Chiffonnage... em direção ao sinthome: a voz além do muro / Chiffonnage... towards the sinthome: the voice beyond the wall / Chiffonnage ... vers le sinthome: la voix au-delà du mur / Chiffonnage ... hacia el sinthome: la voz, más allá del muro

Este texto tenta discutir o lugar da voz na noção de chiffonnage ─ que Lacan esboça no seminário 24 ─ como uma direção da cura, ou, mais precisamente, uma in(ter)venção em direção ao sinthome. Trata-se de pensar a chiffonnage como uma in(ter)venção clínica com a voz, quer dizer, uma in(ter)venção que opera sobre a fonação, sobre a voz que é, no corpo, um real pulsional do fato que há um dizer. A voz aqui está para além do muro da palavra, em que é necessário quebrar o muro, chiffonner a palavra para fazer um outro uso que aquele para o qual ela é feita. Nessa operatória, é necessário fazer uma torção da voz para inventar um significante novo, um significante que não teria, como o real, nenhuma espécie de sentido.

This article discusses the place of the voice in the notion of chiffonnage -which Lacan sketches in Seminar 24 - as a direction of healing or, more precisely, an intervention towards the sinthome. Chiffonnage is understood as a clinical intervention using the voice, i.e., an intervention that operates on phonation, on the voice that is, in the body, an actual instinct of the fact that there is a saying. The voice here lies beyond the wall of the word, it requires breaking the wall, chiffonner the word to make a different use of it than the original one. This operation requires twisting the voice to invent a new signifier free of any meaning, as opposed to the actual one.

Cet article cherche à discuter la place de la voix dans la notion de « chiffonnage ¼ - que Lacan va esquisser dans le Séminaire 24 - comme un élément de la direction de la cure ou, plus précisément, une intervention vers le sinthome. Il s´agit de penser le chiffonnage comme une intervention clinique avec la voix, c´est-à-dire, une intervention qu´on opère sur la phonation, sur cette voix qui est, dans le corps, un réel pulsionnel du fait qu´il y a un dire. La voix est au-delà du mur de la parole et il est nécessaire de casser le mur, de chiffonner la parole pour faire d'elle un autre usage que celui pour lequel elle a été faite. Pour y parvenir, il faut effectuer une torsion de la voix afin d'inventer un signifiant nouveau, un signifiant qui n´aurait, comme le réel, aucune espèce de sens.

Este texto intenta discutir el lugar de la voz en la noción de chiffonnage - noción esbozada por Lacan en su Seminario 24 - como elemento de la gestión de la cura o, más precisamente, como una intervención hacia el sinthome. Se trata de pensar en la noción de chiffonnage como una intervención clínica con la voz, es decir, una intervención que actúa sobre la fonación, sobre esta voz que es, en el cuerpo, una pulsión real del hecho de que hay un decir. Aquí, la voz supera el muro de la palabra, en que es necesario romper el muro, chiffonner la palabra para que cumpla otro uso diferente al uso para la cual fue hecha. En esta operación, es necesario hacer una torsión de la voz para inventar un nuevo significante, un significante que no tendría, como el real, ninguna especie de sentido.

Advances in the research of inhibitors of enzymes of bacterial peptidoglycan biosynthesis / 药学学报

In recent years, owing to the abuse of antibiotics, the widespread of resistant bacterial strains became a serious threat to public health. This status demands development of new antibacterial agents with novel mechanisms of action. The reason for the limited new antibacterials is the small number of effective therapeutic targets, which cannot meet the current needs for the multiple drug-resistant treatment. Screening for new targets is the key step in the development of novel antibacterial agents. Peptidoglycan is the main component of the cell wall of bacteria, which is essential for survival of pathogenic bacteria. Within the biochemical pathway for peptidoglycan biosynthes is the Murligases, described in this review as highly potential targets for the development of new classes of antibacterial agents. This review provides an in-depth insight into the recent developments in the field of inhibitors of the Mur enzymes (MurA-F). Moreover, the reasons for the lack of candidate inhibitors and the challenges to overcome the hurdles are also discussed.

Raman spectroscopy shows difference in drugs at ultrahigh dilution prepared with stepwise mechanical agitation

OBJECTIVE: The present study aims at deciphering the nature of the water structure of two ultrahigh diluted (UHD) homeopathic drugs by Laser Raman Spectroscopy. METHOD: Two homeopathic drugs Sulphur and Natrum mur in three UHD 30cH, 200cH and 1000cH were selected for the study. Raman spectra of the drugs and their medium (90% ethanol) were obtained in the wave number region of 2600-3800 cm-1. The intensity ratio at vibration frequencies between 3200 and 3420 (R1) and that between 3620 and 3420 (R2) was calculated for each UHD as well as the control. RESULTS: Raman spectra shows differences in intensities in different UHDs and their control in the stretching vibrations of CH and OH groups. The three UHDs of each drug show an inverse relationship with respect to the R1 values. However, for R2 the relationship of UHD for each drug is positive. CONCLUSION: R1 provides information about the relative number of OH groups with strong and weak hydrogen bonds. R2 suggests the relative number of OH groups with broken and weak hydrogen bonds. Judged from R1 values the lower is the rank of UHD, the stronger is the H-bond of the OH groups. In the light of R2 values, the higher is the UHD rank the more abundant is the free OH groups. So, hydrogen bond strength and free OH groups together make an effective UHD rank relating to Sulphur and Natrum mur.

Analysis of anti-E IgG combined with IgG + IgM anti-Mur for leading to the cross-match incompatibly / 国际检验医学杂志

Objective To perform the serological identification of anti‐E and anti‐Mur found in the detection before blood trans‐fusion and to analyze its clinical significance in blood transfusion .Methods The reaction pattern of serum with the antibody screen‐ing spectrum was detected by using the micro‐column gel method for identifying the antibody type and specificity .Results The 3 kinds of antibody anti‐E IgG combined with anti‐Mur IgG + IgM existed in the serum of 2 patients .Conclusion Anti‐E and anti‐Mur all are easier to lead to the hemolytic blood transfusion reaction .Selecting the suitable donor on the basis of the accurate anti‐body identification can provide guarantee for blood transfusion safety .