Chordoid Meningioma, Part of a Multiple Intracranial Meningioma: A Case Report & Review

Chordoid meningioma, classified as atypical meningioma according to the World Health Organisation (WHO) classification, is a rare subtype, which represents only 0.5% of all meningiomas and is associated with a high incidence of recurrence. Multiple intracranial meningiomas are rare in non-neurofibromatosis patients. We present a female patient with both of these rare types of meningioma. The patient presented with two concurrent intracranial meningiomas, with one a meningotheliomatous subtype and the other a chordoid meningioma. Given the wide array of histological differential diagnoses in chordoid meningioma, immunohistochemistry has a significant role to play in differentiating them. Recurrence in chordoid meningioma can be generally predicted based on the extent of resection, the percentage of chordoid element, and proliferation indices.

The clinical and histological study of multiple memingiomas / 医学研究生学报

Objective:To study the clinical and histological features of multiple meningiomas. Methods:39 cases of multiple meningiomas were analyzed retrospectively. The expressions of PR (Progesterone receptor) , p53 and MIB-1 were detected by immunohistochemistry in the samples of multiple meningiomas and solitary meningiomas. Results:Female predominance was obvious in cases of multiple meningiomas. The tumors had wide distributions with a main location in brain convexity. The results of immunohistochemistry showed stronger expression of PR and similar expression of p53 and MIB-1 in samples of multiple meningiomas than those in solitary meningiomas. Conclusion:The diagnosis of multiple meningiomas mainly depends on radiological examination. The pathogenesis of multiple meningiomas is probably related to progesterone and its receptor, and it is most likely monoclonal origin.

Multiple Intracranial Meningiomas

Since introduction of magnetic resonance imaging(MRI), six cases of multiple intracranial meningiomas without signs of neurofibromatosis were found among the forty eight cases of meningiomas. The incidence of multiple intracranial meningiomas in our series was 12.5% of all meningiomas. We analyzed six cases of multiple intracranial meningiomas that were evaluated by MRI. Two tumors were found in five patients, whereas the other one patient had more than ten tumors at different sites. The tendency of unihemispheric distribution was not seen and two cases had bilaterally located tumors and other two cases had tumors above and below the tentorium without tentorial involvement. Relatively high occurrence of meningioma in posterior fossa was observed. Half of the six cases had posterior fossa tumors and 6 tumors(28.6%) of the total 21 tumors were located in the posterior fossa. All the cases were female. Mean age on admission was 61.3 years, ranged from 44 to 77 years. All six patients were treated surgically and three of them underwent multiple staged operations. Histologically, of the 12 tumors removed, 5 were transitional, 4 were fibroblastic, 3 were meningothelial. The histological subtypes of tumors in each case were different in two cases, but identical in other three cases. The surgical results, although the follow-up periods(ranged 3 months to 2.5 years) were not long enough in some cases, were favorable.

Multiple Intracranial Meningiomas: Case Report

Meningioma is the third most common intracranial tumor and different from meningiomatosis and multiple meningiomas. Multiple meningiomas without the stigma of Von Recklinghausen's disease are rare. The incidence of multiple meningiomas has been reported in 1-8.9% of all intracranial meningiomas. Although the pathogenic factors related to the multiple meningiomas are unknown, various theories have been studied and reported. The authors report two cases with multiple meningiomas without evidence of the Von Recklinghausen's diseases treated successfully by staged operation. The clinical, radiological and histopathological features of these lesions are discussed.

A Case of Multiple Meningiomas: Case Report

The neurosurgical frequency of multiple intracranial meningioma is low. The authors report a case of multiple meningiomas of supratentorial region and posterior fossa. The patient was 57-year-old female and presented with severe headache and vomiting. Computerized tomography and magnetic resonance imaging revealed multiple meningiomas in right parasagittal region. right temporal region and posterior fossa. The patient was treated successfully by stage operation and all of these pathological types was meningotheliomatous meningioma.

Multiple Meningioma: Case Report

Despite of their frequent occurrence among the brain tumor, meningiomas are rarely seen as a multiple growth. Most authors report an incidence ranging from 1 to 3% of all meningioma prior to the introduction of computed tomography. After the CT has introduced, diagnostic problems involved with multiple meningiomas were resolved, and its reported incidence was arisen to 8~8.9% of all meningiomas. It may be difficult to differenciate multiple meningioma from the special varient(forme fruste) of von Recklinghausen's disease. Although the pathogenetic factors related to the multiple meningiomas are unknown, various theories of the etiology have been studied and reported. We report a patient with multiple meningioma without evidence of von Recklinghausen's diseases.

Multiple Meningiomas: A Case Report

Meningioma has been considered to be rare as multiple growths. More often than not, they are associated with neurofibromatosis, bilateral acoustic tumors and multiple angiomata. Less frequently multiple meningiomas may be present without these associated problems. Cushing and Eisenhardt called the former "meningiomatosis" and the latter multiple meningiomas. The incidence of multiple meningiomas has been reported 1-8.9% of all intracranial meningiomas. The availability of CT has increased the incidence of the diagnosis of multiple meningiomas by visualizing smaller meningiomas which would have remained undetected and it seems to be reasonable that some elderly patients with multiple lesions diagnosed by CT should be followed and not operated on. We report a patient with multiple meningiomas without evidence of von Recklinghausen's disease and explore its various theories of the etiology.

Multiple Meningiomas(A case Report)

Meningioma is third common intracranial tumor and different from meningiomatosis and multiple meningiomas. Multiple meningiomas without the stigma of Von Recklinghausen's disease are rare. The incidence of multiple meningiomas is higher in post CT era which reported about 8.9% by Lusins et al than reported previousely about 1-3%. The cause of multiplicity is unknown but the possible cause of the higher incidence and various theories of the etiology of multiple meningiomas are explored by literature review. We reported the rare case of multiple meningiomas, which diagnosed by CT scan and confirmed by operation and follow up checked in OPD.