compliance of medical staff of organ transplant ICU.@*Methods@#According to the WHO MHHIS, the hand hygiene compliance and correctness before and after intervention of the medical staff was investigated by using double covert observation method from January 2017 to December 2017. The intervention methods included strengthening education and training, improving hand-washing facilities, setting up hand hygiene reminders, adopting feedback mechanisms, and implementing the PDCA cycle. SPSS software was used to statistically analyze the data before and after the intervention.@*Results@#After the intervention, the rates of compliance and correct hand hygiene of organ transplant ICU medical personnel improved from 22.63%(86/380) and 53.49%(46/86) before intervention to 59.31%(309/521) and 79.94%(247/309) after intervention respectively (χ2=120.060,24.566, P<0.01). The rates of compliance of doctors, nurses, interns, and care workers improved from20.45%(9/44),23.53%(68/289), 21.88%(7/32), and 13.33%(2/15) to 44.83%(26/58), 61.85%(167/270), 66.94%(83/124), and 58.62%(34/58), the differences were statistically significant (χ2=6.594-84.133, P<0.05 or 0.01). The difference in the correct rate of hand hygiene between nurses and care workers was statistically significant (χ2=19.541,10.588,P<0.05), but there was no significant difference in the correct rate of hand hygiene between doctors and interns (χ2=1.353, 0.177, P>0.05). The compliance rate of hand hygiene was 15.38%(22/143), 9.90%(11/111), 27.27%(9/33), 26.97%(41/152), 18.26%(21/115), respectively, before the intervention before the patients, before the aseptic operation, after exposure to the blood body fluid, after contact with the patients, and after contact with the surrounding environment. After the intervention, they were 47.59%(79/166), 38.46%(50/130), 65.82%(52/79), 73.04%(168/230), 61.25%(98/160), the difference was statistically significant (χ2=13.948-78.393, P<0.01 The average daily consumption per day of the department's hand-dried hand sanitizers and antibacterial soaps increased from 4.54 ml and 2.59 ml before intervention to 6.48 ml and 4.15 ml after intervention.@*Conclusions@#The WHO MHHIS can effectively improve the hand hygiene compliance of the medical personnel of organ transplant ICU.

Research on hand health intervention strategy of organ transplant ICU medica personnel / 中国实用护理杂志

Objective To investigate the impact of WHO multimodal hand hygiene improvement strategy (MHHIS) on improving hand hygiene compliance of medical staff of organ transplant ICU. Methods According to the WHO MHHIS, the hand hygiene compliance and correctness before and after intervention of the medical staff was investigated by using double covert observation method from January 2017 to December 2017. The intervention methods included strengthening education and training, improving hand-washing facilities, setting up hand hygiene reminders, adopting feedback mechanisms, and implementing the PDCA cycle. SPSS software was used to statistically analyze the data before and after the intervention. Results After the intervention, the rates of compliance and correct hand hygiene of organ transplant ICU medical personnel improved from 22.63% (86/380) and 53.49% (46/86) before intervention to 59.31% (309/521) and 79.94% (247/309) after intervention respectively (χ2＝120.060, 24.566﹐P<0.01). The rates of compliance of doctors, nurses, interns, and care workers improved from 20.45% (9/44),23.53% (68/289), 21.88% (7/32), and 13.33% (2/15) to 44.83% (26/58), 61.85% (167/270), 66.94%(83/124), and 58.62%(34/58), the differences were statistically significant (χ2＝6.594-84.133, P<0.05 or 0.01). The difference in the correct rate of hand hygiene between nurses and care workers was statistically significant (χ2＝19.541,10.588,P<0.05), but there was no significant difference in the correct rate of hand hygiene between doctors and interns (χ2＝1.353, 0.177, P＞0.05). The compliance rate of hand hygiene was 15.38% (22/143), 9.90% (11/111), 27.27% (9/33), 26.97% (41/152), 18.26% (21/115), respectively, before the intervention before the patients, before the aseptic operation, after exposure to the blood body fluid, after contact with the patients, and after contact with the surrounding environment. After the intervention, they were 47.59 %(79/166), 38.46%(50/130), 65.82%(52/79), 73.04%(168/230), 61.25% (98/160), the difference was statistically significant (χ2＝13.948-78.393, P<0.01 The average daily consumption per day of the department's hand-dried hand sanitizers and antibacterial soaps increased from 4.54 ml and 2.59 ml before intervention to 6.48 ml and 4.15 ml after intervention. Conclusions The WHO MHHIS can effectively improve the hand hygiene compliance of the medical personnel of organ transplant ICU.

