Clinical analysis of 10 children with cardiac thrombus associated with Mycoplasma pneumoniae infection / 中华实用儿科临床杂志

Objective:To explore the case characteristics, treatment and prevention measures of cardiac thrombus in children caused by Mycoplasma pneumoniae infection, so as to improve the clinicians′ understanding of the disease.Methods:The clinical data of 10 children with cardiac thrombus caused by Mycoplasma pneumoniae infection treated in Department of Respiratory Intervention, Jinan Children′s Hospital from November 2015 to January 2020 were retrospectively analyzed, including datum of cases, laboratory results, imaging data and follow-up results.Results:A total of 10 children (7 males and 3 females) were included with the median age of 6.5 years old, and all had fever for more than 1 week.The plasma D-dimer (D-D) of 9 children was significantly increased, and the C-reactive protein (CRP) of 6 children was increased.After anti-infection treatment, the absorption of pneumonia with atelectasis was better than before.The embolus disappeared after operation in 1 case, and the remaining 9 cases received anticoagulant therapy, among which 7 cases received Heparin anticoagulant therapy alone: cardiac embolus disappeared during hospitalization in 2 cases, disappeared after 2 weeks of oral administration of Dipyridamole outside the hospital in 1 case, and the other 4 cases received Heparin anticoagulant therapy alone during hospitalization with poor effect, embolus disappeared in 2 cases 4 and 5 months after discharge respectively, and 2 cases were not reexamined due to personal reasons; the embolus disappeared 2 months after discharge in 2 cases who were changed to low-molecular weight Heparin + Warfarin anticoagulant therapy after failing to respond to Heparin anticoagulant therapy.All the 10 cases showed no symptoms of tachypnea or chest pain during telephone follow-up.Conclusions:Children with long fever time and significantly elevated CRP and D-D are more likely to form thrombus.Anticoagulant therapy is effective after thrombosis, and surgical thrombectomy can be performed in children who have failed to respond to anticoagulant therapy or worry about complications caused by dropped embolus.

Significance and progress in laboratory diagnosis of Mycoplasma pneumoniae pneumonia / 中华实用儿科临床杂志

Mycoplasma pneumoniae pneumonia (MPP) is a clinical common respiratory tract infectious di-sease.In recent years, the number of children with severe and refractory MPP has increased significantly.Clinical symptoms of MPP are usually atypical, and some MPP cases are accompanied with extrapulmonary complications.In addition, imaging features of MPP also lack specificity.The diagnosis of MPP, as a result, often relies on laboratory examinations.The present study demonstrated the clinical significance in laboratory diagnosis of Mycoplasma pneumoniae (MP) infection, and the method to distinguish present infection, previous infection or carriers in healthy children′s respiratory tract.Moreover, the method to determine macrolide-resistant MP was also described in this study.This study aims to improve the understanding, diagnosis and treatment of MP infection.

Two kinds of test methods of Mycoplasma pneumoniae infection in children / 中国生化药物杂志

Objective To investigate two methods for the detection of Mycoplasma pneumoniae infection in children. Methods The choice of the January 2015-2017 year in January in our hospital 60 cases of Mycoplasma pneumoniae infection in children as the research object, underwent rapid serological tests (control group), rapid detection of microbial culture (observation group), the detailed records of the two group with the experimental data,and the data for comparative analysis and discuss the diagnostic value of two test methods of Mycoplasma pneumoniae infection in children. Results The positive rate of the observation group was higher than that of the control group, and the positive rate of the children in the age group of 4-8 was higher than that of other age groups, the difference was statistically significant (P<0.05). Conclusion Children with Mycoplasma pneumoniae infection have a higher positive rate of rapid detection of microorganisms, especially in children of 4-8 years of age.It is worthy of wide clinical application.

