Bibliometric and bioinformatics analysis of genetic literature on susceptibility to noise induced hearing loss / 中华劳动卫生职业病杂志

Objective: To summarize and analyse of literature on the susceptibility genes of noise induced hearing loss (NIHL) , and the key genes were screened and obtained by bioinformatics method, so as to provide reference for the prevention research of NIHL. Methods: In September 2021, Based on CNKI, NCBI Pubmed database and Web of Science database, this paper conducted bibliometric analysis and bioinformatics analysis on the genetic literature related to the susceptibility to noise-induced hearing loss from 1999 to 2020. Endnote X9 software and the WPS office software were used for bibliometric analysis, and online software STRING and Cytoscape software were used for bioinformatics analysis. Results: A total of 131 literatures were included in the study, involving 40 genes in total. Bibliometric analysis shows that 131 papers which included 36 Chinese articles and 95 English articles were published in 63 biomedical journals; the highest number of published articles was 19 in 2020. Bioinformatics analysis suggests that GAPDH、SOD2、SOD1、CAT、CASP3、IL6 and other genes play a key role in the interaction network. The involved pathways mainly include MAP2K and MAPK activations, PTEN regulation, P53-depardent G1 DNA damage response, signaoling by BRAF and RAF fusions and soon. Conclusion: The study of noise induced hearing loss involves multi gene biological information, and bioinformatics analysis is helpful to predict the occurrence and development of noise induced hearing loss.

Task Analysis On Maintenance Worker (Rail Grinder) Of Light Rail Transit (LRT)

@#Rail maintenance routines are necessary to enable the all rail operations to achieve its aim in maintaining a safe and efficient operation. The maintenance tasks expose the workers to vibration and noise, as they handle specialized machineries and heavy self-propelled vehicles. Exposure of noise above the permissible exposure limit and over the daily allowable duration may cause noise-induce hearing loss (NIHL). Investigation on the type of task that has high noise level exposure on the maintenance workers was conducted to justify the needs to further detailed of this study. This paper will describe the task analysis on maintenance workers and to identify possible tasks with exposure to high level of noise. It scopes down to grinding crew of the maintenance department of light rail transit. Methods used were real-time sound measurement using a sound level meter, observation and interviews. Then, data were analysed to understand the situation of exposure of noise during rail maintenance. An ergonomic risk assessment was also conducted by adoption of the latest guideline on Ergonomic Risk Assessment (ERA) at Workplace Guidelines recommended by Department of Occupational Safety and Health (DOSH), Malaysia. A hierarchical task analysis (HTA) was generated on the task of the maintenance worker, focusing on rail grinding crew. The newly generated HTA had allowed better understanding about the nature of work and the task conducted by a rail grinder during the work shifts. Tasks involving high noise level was identified. Data recorded shows that the noise level for the blowing activity was relatively high and exceeded the permissible exposure limit of 90dBA. The exposure level was currently controlled by practicing the usage of hearing protection equipment (HPE) and by controlling exposure time in accordance to recommendations of the Factory and Machinery Act (FMA). Thus, it had confirmed that maintenance workers were exposed to high noise levels when performing their daily task. Further studies are needed to investigate the relationship between the duration of exposure and noise-induce hearing loss (NIHL) with consideration of the lifestyles of the maintenance workers.

The Hearing Level among the Workers of Cement Industry

Objective: In this study our main goal is to evaluate thehearing level among the workers of cement industry.Methodology: This Cross-sectional observational study wasconducted at Department of Physiology, Chittagong MedicalCollege, Chittagong and Heidelbargh Cement Bangladesh Ltd.East Halishar, Chittagong, One year (January 2011 toDecember 2011). Where total number of 800 (Eight hundred)subjects were included. During the study, all subjects wereselected purposively on the basis of noise exposure studyprocedure. After selection and proper counseling, the aim,objective and procedure of the study was explained in detailsto all subjects, in the cement industry.Results: During the study highest frequency of hearing losswas found in 30-40 years age group. Most of the patientsworked in production area for 5-10 years. most of the patientsexposed to 70-80dB, 41.4%.51.6% patients exposed >8 hoursdaily and 65.5% patients exposed 42-48 hours weekly.Conclusion: From our study we can conclude that the studyclearly demonstrated that noise is a serious health hazard inthe cement industry. Hearing threshold for the subjectsexposed to noise increase with the progress of age andduration of employment. Further study is needed for betteroutcome.

