Synthesis and antifungal activity of 6-bromo-2[(4-(2,3-dichlorophenyl)) piperazine-1-yl)methyl]-3-[8-hydroxy quinoline -5-yl]-3-quinazolin -4-one ligand and its transition metal chelates.

The present investigation involved the synthesis of novel ligand HL14 and its chelate complexes with Cu(II), Ni(II), Co(II), Mn (II) and Zn(II). The characterization studies of chelates were conducted using various physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectral data. The stoichiometry of the complex has been carried out and found to be 1: 2 (Metal: ligand). An octahedral geometry around Co (II), Ni (II) and Mn (II), distorted octahedral geometry around Cu (II) and tetra hedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was performed against various fungi.