ABSTRACT
Conidiobolomycosis/Nasofacial zygomycosis is a relatively rare disease entity. It is almost always caused by Conidiobolus coronatus and is also known as conidiobolomycosis. It has been more commonly reported in tropical countries than in other regions. Diagnosis is made mainly on a clinical and pathological basis as fungal cultures may be difficult to grow. Different antimycotic drugs have been tried for its treatment. This report probably is the first case in English literature that has shown a very good response to treatment with itraconazole.
Subject(s)
Conidiobolus , Diagnosis , Itraconazole , Rare Diseases , ZygomycosisABSTRACT
São descritos dois casos de zigomicose nasofacial, procedentes de Belém, PA. O achado indica não ser tão rara, como se poderia supor, pela falta de registros, a ocorrência dessa micose na Região Norte do Brasil. Em ambos os pacientes, o tratamento pelo cetoconazol determinou involução rápida das manifestações clínicas, principalmente a obstrução nasal. Com o presente relato, sobe para cinco o número de casos da infecção referidos até agora do Estado do Pará.
Two new cases of nasofacial zygomycosis from the state of Pará, Brazil, are reported. Both cases were treated with ketoconazole and the response to the drug was considered to be good; the patients improved rapidly and the nasal obstruction was the first manifestation to disappear. As five cases have been described in recent years from the state of Pará, this form of zygomycosis can no longer be considered as a rare disease in northern Brazil.