Development and Testing of Multi-mode Elbow Joint Muscle Strength Training Device / 中国医疗器械杂志

Muscle strength training plays an important role in improving limb movement function, preventing muscle atrophy and promoting muscle function recovery in patients with various bone and joint diseases. The sports function of elbow joint is closely related to people's daily life activity ability. At present, Chinese muscle strength training devices are depended on import. Therefore, it is of great significance to develop muscle strength training devices. Based on the concepts and characteristics of isometric training, isotonic training, passive training and isokinetic training, in the upper computer, the servo driver and servo motor are controlled through the LabView interface, and the real-time torque is detected by the torque sensor, realizing four training modes. The main parameters of the multi-mode elbow joint muscle strength training device meet the requirements, and the trainers have a good experience.

Comparison of bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and a universal adhesive

OBJECTIVES: The aim of this study is to compare the shear bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and universal adhesive. MATERIALS AND METHODS: Fifty zirconia blocks (15 × 15 × 10 mm, Zpex, Tosoh Corporation) were polished with 1,000 grit sand paper and air-abraded with 50 µm Al2O3 for 10 seconds (40 psi). They were divided into 5 groups: control (CO), Metal/Zirconia primer (MZ, Ivoclar Vivadent), Z-PRIME Plus (ZP, Bisco), Zirconia Liner (ZL, Sun Medical), and Scotchbond Universal adhesive (SU, 3M ESPE). Transbond XT Primer (used for CO, MZ, ZP, and ZL) and Transbond XT Paste was used for bracket bonding (Gemini clear ceramic brackets, 3M Unitek). After 24 hours at 37°C storage, specimens underwent 2,000 thermocycles, and then, shear bond strengths were measured (1 mm/min). An adhesive remnant index (ARI) score was calculated. The data were analyzed using one-way analysis of variance and the Bonferroni test (p = 0.05). RESULTS: Surface treatment with primers resulted in increased shear bond strength. The SU group showed the highest shear bond strength followed by the ZP, ZL, MZ, and CO groups, in that order. The median ARI scores were as follows: CO = 0, MZ = 0, ZP = 0, ZL = 0, and SU = 3 (p < 0.05). CONCLUSIONS: Within this experiment, zirconia primer can increase the shear bond strength of bracket bonding. The highest shear bond strength is observed in SU group, even when no primer is used.

Application and evaluation of early drinking and eating for gastric cancer patients with multi-mode health propaganda and education during postoperative ERAS / 肠外与肠内营养

Objective:To explore the effect of early drinking and eating for gastric cancer patients with multimode health propaganda and education during postoperative Enhanced Recovery After Surgery (ERAS).Methods:Sixty patients who would received radical operation of gastric cancer were randomly divided into two groups:observation group (30 cases) and control group (30 cases).Patients in the observation group were employed the multi-mode health propaganda and education which were guided more detailed and quantitative regimens for early drinking and eating.Patients in the control group were carried out with routine methods.The compliance of postoperative drinking and eating,the rate of complications and patients satisfaction were compared between the two groups.Results:The compliance of postoperative drinking and eating of the observation group was significantly higher than that of the control group.Hospital patient satisfaction in health-education projects (19.50 ± 0.50) of the observation group was significantly higher than that (16.12 ± 3.21) of the control group (P ＜ 0.05).The rate of gastrointestinal complications in the observation patients was significantly lower,compared with that in the control patients (P ＜ 0.05).Conclusion:During the postoperative ERAS for gastric cancer patients,early drinking and eating guided by multi-mode health propaganda and education is safe and effective,for which could increase the postoperative compliance,decrease the rate of complication.It is worth promoting early quantitative drinking and eating after operation.

Research on the innovative mode of comprehensive ability training for the Chinese medicine majors based on the combination of "multi-mode and multi-ways" / 国际中医中药杂志

Chinese medicine talents are the foundation and guarantee for the development of TCM, and the first resource for the inheritance and innovation of traditional Chinese medicine. Reforming the curriculum system and training mode of Chinese medicine, training Chinese medicine professional who are suitable for research and development of Chinese medicine, such as cultivation of Chinese medicine materials, quality detection, species identification and resource census, is the direction of further expansion and reformation of Chinese medicine education. In this article, on account of the characteristic of Chinese medicine professional courses, we will combine practice education mode with professional knowledge competition, to probe innovative mode of comprehensive ability training for Chinese medicine based on the combination of"Multi-mode and Multi-Ways". The new mode of Chinese medicine education is to provide reference for trainers of Chinese medicine.

Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis

OBJECTIVES: The aims of this study were to conduct a systematic review of the microtensile bond strength (µTBS) of multi-mode adhesives to dentin and to perform a meta-analysis to assess the significance of differences in the µTBS of one of the most commonly used universal adhesives (Scotchbond Universal, 3M ESPE) depending on whether the etch-and-rinse or self-etch mode was used. MATERIALS AND METHODS: An electronic search was performed of MEDLINE/PubMed, ScienceDirect, and EBSCOhost. Laboratory studies that evaluated the µTBS of multi-mode adhesives to dentin using either the etch-and-rinse or self-etch mode were selected. A meta-analysis was conducted of the reviewed studies to quantify the differences in the µTBS of Scotchbond Universal adhesive. RESULTS: Only 10 studies fulfilled the inclusion criteria for the systematic review. Extensive variation was found in the restorative materials, testing methodologies, and failure mode in the reviewed articles. Furthermore, variation was also observed in the dimensions of the microtensile testing beams. The meta-analysis showed no statistically significant difference between the etch-and-rinse and self-etch modes for Scotchbond Universal adhesive (p > 0.05). CONCLUSIONS: Multi-mode ‘universal’ adhesives can achieve substantial bonding to dentin, regardless of the used modes (either etch-and-rinse or self-etch).

Review: optically-triggered phase-transition droplets for photoacoustic imaging

Optically-triggered phase-transition droplets have been introduced as a promising contrast agent for photoacoustic and ultrasound imaging that not only provide significantly enhanced contrast but also have potential as photoacoustic theranostic molecular probes incorporated with targeting molecules and therapeutics. For further understanding the dynamics of optical droplet vaporization process, an innovative, methodical analysis by concurrent acoustical and ultrafast optical recordings, comparing with a theoretical model has been employed. In addition, the repeatability of the droplet vaporization-recondensation process, which enables continuous photoacoustic imaging has been studied through the same approach. Further understanding the underlying physics of the optical droplet vaporization and associated dynamics may guide the optimal design of the droplets. Some innovative approaches in preclinical studies have been recently demonstrated, including sono-photoacoustic imaging, dual-modality of photoacoustic and ultrasound imaging, and super-resolution photoacoustic imaging. In this review, current development of optically triggered phase-transition droplets and understanding on the vaporization dynamics, their applications are introduced and future directions are discussed.

Effect of Different Silane Treatments on Long-Term Bonding Between Non-Etched Glass-Ceramic and Resin Cement

he present study evaluated the bond strength between glass-ceramic and resin cement, using different silane treatments, performing no previous hydrofluoric acid (HF) etching on ceramic surface, after short- and long- term storage. One hundred and eighty glass-ceramic plaques (IPS e.max CAD®) were polished and divided into six groups (n=30) to receive different silane treatments: (1) RCP-RelyX Ceramic Primer® (one-bottle silane), (2) RCP+SB-RelyX Ceramic Primer and Adper Singlebond2® (silane plus separated adhesive), (3) SBU-Scotchbond Universal® (silane-containing universal adhesive), (4) CP-Clearfil Ceramic Primer® (silane/MDP primer), (5) NC-no-silane (negative control) and (6) PC-Previous HF etching (5%, 20s) plus RelyX Ceramic Primer® (positive control). Two resin cement cylinders (Rely X Ultimate®) were built on each plaque. Each group was divided into two sub-groups to be stored for 24 hours (24h) or 6 months (6mo) in distilled water at 37°C (n=15). Then microshear (µSBS) testing was performed. Failure mode was analyzed using scanning electron microscopy (SEM). Data were statistically analyzed by two-way ANOVA and Tukey´s test (α=0.05). Both factors and their interaction resulted statistically significant (p≤0.05). PC obtained the highest µSBS values (in MPa) at both storage times (24h: 28.11±2.44; 6mo: 19.10±3.85). After 24h storage, groups RCP+SB (10.86±3.62), SBU (8.37±4.33) and CP (8.05±3.62) were not statistically different from NC (8.00±2.51); only RCP (19.73±4.63) and PC obtained higher values. After 6 months, only PC showed higher values than NC (0.04±0.01). Cohesive failure in resin cement was more prevalent for RCP-24h and PC, while adhesive failure was more frequent among all other groups. Clinical relevance: None of the commercially available silane primers tested, improve long- term ceramic/cement bonding without performing HF etching on ceramic surface. Combination of HF acid and silane, remain as a gold standard treatment for glass-ceramic materials.

