ABSTRACT
OBJECTIVE:To observe clinical efficacy and safety of Tobramycin dexamethasone ointment in Nd∶YAG laser lac-rimal duct plasty. METHODS:Medical records of 1000 patients(1250 eyes)with obstructive lacrimal duct disease receiving To-bramycin dexamethasone ointment in Nd∶YAG laser lacrimal duct plasty were selected from our hospital during Jan. 2013-Jan. 2017. They were divided into chronic dacryocystitis group(380 eyes),small tears(total)tube obstruction group(360 eyes),naso-lacrimal duct obstruction group (342 eyes),punctal occlusion group (86 eyes) and traumatic canalicular laceration group (82 eyes)according to the lacrimal duct obstruction. In 5 groups,heated Tobramycin and dexamethasone ophthalmic ointment would be loaded in 1 mL syringe and injected into the lacrimal duct via probe,dropping the probe while pushing the ointment. They received lacrimal duct flushing regularly and were followed up for 3 months. Therapeutic efficacies and safty were compared among 5 groups. RESULTS:Cure rate and response rate of patients with chronic dacryocystitis were 85.00％ and 87.63％;those of patients with lacrimal small (total) obstruction were 87.78％ and 94.45％;those of patients with nasolacrimal duct obstruction were 89.18％ and 95.03％;those of patients with punctal occlusion were 84.88％ and 94.18％. All of above were significantly higher than 42.68％and 64.63％of patients with traumatic canalicular laceration,with statistical significance(P<0.05). There was no sta-tistical significance in the incidence of ADR among 5 groups(P>0.05). CONCLUSIONS:In the treatment of chronic dacryocysti-tis,small tears(total)tube obstruction,nasolacrimal duct obstruction and punctal occlusion,application of Tobramycin dexametha-sone eye ointment in Nd∶YAG laser lacrimal duct plasty shows good therapeutic efficacy and has less ADR.