ABSTRACT
Myositis ossificans progressiva (MOP) is a rare, slow progressive autosomal dominant disorder that principally affects children under the age 10 years. It is characterized by progressive fibroblastic proliferation, and subsequent calcification and ossification of subcutaneous fat, muscles, tendons, aponeuroses and ligaments. The disorder is often associated with symmetrical malformations of the digits, especially microdactyly or adactyly of the thumbs and great toes. The disease usually leads to extensive immobility and eventual disability. We experienced a case of MOP in a 2-year-old male child who showed multiple tender nodules on the left occipital, superior and inferior scapular, mid-back and upper buttock area and digital malformations and was treated with etidronate disodium. A brief review of related literatures is also presented.
Subject(s)
Child , Child, Preschool , Humans , Male , Buttocks , Etidronic Acid , Fibroblasts , Ligaments , Muscles , Myositis Ossificans , Myositis , Subcutaneous Fat , Tendons , Thumb , ToesABSTRACT
Myositis ossificans progressiva, a rare autosomal dominant disorder, is characterized by progressive heterotopic ossification of muscle and connective tissue associated with pain and disability. I have experienced a 15-year-old woman with multiple contracture and deformity in both lower extremities. Clinical features and laboratory findings including electrodiagnostic findings were compatible with myositis ossificans progressiva. I report this case with the review of literature.