ste estudio evaluó la resistencia de unión entre cerámica vítrea y cemento resinoso, utilizando diferentes tratamientos de silano, sin realizar condicionamiento previo de la cerámica con ácido fluorhídrico (HF), después de almacenamiento en corto y largo plazo. Ciento ochenta placas de cerámica (IPS e.max CAD®) fueron pulidas y divididas en 6 grupos (n=30) para ser tratadas como sigue: (1) RCPRelyX Ceramic Primer® (silano de 1 frasco), (2) RCP+SB-RelyX Ceramic Primer y Adper Singlebond2® (silano más adhesivo separado), (3) SBU-Scotchbond Universal® (adhesivo universal conteniendo silano), (4) CP-Clearfil Ceramic Primer® (primer cerámico conteniendo silano y MDP), (5) NC-ningún silano (control negativo) y (6) PC-Condicionamiento con HF previo (5%, 20s) y silano (RelyX Ceramic Primer®) (control positivo). Dos cilindros de cemento resinoso (Rely X Ultimate®) fueron construidos en cada placa. Cada grupo fue dividido en 2 sub-grupos para ser almacenados por 24 horas (24h) y 6 meses (6mo) en agua destilada a 37°C (n=15). Luego fue realizada la prueba de microcizallamiento (µSBS). El tipo de fractura fue analizado con microscopio electrónico de barrido (SEM) y los datos analizados con las pruebas estadísticas ANOVA de dos factores y Tukey (α=0.05). Ambos factores y su interacción resultaron estadísticamente significativos (p≤0.05). PC presentó los valores más altos de µSBS (MPa) para ambos tiempos de almacenamiento (24h: 28.11±2.44; 6mo: 19.10±3.85). Luego de 24h, los grupos RCP+SB (10.86±3.62), SBU (8.37±4.33) y CP (8.05±3.62) no fueron estadísticamente diferentes del grupo control negativo (NC: 8.00±2.51); sólo RCP (19.73±4.63) y PC obtuvieron resultados mayores. Después de 6 meses de almacenaje, sólo el grupo PC obtuvo valores estadísticamente mayores que NC (0.04±0.01). Fractura cohesiva en el cemento fue más prevalente para RCP-24h y PC, mientras que el tipo adhesivo fue el más frecuente para todos los demás grupos. Relevancia Clínica: Ninguno de los tratamientos de silano evaluados, mejoró significativamente la adhesión a largo plazo entre cerámica vítrea no condicionada y cemento resinoso. La combinación de HF y silano, continúa siendo el tratamiento de preferencia para cerámica vítrea durante el proceso de cementación.

Mechanism research about the role of microbleeds for early cognitive impairment in small vascular disease / 上海交通大学学报（医学版）

Objective·To make clear the role of cerebral microbleeds (CMBs) for early cognitive impairment in small vessel disease (SVD). Methods·Fifty-seven consecutive SVD patients without dementia were strictly recruited. All participants were examined with a comprehensive battery of neuropsychological tests, SWI and DTI. According to the amount of CMBs, the patients were divided into CMBs group and non-CMBs group, or divided into multiple CMBs group (CMBs ≥ 3) and non-multiple CMBs group (CMBs<3). The mean diffusivity (MD) and fractional anisotropy (FA) in periventricular, central semiovale and subcortical white matter was analyzed with a region-of-interest method. Results·The score of multiple CMBs group in attention and memory function was significantly lower than that of the non-multiple CMBs group. Correlation analysis showed that the count of CMBs in the whole brain was significantly correlated with periventricular white matter MD, subcortical white matter MD, periventricular white matter FA and subcortical white matter FA. The count of CMBs in the whole brain adjusted by age, gender, education was significantly correlated with attention/executive function. After adjustment of subcortical/ periventricular white matter FA and MD and locations of CMBs they still had significant correlation. Conclusion·CMBs can reflect the degree of destruction of white matter integrity, and have independent effects on injury of brain parenchyma, resulting in early cognitive impairment. The research also suggests the role of CMBs in cognitive impairment may exist threshold value effect.

Application prospects of monitoring of brain function and diagnosis of brain injury in premature infants based on multimodal data / 中华实用儿科临床杂志

It is critical to assess the development and injury of brain function in premature infants in early stage.Currently,brain development and brain injury are evaluated by many ways and mainly by kinds of imaging and behavioral neurological assessment.The integrated application of these examination methods have been explored for years.The combination of resting-state functional magnetic resonance imaging and electroencephalography has prominent advantages,because they do not need to perform specific tasks,and they are noninvasive and non-toxic for preterm infants.Based on the support vetor machine learning of artificial intelligence technology,the typical characteristics of 2 multimodal data can be integrated and a multimodal assessment system which automatically monitor and predict premature infants' brain function development and injury can be established.