Can FMA (Noise) 1989 Prevent Occupational NoiseInduced Hearing Loss? An Evaluation using Fault Tree Analysis

@#Introduction: Factory and Machinery Act (Noise Exposure) Regulation 1989 (FMA [Noise] 1989) has been implemented in Malaysia for nearly 30 years, but noise-induced hearing loss (NIHL) cases is still rising. Fault tree analysis is a top-down approach to analyzing incidences of 'failures', starting with establishing the single top event that will eventually cause NIHL, followed by identification of the contributing factors to the top event which are the immediate or basic events. Through its visual, structural and deductive approach; FTA is able to depict the temporal sequence of events and their interactions in a formal and logical hierarchy. Materials and Methods: Employees with permanent standard threshold shifts (PSTS) underwent further assessment confirming the presence of NIHL. A single common fault tree was constructed based on six cases of PSTS. The top event is the PSTS. Intermediate and basic events were identified and mapped with relevance to the provisions in the FMA (noise) 1989 indicating how failed control measures have resulted in the PSTS cases. Results: The constructed fault tree with its branches illustrated how breach or noncompliance of FMA (Noise) 1989 resulted in the eventual top event (NIHL). Conclusion: FTA provides a standardized perspective of errors within the system in preventing NIHL.

THE EFFECT OF NOISE POLLUTION ON HEARING IN MARBLE FACTORY WORKERS OF AJMER, RAJASTHAN: A CASE STUDY

Introduction: The noise pollution is defined as the unwanted sound which is released into the environment. Noise induced hearing loss in an increasingly prevalent disorder that result from exposure to high intensity sound, especially over a long period of time. Materials & Methods: The present study has been conducted in the Department of Physiology and E.N.T. in a group of 60 subjects with 30 marble factory workers and 30 normal individuals. Results: Audiometric values were consistently lower in Normal than in marble factory workers. The differences were statistically significant among both sexes and that too for the parameters of Right and Left ear. Discussion and conclusion: In this study mild hearing loss was 20%, moderate hearing loss was 16.67%, moderately severe hearing loss was 36.67% and severe hearing loss 26.66%.This study also concludes that the presence of impact noise is more Hz to hearing irrespective of the duration of exposure but in workers exposed to continuous noise, the duration of exposure had a more prominent effect on the hearing loss.

Incidência de perda auditiva induzida por ruído ocupacional entre trabalhadores de uma mineradora e pelotizadora de minério de ferro / Incidence of hearing loss induced by occupational noise among workers in a company engaged in iron ore mining and pelletizing

INTRODUÇÃO: Em consequência da modernização tecnológica e industrial, surgiram novos fatores que originaram estudos específicos e direcionados sobre os possíveis efeitos nocivos desta evolução no trabalhador. Dentre estes, está o ruído, agente físico que pode causar danos ao organismo humano com efeitos de curto e médio prazo. O ruído, ao atuar sobre o trabalhador pode alterar processos internos do organismo, com consequências fisiológicas e emocionais. A diminuição gradual da acuidade auditiva decorrente da exposição continuada a níveis elevados de pressão sonora é denominada perda auditiva induzida pelo ruído (PAIR), segundo o Comitê Nacional de Ruído e Conservação Auditiva. A PAIR é caracterizada por perda neurossensorial, irreversível, quase sempre bilateral e simétrica, não ultrapassando 40dB(NA) nas frequências graves e 75dB(NA) nas frequências agudas; manifesta-se, primeiramente, em 6kHz, 4kHz e/ou 3kHz, progredindo lentamente às frequências de 8kHz, 2kHz, 1kHz, 500Hz e 250Hz. (MTE, Portaria 19, 1998). Entre os fatores que influenciam no desencadeamento da PAIR, destacam-se as características físicas do ruído (tipo, espectro e intensidade da pressão sonora), o tempo de exposição e a suscetibilidade individual. A PAIR está entre as doenças do trabalho de maior prevalência, com agravante de tratar-se de uma doença irreversível. Acomete com mais frequência o setor industrial. Este estudo avalia a incidência de perda auditiva por ruído e a existência de uma associação positiva entre estes diagnósticos e a exposição a diferentes níveis de pressão sonora em trabalhadores de duas unidades de uma mineradora e pelotizadora de minério de ferro. MÉTODOS: Estudo de coorte histórica com 1.069 trabalhadores divididos em dois grupos, tendo como referência os níveis de pressão sonora aos quais estavam expostos (menor ou igual a 88 dB e acima de 88 dB). A avaliação da audição foi realizada por análise dos resultados das audiometrias realizadas nos exames admissionais...

