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1.
Korean Journal of Dermatology ; : 75-76, 2016.
Article in Korean | WPRIM | ID: wpr-22804

ABSTRACT

No abstract available.


Subject(s)
Acupuncture , Mycobacterium
2.
Korean Journal of Dermatology ; : 133-137, 2015.
Article in Korean | WPRIM | ID: wpr-196197

ABSTRACT

Mycobacterium massiliense is a new emerging pathogen within the M. chelonae-M. abscessus group that has been described recently. Mycobacterium massiliense usually causes pulmonary or skin and soft tissue infections in immunocompromised patients; however, cutaneous infections have also been reported in healthy individuals following surgical procedures or laparoscopic surgery. This potentially hazardous microorganism should not be overlooked because it often shows resistance to conventional antibiotics. A 25-year-old woman presented with erythematous nodules on her left leg, which was a liposuction site. A histopathological examination showed suppurative granulomas with mixed cellular infiltrations within the dermis and fat layer. Rod-shaped bacilli were detected within the clear spaces of the dermis using Ziehl-Neelsen stain. An acid-fast bacterial culture showed colony formation, and using the polymerase chain reaction-restriction fragment length polymorphism analytical method and the ERM gene, we identified M. massiliense. After surgical excision and the systemic administration of medication comprising clarithromycin and linezolid for 6 months, all of the cutaneous lesions improved and no new lesions occurred.


Subject(s)
Adult , Female , Humans , Anti-Bacterial Agents , Clarithromycin , Dermis , Granuloma , Immunocompromised Host , Laparoscopy , Leg , Lipectomy , Mycobacterium , Skin , Soft Tissue Infections , Linezolid
3.
Annals of Dermatology ; : 92-95, 2014.
Article in English | WPRIM | ID: wpr-48640

ABSTRACT

Mycobacterium massiliense which is recognized as a separate species from M. abscessus is little known regarding its clinical patterns and the response to treatment. We present a case of a localized cutaneous infection due to M. massiliense of the sole associated with acupuncture. M. massiliense was identified via polymerase chain reaction-hybridization analysis. We treated the patient with single-drug therapy consisting of clarithromycin for 4 months and the patient showed a significant response to this treatment.


Subject(s)
Humans , Acupuncture , Clarithromycin , Foot , Mycobacterium
4.
Article in English | IMSEAR | ID: sea-138697

ABSTRACT

We report a case of a patient suffering from multidrug-resistant pulmonary tuberculosis (MDR-PTB) who later developed an invasive infection of the respiratory tract with a rapidly growing non-tuberculous mycobacteria (NTM), recently identified as Mycobacterium massiliense, closely related to M. abscessus. To the best of our knowledge, this is the first case of M. massiliense infection being reported from India.


Subject(s)
Antitubercular Agents/pharmacology , Antitubercular Agents/therapeutic use , Drug Resistance, Microbial , Female , Humans , Middle Aged , Mycobacterium Infections, Nontuberculous/drug therapy , Mycobacterium Infections, Nontuberculous/microbiology , Mycobacterium tuberculosis/drug effects , Nontuberculous Mycobacteria/drug effects , Nontuberculous Mycobacteria/isolation & purification , Sputum/microbiology , Tuberculosis, Multidrug-Resistant/microbiology , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/microbiology
5.
Journal of Bacteriology and Virology ; : 17-28, 2012.
Article in Korean | WPRIM | ID: wpr-77063

ABSTRACT

Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) that cause a broad spectrum of infections in humans. In addition, the association of M. abscessus with the cause of community- and hospital-acquired infections has been recently reported. In fact, M. abscessus is known to be the most drug-resistant mycobacterium and naturally resistant to first-line anti-tuberculous drugs, resulting in the limited therapeutic options and a high failure rate of treatment response. Three closely related species; M. abscessus (sensu stricto), M. bolletii, and M. massiliense are currently identified however, consensus on the naming of M. abscessus-related species has not been made to date. We herein discuss the advanced understanding of the virulence potentials and pathophysiological features of M. abscessus to establish novel therapeutic strategies for M. abscessus infection.


Subject(s)
Humans , Consensus , Mycobacterium
6.
Korean Journal of Medicine ; : 243-248, 2012.
Article in Korean | WPRIM | ID: wpr-96835

ABSTRACT

Mycobacterium massiliense is an emerging pathogen that is increasingly reported as a causative agent occurring during medical procedures, at surgical sites, and intramuscularly [1]. Although previously classified as part of M. abscessus, M. massiliense has recently been identified as a new species of rapidly growing nontuberculous mycobacteria [1,3] via a comparative sequence analysis of rpoB and hsp65 [3,5]. However, the clinical manifestations of M. massiliense have not been well characterized. We report here in a case of recurrent pneumonia for 3 years that improved with antibiotic treatment for M. massiliense in a 37-year-old woman with Sjogren's syndrome. The patient showed a substantial response to treatment with a combination of antimicrobial therapies comprising clarithromycin and amikacin without cefoxitin for 6 months. This is the first report of pulmonary infection of M. massiliense with Sjogren's syndrome in Korea.


Subject(s)
Adult , Female , Humans , Amikacin , Cefoxitin , Clarithromycin , Korea , Mycobacterium , Nontuberculous Mycobacteria , Pneumonia , Sequence Analysis , Sjogren's Syndrome
7.
Annals of Dermatology ; : 114-118, 2010.
Article in English | WPRIM | ID: wpr-172919

ABSTRACT

Mycobacterium massiliense, an emerging pathogen that is increasingly reported as a causative agent in infections occurring during medical procedures, is difficult to be identified using conventional methods. Here we report the case of a cutaneous M. massiliense infection that was associated with repeated surgical procedures and that was identified via a comparative sequence analysis of rpoB and hsp65. The patient showed a substantial response to treatment with a combination of antimicrobial therapies consisting of clarithromycin, amikacin, and cefoxitin for 6 months.


Subject(s)
Humans , Amikacin , Cefoxitin , Clarithromycin , Mycobacterium , Sequence Analysis
8.
Tuberculosis and Respiratory Diseases ; : 39-42, 2010.
Article in English | WPRIM | ID: wpr-129612

ABSTRACT

Mycobacterium massiliense is newly identified rapid-growing nontuberculous mycobacterium, but there are no reports of this mycobacterium species being the cause of human illness. We describe one case of Mycobacterium massiliense infection presenting as antibiotic-resistant acute pneumonia that resulted in surgical treatment.


Subject(s)
Humans , Anti-Bacterial Agents , Mycobacterium , Nontuberculous Mycobacteria , Pneumonia
9.
Tuberculosis and Respiratory Diseases ; : 39-42, 2010.
Article in English | WPRIM | ID: wpr-129597

ABSTRACT

Mycobacterium massiliense is newly identified rapid-growing nontuberculous mycobacterium, but there are no reports of this mycobacterium species being the cause of human illness. We describe one case of Mycobacterium massiliense infection presenting as antibiotic-resistant acute pneumonia that resulted in surgical treatment.


Subject(s)
Humans , Anti-Bacterial Agents , Mycobacterium , Nontuberculous Mycobacteria , Pneumonia
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