Clinical Observation of Azithromycin Combined with Reduning Injection in the Treatment of Children with Mycoplasma Pneumoniae Infection / 中国药房

OBJECTIVE:To observe the clinical efficacy and safety of azithromycin combined with Reduning injection in the treatment of children with mycoplasma pneumoniae infection. METHODS:80 children with mycoplasma pneumoniae infection were randomly divided into control group and research group. All the children were given routine treatment,including oxygen inha-lation,defervescence,nutritional support,reducing sputum and relieving asthma,etc. Based on it,children in control group were orally treated by Azithromycin enteric coated tablets 10 mg/kg,once a day. Children in research group were treated by Reduning in-jection 10 ml and 5% glucose injection 100 ml by intravenous infusion,once a day,based on the treatment in control group. The course of both was 14 d. The clinical data was observed,including the clinical efficacy,interleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α(TNF-α)and the incidence of adverse reactions(ADR)before and after treatment. RESULTS:The total effective rate in research group was significantly higher than control group,with significant difference(P0.05). CONCLUSIONS:Based on the routine treatment,azithromycin combined with Reduning injection has more obvious efficacy than only azithromycin in the treatment of children with mycoplasma pneumoniae infection with similar safety.

Investigation of Correlation between Gene Polymorphism of Apolipoprotein E and Mycoplasma Pneumoniae Infection in Children / 现代检验医学杂志

Objective To study the relationship between gene polymorphism of apolipoprotein E (apolipoproteinE,ApoE)of peripheral blood and Mycoplasma pneumoniae infection in children.Methods Collected 236 cases serum of inpatient and outpatient screening in children with Mycoplasma pneumoniae infection and healthy children between March 2011 and March 2014 in the First Affiliated Hospital of Xi’an Medical University and Xi’an Children’s Hospital,at the age of 3~8 years old,divided into two groups:110 cases of control group and 126 cases of Mycoplasma pneumoniae infection in chil-dren.Used multiple allele-specific PCR (multi-AS PCR)to detect gene polymorphism of ApoE in each group.Results ApoE gene was polymorphic and 6 genotypes:3 homozygous (ε2/2,ε3/3,ε4/4)and 3 heterozygote (ε3/2,ε3/4,ε4/2).Theε3/2 had four bands,ε3/3,ε3/4 and 4/2 had three bands,ε2/2 andε4/4 had two bands.ε3/3 of ApoE genotype distribution in two groups was the most common,control group was 66.7%,infection group was 46.4%.Allele frequencies ofε3 and genotype frequencies ofε3/3 inMycoplasmapneumoniae infection of children were lower than those in control group (P<0.05).But allele frequencies ofε4 and genotype frequency ofε4/4 in Mycoplasma pneumoniae infection of children were increased, which were compared with those in control group (P<0.05).Conclusion There were an association between ApoE gene polymorphism and the incidence of Mycoplasma pneumoniae infection in children.Allelesε3 seems to be a protective factor and allelesε4 may contribute to the development of Mycoplasma pneumoniae infection of children.

Analysis of variation in coagulation function of 36 children with Mycoplasma pneumoniae / 中华急诊医学杂志

Objective To study the effect of Mycoplasma pneumoniae infection on the coagulation system in children and to clarify its mechanism in order to guide the therapeutic strategy for Mycoplasma pneumoniae infection in clinical practice.Methods A prospective and case control study was carried out in 36 children with Mycoplasma pneumoniae infection in Weifang People ' s Hospital from January through December in 2011.The 36 patients were divided into two groups according to the MP-IgM plasma titers,namely low-titer group with MP-IgM 1 ∶ 80-1 ∶ 160 (n =17) and high-titer group with MP-IgM 1 ∶ 320-1 ∶1280 (n =19).The subjects of control group (n =20) were recruited from healthy children as they took routine physical examination during the same period.Six indexes related to the coagulation function as well as D-dimer in plasma were determined.All data were analyzed by using SPSS 15.0 software.Results The levels of fibrinogen (FIB) and D-dimer in the low-titer group and high-titer group were significantly higher than those in the control group (P ＜ 0.05).The prothrombin (PT) and activated partial thromboplastin time (APTT) in the high-titer group were significantly shorter than those in the control group respectively (P ＜ 0.05).Conclusions Mycoplasma pneumoniae infection in children gives rise to the potential for activating the extrinsic and intrinsic coagulation system,promoting thrombosis and in turn inducing ischemic stroke in serious cases.