INTRODUCTION: As a result of technological and industrial modernization new factors have arisen which led to specific studies have focused on the possible harmful effects of this evolution on the worker. Among these factors is noise, a physical agent which can harm the human body with short and medium term effects. Noise can alter internal body processes, with physiological and emotional consequences. The gradual reduction of hearing acuity resulting from a continued exposure to high levels of noise pressure is called noise-induced hearing loss (NIHL), according to the National Committee of Noise and Hearing Conservation. NIHL is characterized by a permanent sensorioneural impairment, almost always bilateral and symmetrical, not exceeding 40dB (NA) at lower frequencies and 75dB (NA) at higher frequencies. It first manifests at 6kHz, 4kHz and/or 3kHz, slowly progressing to the frequencies of 8kHz, 2kHz, 1kHz, 500Hz and 250Hz. (MTE, Ruling 19, 1998). Among the factors which trigger NIHL are the physical characteristics of the noise (type, spectrum and intensity of sound pressure), duration of exposure, and individual susceptibility. NIHL is among the most common occupational diseases, with the aggravating aspect of being irreversible. It is most often found in the industrial sector. This study will evaluate the incidence of noise-induced hearing loss and the existence of a positive association between these diagnoses and the exposure to different levels of sound pressure in workers at two operational units of a iron ore mining and pelletizing organization. METHODS: historical cohort study with 1069 workers, divided in two groups, using as baseline the sound pressure levels to which they were exposed (less than or equal to 88 dB and above 88 dB). The hearing assessment was carried out by means of an analysis of the results of the audiometry exam upon induction and at regular intervals, as recorded in the medical history of the individual...

Exposição ocupacional ao ruído em odontólogos do Paraná: percepções e efeitos auditivos / Occupational exposition to noise in dentists of State Paraná: perception and effects on hearing

Introdução: Níveis de pressão sonora intensos podem ser encontrados no ambiente de trabalho do odontólogo devido aos equipamentos utilizados. Esses níveis podem representar um risco à sua saúde. Objetivo: examinar os prováveis efeitos da exposição ocupacional ao ruído na audição de odontólogos, a percepção e o conhecimento dos mesmos acerca dos malefícios da exposição ao ruído e das possibilidades de prevenção. Método: trata-se de um estudo transversal (ou seccional), que avaliou a audição de 219 odontólogos (56,44% mulheres e 43,55% homens); estes também responderam a um questionário para coletar dados relativos à exposição ocupacional ao ruído. Resultado: prevalência de alterações auditivas de 32,51% nos 163 odontólogos incluídos na pesquisa; a ocorrência de alterações auditivas aumentou com a idade e os anos de serviço; com os anos de serviço, aumenta a jornada de trabalho, infuenciando na audição; o ruído no trabalho foi percebido como médio (49,07%); 96,9% conhecem os efeitos do ruído e 3,06% usam protetores auriculares. Concluiu-se que os odontólogos deste estudo apresentam alterações auditivas sugestivas de terem sido induzidas por ruído (razão de prevalência = 1,79 95% IC 0,09-4,44), quando a jornada de trabalho for igual ou superior a oito horas.

Introduction: intense sound pressure levels are found in the work environment of dentists, because of the equipment used. Such levels can represent a health risk. Aim: to examine the effects of occupational noise exposure on dentists' hearing, the beliefs and knowledge they have on noise exposure effects and preventive measures. Method: in this transversal (or cross-sectional) study 163 dentists (56.44 % female and 43.55% males) underwent hearing testing and an interview. Result: the prevalence of hearing loss among participants was of 32.51%; as age and duration of exposure (in years) increased there was an increase in hearing loss; as duration of exposure (in years) increased, the length of their work shift also increased; noise in the workplace was perceived as moderate by 49.07 % of the participants; 96.9% of the participants knew the effects of noise and 3.06% use hearing protector devices. We concluded that dentists in this study have hearing loss suggested by noise-induced (prevalence ratio = 1.79 95% CI 0.09-4.44). The highest prevalence of hearing loss was associated to work shift equal or longer than 8 hours.

