The Effectiveness of Myprodol(R) on the Post-tonsillectomy Pain Control and Time to Return to Normal Daily Activities / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Pain is one of most troublesome discomfort after tonsillectomy. Although various analgesics have been administrated for pain control, it has not been effectively controlled until now. This study was performed to evaluate the effectiveness of Myprodol(R) codein combination analgesics, on the pain control and time to return to normal daily activities. SUBJECTS AND METHOD: Ninety adult patients undergoing tonsillectomy were included in this study. Patients were randomly divided into a Myprodol(R) group (n=30), a NSAID group (n=30) and a codeine group (n=30). They received Myprodol(R) NSAID and codeine, respectively, from the 3rd to 14th postoperative days. On the 1st, 7th and 14th postoperative days, which consisted of rising, breakfast, lunch and supper time, we assessed pain intensity by visual analogue scale. And on the 21st postoperative day, we investigated time to return to normal daily activities and adverse effects of analgesics. RESULTS: When pain intensity on the 1st postoperative day was compared, there was no significant difference among 3 groups. On the 7th postoperative day, the Myprodol(R) group showed significant pain decrease compared with the codeine group but did not with the NSAID group. On the 14th postoperative day, the Myprodol(R) group showed significant pain decrease compared with both NSAID and codeine groups. The Myprodol(R) group also showed shortened recovery time compared with the others and there was no significant adverse effects in any of the groups. CONCLUSION: We find that Myprodol(R) is an effective and safe oral analgesics for pain control and shortens time to return to normal daily activities.

Pain Control Effects of Myprodol(R) after Periodontal Surgery and Dental Implant Surgery / 대한치주과학회지

Although various analgesics have been administrated for postoperative pain control, postoperative pain has not been adequately controlled . The purpose of this study was to evaluate the effects and patient's satisfaction of Myprodol(R)(combination analgesics with codeine, ibuprofen, paracetamol) compared to Acetamionphen and placebo drug after periodontal surgery and dental implant surgery. We studied 98 cases of outpatients which were composed of 67 cases of flap operation(which separated to 3 groups: Placebo group(n=25), Myprodol(R) group(n=22), Acetaminophen group(n=20)) and 21 cases of dental implant surgery(which separated to 3 groups : Placebo group(n=10), Myprodol(R) group(n=12), Acetaminophen group(n=9)). We evaluated the postoperative pain(Pain 1), Pain after first drug administraion(Pain 2), the degrees of pain reduction(pain 3), patient's satisfaction for drug, and side-effects. We obtained following results; 1. In Pain 1, making a comparison among groups, there was no significant difference in both cases of flap operation-group and dental implant surgery-group 2. In Pain 2, establishing a comparison among groups, there was no significant difference in flap operationgroup, but significant difference was seen between placebo group and Myprodol(R) group in cases of dental implant surgery group(P<0.05). 3. In Pain 3, making a comparison among groups, Myprodol(R) group showed significant differences compared to placebo group and Acetaminophen group in both cases of flap operation group and dental implant surgery group(P<0.05). 4. In patient's satisfactory score, making a comparison among groups, there were significant differences between placebo group and Myprodol(R) group in cases of flap operation group and between Myprodol(R) group and Acetaminophen group in cases of dental implant surgery group(P<0.05). 5. Making a comparison in side-dffect, no significant differrence was seen. Our conclusion is that Myprodol(R) is a effective oral analgesics to the patients who underwent periodontal surgery or implant surgery for it's synergism among three dugs.