Bullous Erythema Multiforme and Stevens-Johnson Syndrome Caused by Mycoplasma pneumoniae Infection / 대한피부과학회지

In adults, bullous erythema multiforme is most often caused by herpes simplex virus infection, while Stevens-Johnson syndrome is most often associated with drug hypersensitivity. Mycoplasma pneumoniae infection is highly known to be a cause of bullous erythema multiforme and Stevens-Johnson syndrome in children and young adults. To our knowledge, there are only a few reports of bullous erythema multiforme or Stevens-Johnson syndrome induced by M. pneumoniae infection in the Korean literature. We encountered two cases of female children diagnosed as having bullous erythema multiforme associated with M. pneumoniae infection. We also describe an unusual case of Stevens-Johnson syndrome associated with M. pneumoniae infection in a 65-year-old woman.

A Case of Bilateral Spontaneous Tension Pneumothorax Associated with Mycoplasma pneumoniae Infection

Mycoplasma pneumoniae(M. pneumoniae) is the leading cause of pneumonia in school-age children and young adults. The clinical courses are usually mild but recently, severe cases were reported such as lung abscess, Swyer-James syndrome and adult respiratory distress syndrome. Spontaneous pneumothorax associated with M. pneumoniae infection is rare. Carlisle reported a 6-year-old patient with bilateral spontaneous pneumothorax associated with M. pneumoniae infection and Koura also reported a 18-year-old girl with repeated. M. pneumoniae pneumonia with recurrent pneumothorax. We experienced bilateral spontaneous tension pneumothorax and subcutaneous emphysema associated with M. pneumoniae infection in a 6-year-old boy who presented with dyspnea, chest pain, and neck swelling. We reported it as the first case in Korea.

Neurologic Complications Associated with Mycoplasma pneumoniae Infection

PURPOSE: Mycoplasma pneumoniae is known to be a common respiratory pathogen in children and cause neurologic complications in some patients. The clinical spectrum of the neurologic complications is wide, ranging from mild meningeal signs to severe neurologic symptoms with poor outcomes. The overall mortality in patients with neurologic complications has been approximated upto 10% and significant residual deficits could develop in about one third of the patients. This study was done to recognize the neurologic complications associated with M. pneumoniae and possibly to improve therapy and outcome. METHODS: We reviewed retrospectively the medical records of 8 patients with neurologic complications associated with M. pneumoniae infection in the department of Pediatrics, Asan Medical Center, during the period of 6 months from October,1993 to March, 1994. And we compared these cases with total 165 patients diagnosed as M. pneumoniae infection during the same period. RESULTS: 1) Neurologic complications were seen in 8 children among 165 patients with M. pneumoniae infection. 2) Among 8 patients, 4 patients were diagnosed as meningitis, 2 patients as Guillain-Barr syndrome, and 2 patients as ADEM. 3) 4 patients with meningitis were treated by erythromycin and 2 Guillain-Barr syndrome patients by IV gamma globulin and plasmapheresis, and 2 ADEM patients by methylprednisone pulse therapy and supportive therapy, respectively. 4) All patients improved without any neurological sequelae. CONCLUSIONS: Although M. pneumoniae is a common and usually self-limited pathogen in children, various neurologic complications can occur in a small proportion of patients. Therefore, M. pnuemoniae is to be considered as one of the etiologic agents of neurologic diseases in children.

A Case of Cerebral Infarction Associated with Mycoplasma pneumoniae Infection

Mycoplasma pneumoniae has been shown to be of etiologic importance in cases of upper-and lower-respiratory tract infections, especially in children and young adults. It may cause a variety of extrapulmonary manifestations in multiple organ systems, most commonly the central nervous system. The extrapulmonary syndromes include meningitis, cerebral infarction, acute transverse myelitis, psychosis, cerebellar ataxia, Guillain-Barr syndrome and Reye syndrome. Cerebral infarction as a complication of mycoplasma infection in children has been rarely reported. We report the first documented case in Korea of cerebral infarction preceded by M. pneumoniae pneumonia in a 7-year-old boy, with a brief review of literatures.

Relationship between Cough Variant Asthma and Mycoplasma Pneumoniae Infections / 实用儿科临床杂志

Objective To explore the relationship between cough variant asthma (CVA) and mycoplasma pneumoniae (MP) infection.Methods Fifty children with CVA were chosen as the experimental group at random,and 50 children with acute upper respiratory infection,who went to the hospital in the same time and with similar age,were chosen as control group.The MP-IgM of children in both groups were tested by the granule agglutinating method.Results Significant difference (? 2=9.013 P