The Effect of Working Noise Exposure and Military Background on the Hearing Threshold / 예방의학회지

OBJECTIVES: Impaired hearing is a prevalent occupational hazard, not only in industry, but also in the armed forces. In military life, noise has unusual characteristics, and constitutes a serious hazard to hearing. The aim of this study was to analyze the hearing threshold data in order to compare the hearing loss among shipyard workers, representing different workers, and a military service background. METHODS: A cross-sectional audiological survey, combined with a questionnaire study, was conducted on a stratified random sample of 440 shipyard workers, with long-term exposure to noise. The employees were divided into four groups, according to their working and military service backgrounds, in relation to their exposure to noise. RESULTS: As expected, the working and military noise exposure group (Group I) had significantly poorer hearing than the other groups. The high frequencies (2-8 kHz) showed the greatest difference in terms of poorer hearing in both ears. The prevalence of noise-induced hearing loss (NIHL) was highest in Group I. A logistic regression analysis was applied to determine the dependence of the NIHL in relation to age, smoking, drinking, working duration, ear protection, past history of ear diseases, and working and military service backgrounds, on the noise exposure. The important factors found to be related to the NIHL, in relation to noise exposure were: age, work duration, and working and military service backgrounds. The adjusted odds ratio estimates for NIHL in the right ear were 4.5 times greater (95% CI 1.7-11.6) for the military noise exposed group, and 7.9 times greater (95% CI 2.0-31.3) for the working noise exposed group than in the controls. The hearing thresholds at the pure-tone average and 4 kHz were significantly increased with age and work duration with both the working and military service backgrounds. CONCLUSIONS: From these results, specific preventive programs were planned, which should be assessed by epidemiological surveillance of the military noise exposed population.

Atypical Noise-induced Hearing Loss As a Workers'Impairment Criteria / 대한산업의학회지

OBJECTIVES: The problem of noise-induced hearing loss (NIHL) was objectively and systematically investigated by diagnosing three workers who complained of tinnitus and hearing disturbance. METHODS: Atypical hearing loss is diagnosed as a work-related disease by using general medical methods, such as environmental survey, neurological examination, otoscopy, pure-tone audiometry, speech audiometry, otoacoustic emissions (OAE), auditory-evoked potentials, and interview on the history of past disease, family and occupation. RESULTS: Three results were found according to the work-related hearing loss as follows; (1) hearing loss that is caused by exposure to continuous noise of less than 85 dB(A) or impact noise of greater than 135 dB peak, (2) mixed hearing loss that has progressed due to noise with past otitis media, and (3) atypical hearing loss that showed remarkable differences between air and bone conduction due to tinnitus. CONCLUSIONS: The criteria for work-related hearing loss should be carefully investigated by considering exposure to impact noise, the effect of continuous noise on mixed hearing loss patients, and the hearing loss caused by tinnitus.

Noise Induced Hearing Loss of 3 military workers that satisfied guidelines of occupational disease in Korean Occupational Safety & Health Act

Noise induced hearing loss (NIHL) is the most common occupational disease in Korea. However, there have not been reported NIHL in military workers that satisfied the decision guidelines of Korean Occupational Safety & Health Act. It is well known that aircraft maintenance workers expose to intensive noise. We found 3 military aircraft maintenance workers with NIHL that satisfied the decision guidelines of occupational disease in Korean Occupational Safety & Health Act. They were all in the base maintenance department and have work durations over 20 years. We hope these cases were sentinel events that activate the military occupational health management system.

Evaluation of Puretone Threshold Using Periodic Health Examination Data on Noise-exposed Workers in Korea / 예방의학회지

