ABSTRACT
Plexiform schwannoma is a rare variant of benign schwannoma characterized by a multinodular and plexiform growth pattern. Schwannomatosis is a recently recognized disorder, defined as multiple, pathologically-proven schwannoma without vestibular tumors, diagnostic of neurofibromatosis 2. Although plexiform schwannoma is usually solitary, multiple plexiform schwannomas do also occur as an isolated finding or in association with neurofibromatosis 2. We describe a 7-year-old girl who had multiple cutaneous plexiform schwannomas and neurologic deficits such as sensorineural hearing loss and amblyopia on her left side. Brain magnetic resonance imaging and ophthalmologic examination was negative for vestibular schwannoma and eye stigmata of neurofibromatosis 2. However, as there is a possibility that the patient may eventually develop additional cranial tumors such as meningiomas or vestibular schwannomas, we therefore recommend that she is periodically screened.
Subject(s)
Child , Female , Humans , Amblyopia , Brain , Christianity , Hearing Loss, Sensorineural , Magnetic Resonance Imaging , Meningioma , Neurilemmoma , Neurofibromatosis 2 , Neurologic Manifestations , Neuroma, AcousticABSTRACT
Minocycline is a semi-synthetic, broad-spectrum, antimicrobial agent that was first introduced into clinical practice in 1967. Its primary indication is for the treatment of acne vulgaris, where its success has been attributed to a combination of its bacteriostatic and anti-inflammatory activities. There has been recent interest in minocycline use in the treatment of various other chronic inflammatory and immune-mediated diseases such as Behcet's disease and recurrent apthous ulceration. A well-recognized side effect of minocycline treatment is pigmentation, which has been reported in multiple tissues including skin, nail beds, sclera, bone, the thyroid, and teeth. However, pigmentation of the tongue caused by minocycline is very rare. We report four cases of actual pigmented lesions on the tongue and finger nails due to minocycline therapy, followed by a discussion of minocycline-induced hyperpigmentation.