ABSTRACT
SUMMARY Halzoun syndrome, also known as nasopharyngeal linguatulosis, is a rare entity that is mostly prevalent in Eastern Mediterranean countries. The consumption of raw ovine liver and lymph nodes infested with Linguatula serrata nymphs remains a major cause of the nasopharyngeal symptoms and discomfort associated with the disease. Halzoun syndrome is a clinical diagnosis based on history and presentation. Treatment of this disease is still debated; however, our experience reveals that alcohol gargle can be a good option. Proper counselling on the hazards of eating raw liver in endemic areas is needed. Moreover, physicians should be aware of the sequence of events in the disease in order not to delay or miss the diagnosis. This communication presents a rare Lebanese case of Halzoun syndrome that offers medical implications in the clinical diagnosis and treatment of the nasopharyngeal symptoms of this syndrome, with a review of the literature.
RESUMO Esta comunicação apresenta um caso libanês raro de síndrome de Halzoun que oferece implicações médicas no diagnóstico clínico e no tratamento dos sintomas nasofaríngeos desta síndrome, com uma revisão da literatura. A síndrome de Halzoun, também conhecida como linguatulose nasofaríngea, é uma entidade rara predominante nos países do Mediterrâneo Oriental. O consumo de linfonodos ovinos e linfáticos ovinos infestados com ninfas Linguatula serrata continua a ser uma das principais causas dos sintomas nasofaríngeos e do desconforto associado à doença. A síndrome de Halzoun é um diagnóstico clínico baseado na história e na apresentação. O tratamento dessa doença ainda é debatido; no entanto, nossos resultados revelam que o gargarismo de álcool pode ser uma boa opção. É necessário um aconselhamento adequado sobre os perigos de comer fígado cru em áreas endêmicas. Além disso, os médicos devem estar cientes da sequência de eventos na doença, a fim de não atrasar ou perder o diagnóstico.
Subject(s)
Humans , Animals , Female , Young Adult , Parasitic Diseases/parasitology , Nasopharyngitis/parasitology , Pentastomida , Foodborne Diseases/parasitology , Parasitic Diseases/diagnosis , Parasitic Diseases/drug therapy , Nasopharyngitis/diagnosis , Nasopharyngitis/drug therapy , Foodborne Diseases/diagnosis , Foodborne Diseases/drug therapyABSTRACT
Objective:To systematically review the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs)on two common respiratory system adverse events (RSAE:nasopharyngitis and upper re-spiratory tract infection)among type 2 diabetes (T2DM).Methods:Medline,Embase,Clinical trials and Cochrane library were searched from inception through May 201 5 to identify randomized clinical trials (RCTs)assessed safety of GLP-1 RAs versus placebo or other anti-diabetic drugs in T2DM.Network meta-analysis within a Bayesian framework was performed to calculate odds ratios for the incidence of RSAE.Results:In the study,50 RCTs were included,including 1 3 treatments:7 GLP-1 RAs (exenati-de,exenatide-long-release-agent,liraglutide,lixisenatide,taspoglutide,albiglutide and dulaglutide), placebo and 5 traditional anti-diabetic drugs(insulin,metformin,sulfonylureas,sitagliptin and thiazo-lidinediones ketones).Compared with insulin,taspoglutide significantly decreased the incidence of naso-pharyngitis (OR =0.67,95%CI:0.46 -0.96).Significant lowering effects on upper respiratory tract infection were found when taspoglutide versus placebo (OR =0.57,95%CI:0.34 -0.99)and insulin (OR =0.39,95%CI:0.23 -0.73).The result from the network meta-analysis based on Bayesian theo-ry could be used to rank all the treatments included,which showed that taspoglutide ranked last with mi-nimum risk on nasopharyngitis and upper respiratory tract infection.Conclusion:Taspoglutide was associ-ated with significantly lowering effect on RSAE.
ABSTRACT
Acute nasopharyngitis is one of the distressing adverse effects seen with the use of dipeptidyl peptidase-4 inhibitors like sitagliptin. Here, we report a case of acute severe nasophryngitis with the use of sitagliptin for diabetes mellitus.
ABSTRACT
La infección respiratoria es la enfermedad más frecuente en los seres humanos, pues es responsable de la mitad de todas las enfermedades agudas. En Cuba al igual que en el resto del mundo, el asma bronquial constituye un importante problema de salud con incidencia relevante en los niños. Se señala que las infecciones virales están involucradas en la patogénesis del asma, sobre todo en el paciente pediátrico. Objetivo: identificar la influencia de las Infecciones Respiratorias Agudas Altas en la aparición y exacerbación de las crisis de asma bronquial. Métodos: se realizó un estudio descriptivo, transversal y prospectivo de los pacientes ingresados con asma bronquial en el servicio de enfermedades respiratorias del Hospital Pediátrico Docente de San Miguel del Padrón, durante todo el año 2008. Resultados: el tiempo de evolución de la IRAA más frecuente que desencadenó la crisis de asma bronquial fue de más de 7 días, con un 54,8 por ciento. Un total de 188 pacientes presentaron rinofaringitis aguda catarral relacionada con la aparición de la crisis de asma bronquial, lo que representó el 82,4 por ciento del total de la muestra. Conclusiones: predominó el grupo de 1 a 4 años con manifestaciones respiratorias altas de posible etiología viral sin diferencias apreciables en relación con el sexo.La mayoría de los pacientes que participaron en el estudio presentaron IRAA de etiología viral (Rinofaringitis), que precedieron la aparición y exacerbación de las crisis agudas de asma bronquial...
Respiratory infection is the most common disease in humans; it is responsible for half of all acute diseases. In Cuba, as in the rest of the world, asthma is a major health problem with significant impact on children. It is noted that viral infections are involved in asthma pathogenesis, especially in pediatric patients. Objective: t o identify the influence of Acute High Respiratory Infections (AHRI) in the onset and aggravation of bronchial asthma crisis.Methods: a descriptive, cross-sectional and prospective study was conducted on hospitalized patients due to asthma in the service of respiratory diseases at the Pediatric Teaching Hospital in San Miguel del Padrón, during 2008. Results: the duration of the most common AHRI that triggered the asthma crisis was more than 7 days 54.8 percent. A total of 188 patients had acute catarrhal nasopharyngitis related to the onset of asthma crisis, which represented 82.4 percent of the total sample. Conclusions: the age group of 1 to 4 years had more upper respiratory manifestations of possible viral etiology with no noticeable differences in relation to gender. Most patients in this study had viral etiology AHRI (nasopharyngitis), which preceded the onset and aggravation of acute attacks of bronchial asthma...