OBJECTIVES: This study was carried out to evaluate hearing impairment judgement and to investigate the differences in various diagnostic criteria for noise-induced hearing loss (NIHL) among workers who required for close observation (C). METHODS: Out of 731,029 workers who had taken the specific periodic health examination in 1994, we used the audiometric data on 37,999 workers (C) eliminating the employees who had previous otologic problems. Many investigators have being using different criteria for the evaluation of hearing impairment. In this study, we used the criteria of early (1989-1994), current, compensation for NIHL in Korea, 2-, 3-, 4-divided classification and hearing loss at 4,000 Hz and compared the evaluation results. RESULTS: The prevalences of C and workers who had occupational disease (D1) diagnosed for NIHL were 11.1 % and 0.44 %. There were significant difference in the prevalences of C and D1 depending on different province of Korea. Pure tone averages (PTAs) were not appropriately applied in their evaluation. 97% of workers whom we studied on were below the level of mild hearing loss judged by ISO standard. However, there were wide variations in the prevalence rate of mild hearing loss by diagnostic criteria. Thus, there were different judgements in determining the degree of NIHL depending on which diagnostic criteria were utilized. PTAs were found 20.54 (Rt) and 20.74 (Lt) when the method of 3-divided classification was applied for audiometric data. The degree of hearing impairment of the left ear was more severe than that of right ear. The prevalence of normal hearing threshold below 20 dB was 75.4% and the range of difference in both ear was below 10 dB. Right sided hearing threshold levels were 21.08 dB (500 Hz), 18.44 dB (1,000 Hz), 22.09 (2,000 Hz) and 52.36 dB (4,000 Hz). There was typical high frequency loss (C5-dip at 4,000 Hz) above 30 - 40 dB in normal hearing level. The increasing trend in hearing threshold level was gradually decreased by the increase of PTAs. The difference between PTAs and threshold at 4,000 Hz was about 10 dB. CONCLUSIONS: We could found that PTAs in the previous examination were not appropriately evaluated. This study revealed that they did not use unique criteria for managing the workers of NIHL. For the prevention of NIHL, it was found that the quality control on diagnosis and comprehensive management program were required, especially for those of hearing loss (C).

Perda auditiva induzida pelo ruído em trabalhadores industriais da Regiäo Metropolitana de Salvador, Bahia / The noise-induced hearing loss in industrial workers of Metropolitan Region, Salvador, Bahia, Brazil

O presente trabalho constitui-se em um estudo de prevalência, realizado a partir de dados audiométricos referentes a 7.925 trabalhadores de 44 empresas industriais de nove diferentes ramos de atividade. A prevalência de perda auditiva foi de 45,9% na população estudada. Em relação à perda auditiva do tipo induzida pelo ruído (PAIR), somando as perdas bilaterais e unilaterais, observou-se uma prevalência de 35,7%. Para cada ramo, as prevalências foram as seguintes: 58,7% no editorial/gráfico, 51,7% no mecânico, 45,9% no de bebidas, 42,3% no químico/petroquímico, 35,8% no metalúrgico, 33,5% no siderúrgico, 29,3% no de transportes, 28,0% no de alimentos e 23,4% no têxtil. Chamam atenção as altas prevalências de PAIR unilateral - 18% dos trabalhadores avaliados. O presente estudo permitiu delinear um quadro extremamente alarmante, dada a magnitude da prevalência de perda auditiva do tipo induzida pelo ruído, apontando a importância da implementação, por parte das empresas, de Programas de Conservação Auditiva.

An audiometric evaluation was conducted in 7,925 workers of fourty-four industrial companies in nine different fields of activity. The hearing loss prevalence was 45.9%. The noise-induced hearing loss (NIHL) prevalence was 35.7% considering bilateral and unilateral losses. For each field of activity, the prevalence estimates were: 58.7% in the graphic, 51.7% in the mechanic, 45.9% in the beverage industry, 42.3% in the chemical/ petrochemical, 35.8% in the metallurgy, 33.5% in the metallurgy of iron and steel, 29.3% in the transport companies, 28.0% in the alimentation industry and 23.4% in the textile industry. Unilateral NIHL was surprisingly high - 18% of the examined workers. These results reveal a serious situation and the authors recommend the implementation of Hearing Conservation Programs in industrial companies.

Mitochondrial DNA and GJB2 Genovariation in Noise-Induced Hearing Loss in the Army / 听力学及言语疾病杂志

Objective To explore the relationship between mitochondrial DNA gene,GJB2 gene mutations and the susceptibility to noise-induced hearing loss in the army,and to provide scientific evidence for gene screening of susceptible individuals and relevant molecular epidemiology.Methods 182 blood samples were collected from 349 soldiers,consisting of susceptible and tolerance groups exposed to military noise in Beijing.Genomic DNA was isolated,and the targeted fragments of mitochondrial DNA and coding region of GJB2 gene were amplified by polymerase chain reaction(PCR).The PCR products were analyzed by direct sequencing.Results The results revealed that there were 98 mtDNA variants(41 reside in 12SrRNA) and 12 GJB2 gene variants;among them,mtDNA T1095C and G7642A coexisted in 4 susceptible individuals,but these mutations were not found in the tolerance group.In addition,3 tolerant individuals carried 961delT+insC while no one was found in the susceptible group.Conclusion The 12SrRNA is an area evidenced by high variant and mutation rate.The coexistence of mtDNA T1095C and G7642A in the susceptible group exposed to the similar noise suggests that these mutations are pathogenic mutations associated with NIHL.Three tolerant individuals with the history of long-term noise exposure carry 961delT+insC,suggesting that 961delT+insC might be a conditional pathogenic mutation,but not correlate with NIHL.