Non-invasive treatment to grade 1 essential hypertension by percutaneous laser and electric pulse to acupoint with music: A randomized controlled trial / 中国结合医学杂志

<p><b>OBJECTIVE</b>To study a non-drug therapy for hypertension disease by combining percutaneous laser and electric pulse stimulation to acupoint with music, and to test the efficiency of the combining treatment to grade 1 essential hypertension.</p><p><b>METHODS</b>A total of 174 patients with grade 1 essential hypertension were randomly assigned to 3 groups with a random number table after Chinese medicine (CM) syndrome differentiation: the photoelectric and musical treatment group (Group 1, with a self-developed multi-mode audio frequency pulse photoelectric therapeutic apparatus), acupuncture group (Group 2), and oral placebo group (Group 3), 58 cases per group. The curative effect of each group was evaluated by the changes of blood pressure and CM syndrome integral before and after treatment.</p><p><b>RESULTS</b>Compared with Group 3, there were significant decrease of blood pressure and CM syndrome integral in Group 1 and Group 2 (P<0.01). Compared with Group 2, Group 1 showed the highest decrease in systolic pressure (P<0.017). The total effective rate of anti-hypertension in Group 1 (91.38%, 53/58) was significantly higher than that in Group 2 (74.13%, 43/58) and Group 3 (18.97%, 11/58, P<0.05 or P<0.01); and that in Group 2 was also significantly higher than that in Group 3 (P<0.01). There were significant difference in the total effective rate of CM syndrome integral in both Group 1 (93.10%, 54/58) and Group 2 (84.48%, 49/58) as compared with Group 3 (17.24%, 10/58, P<0.01), while there was no significant difference between Group 1 and Group 2 (P>0.05).</p><p><b>CONCLUSIONS</b>The multi-mode audio frequency pulse photoelectric therapeutic apparatus, combining music, laser and electric pulse stimulation, is clinically useful for grade 1 essential hypertension. This "three in one" therapy method is non-invasive, easy and simple to handle. It is expected to be popularized as a new alternative treatment.</p>

Design and Application of the Multi-mode Diagnosing Distribution System / 医学信息学杂志

〔Abstract〕 The paper analyzes problems existing in the traditional outpatient diagnosing distribution process of hospitals , redesigns and optimizes the triage process .It designs a unified diagnosing distribution system , introduces the advantages , system composition , queuing rules and treatment priority strategies of the optimized process , and illustrates the application effects of the diagnosing distribution system with the outpatient of obstetrics and gynecology department of a large grade -III level-a hospital as an example .

Multi-mode microwave assisted preparation of PEGylated polystyrene resin / 国际药学研究杂志

Objective: To study a method of microwave-assistant PEGylation of polystyrene resin. Methods: Modify the commercial Merrifield resin with PEG-200, and study the influence of the yield under different conditions. The self-prepared PEG resin was further derived to PEG-wang resin; kinds of amino acids were anchored, and the loading rates were compared with commercial wang resin. Result: A general series react conditions were preferred, which was performed with 5 g resin, 50 ml PEG-200. irradiating for 15 min×2 at 600 W, preset temperature was 170 °C. The resin was then transformed to PEGylated Wang resin and anchored with amino acids, the yields were satisfied. Conclusion: The multi-mode microwave assistant PEGylation of Merrifield resin method was first reported in this paper. This method has the advantages of simple operation, fast preparation, mild reaction conditions and good yield, which was much better than the traditional method.

Multi-mode microwave assisted preparation of PEGylated polystyrene resin / 国际药学研究杂志

Objective To study a method of microwave-assistant PEGylation of polystyrene resin. Methods Modify the commercial Merrifield resin with PEG-200, and study the influence of the yield under different conditions. The self-prepared PEG resin was further derived to PEG-wang resin; kinds of amino acids were anchored, and the loading rates were compared with commercial wang resin. Result A general series react conditions were preferred, which was performed with 5 g resin, 50 ml PEG-200, irradiating for 15 min ×2 at 600 W, preset temperature was 170 ℃. The resin was then transformed to PEGylated Wang resin and anchored with amino acids, the yields were satisfied. Conclusion The multi-mode microwave assistant PEGylation of Merrifield resin method was first reported in this paper. This method has the advantages of simple operation,fast preparation, mild reaction conditions and good yield, which was much better than the traditional method.