ABSTRACT
Background: Perinatal asphyxia is a major cause of acute mortality and chronic neurologic disability amongst survivors, and is a complication that occurs between 2-10% of deliveries. No single parameter can define perinatal asphyxia, rather a combination of parameters like fetal distress, meconium-stained liquor, low Apgar score, umbilical cord blood pH and clinical features of hypoxicischemic encephalopathy (HIE) can predict it. Aim: To study the correlation between nucleated red blood cell count (NRBC), fetal acidosis and clinical markers of asphyxia. Materials and methods: 52 pregnant women with fetal distress as a study group and 51 pregnant women without distress as a control the ed group were selected and their cord blood was analyzed for pH and nucleated RBCs. The results were analyzed. Result: Higher NRBC count was detected in the study group with signs of asphyxia (Thick MSAF, Non-Reassuring FHR Pattern, Low APGAR score). Conclusion: NRBC count is a simple bedside test to diagnose fetal asphyxia. Since it is cost-effective and does not require any special expertise or any high-tech facilities, it may be a useful, reliable, inexpensive and easily available markan er to evaluate perinatal asphyxia, especially in a resourcepoor country like ours, where blood gas analysis facilities are not available in the majority of place.
ABSTRACT
Objective To evaluate the nucleated red blood cell (NRBC)count of Sysmex XN-9000 automatic hematology anal-ysis lines comparing with manual method,and verify the accuracy of the analyzer results.Methods 60 blood samples with more than 1% of NRBCs detected by XN-9000 were counted NRBCs by traditional manual microscopy in blood smears,and verified the analyzer results.Results According to the reliability analysis,the results of total 60 samples were all within the range of the reliability;correlation analysis showed that correlation coefficient (r)of group NRBC (%)1~10 and>10 were 0.972 1 and 0.996 2,respectively.There were no significant differences between them (P>0.05).Conclusion Compared with manual method,the results of NRBC count of XN-9000 were within the range of reliability,and showed good correla-tion.The analyzer test results of NRBC were accurate and reliable and could be applied to the detection of clinical samples.