The effects of aircraft noise on the hearing loss, blood pressure and response to psychological stress / 예방의학회지

In effort to determine whether aircraft noise can have health effects such as hearing loss, hypertension and psychological stress, a total of 111 male professors and administrative officers working a college near a military airport in Korea(exposed group) and a total of 168 males and 112 females matched by age groups(control groups) were analyzed. Personal noise exposure and indoor and outdoor sound level of jet aircraft noise were measured at the exposed area. And pure tone, air conduction test and measurement of blood pressure were given to the exposed(males) and matched control groups(males and females). BEPSI(Brief Encounter Psychological Instrument) and psychological response to aircraft noise were examined for the exposed group. The noise dosimetry results revealed time-weighted averages(TWAs) that ranged from 61 to 68 dBA. However the levels encountered during taking off jet airplanes reached 126 dBA for two half minutes time period. The audiometric test showed that mean values of HTL(hearing threshold level) in exposed group at every frequency(500, 1,000, 2,000, 4,000, and 8,000 Hz were much lower than them of male and female control groups. And in old age groups, interaction of age and noise was observed at 8,000 Hz in both ears(p< 0.05). Conclusively, aircraft noise does not appear to induce hearing loss directly, but may decreased hearing threshold level by interaction of aging process and noise exposure. However, difference of mean values of exposed and control groups on blood pressure was not significantly. In psychological test, annoyance was the most severe psychological response to noise in exposed group, but mean value of BEPSI was not correlated with job duration in exposed group

Application of HHIE-S(Hearing Handicap Inventory for the Elderly-Screening version) to screening test of noise-induced hearing loss / 예방의학회지

The study conducted from May to September in 1994 to investigate applicability of the Hearing Handicap Inventory for the Elderly-Screening version(HHIE-S) in parallel with the puretone audiometer to the initial screening test of noise-induced hearing loss(NIHL) in some noise-exposed workers. Subjects were selected by systemic sampling that took every fifth person from 6,700 workers taking the annual occupational health examination by the department of Health Maintenance of Dongsan Hospital Keimyung University in Taegu. The authors administered the pure-tone audiometric test and self-reported questionnaire of HHIE-S including items of sociodemographic and job-related variables concurrently. The final subjects analysed were 1,019(488 males and 531 females) excluding fourteen persons who had many missing values in their questionnaires. The reliability coefficients of HHIE-S scale by Cronbach's alpha were 0.84. In the univariate analysis of hearing handicap measured by the HHIE-S, work duration, military service and the hearing threshold loss at 1kHz and 4kHz was the only selected variable explaining the hearing handicap in males and hearing threshold loss at 1kHz and 4kHz, age, and work duration were selected in females. In ROC curves for HHIE-S scores against NIHL as gold standard which was defined by the follow-up audiogram as more than 30dB of the average of 0.5/1/2kHz and 50dB at 4kHz, the optimal cutoff for the parallel HHIE-S appeared to be 8. The results suggest that HHIE-S appeared to have some reliability and validity in this data and might be used in screening NIHL in parallel with pure-tone audiometer in noise-exposed workers.

Development of Quick Screener Based on Embedded System for Noise-induced Hearing Loss / 医疗卫生装备

Objective To develop a portable and automatic quick screener for noise-induced hearing loss(NIHL),which is suitable for airman and ground crew.Methods Through using audio decoder chip VS1003 to achieve quick screener for noise-induced hearing loss and pre-exposing for special background noise.LPC2148 of ARM7-TDMI configuration was adopted as main controlling chip,and its software design was completed by multitask scheduler based on UCOS-Ⅱ,while the FAT system controlled the read-write to the files in SD card.The signal emergence,change in hearing class,frequency selection as well as records of subject reaction were automatically achieved.Results The system can produce stable signal of exact frequency according to GBZ49-2002 Diagnostic Criteria of Occupational Noise-induced Hearing Loss to output stability of the frequency and intensity of the audio signal,and the specific context of the noise pre-exposure function with screening of hearing impairment was achieved automatically.Conclusion Based on the great power of embedded system and VS1003,the portable and automatic quick screener for noise-induced hearing loss(NIHL) can be developed to carry out many functions,which has several features,such as simple structure,high integration,good stability and use of flexible etc.