ABSTRACT
Diabetes mellitus is a common condition which frequently has skin manifestations. The attachment of glucose to protein may result in a profound effect on structure and function of that protein, and account for clinical manifestations of the disease. The present study was undertaken to assess the incidence and to compare the incidence of waxy skin and scleroderma in diabetics and non diabetics. The study was done on 250 patients who attended the Skin OPD of Guru Nanak Dev Hospital, Amritsar. Thorough general physical examination and the dermatological examination were done in each case. All the cases of collagen disorders necrobiosis lipoidica diabeticorum, granuloma annulare, scleroedema diabeticorum, waxy skin and limited joint mobility were noted and compared between diabetics and non diabetic patients.
ABSTRACT
Necrobiosis lipoidica diabeticorum is a rare disease and possibly confused with another conditions such as sarcoid disease, rheumatic pimple … In its histopathological study, it must consider the histochemical methods in detecting the damage of connective fiber tissues as well as clinical signs of the disease. The gender ratio is 1/3 (male/female), the mean age of onset is 30 years old. The necrotic lipoid tissue can occur in various areas – thigh, leg, foot, hand and head skin, most commonly in the right face of the leg
Subject(s)
Diagnosis , Necrobiosis Lipoidica , TherapeuticsABSTRACT
The isomorphic response of Koebner is a well-known phenomenon commonly associated with psoriasis, but it has been also described in conjuction with a host of other disorders. However it has seldom been associated with necrobiosis lipoidica diabeticorum, a rare skin manifestation of diabetes mellicuts. In this report, we describe a 59-year-old woman who developed necrobiosis lipoidica diabeticorum on the left shin where a mosquito had bitten her 2 months ago. Four months ago, she was diagnosed as necrobiosis lipoidica diabeticorum on the right forearm and shin by biopsy and the lesions were improved with corticosteroids intralesional injection. The lesions were asymptomatic and had grown slowly. Histopathological findings showed a large palisading granulomas composed of histiocytes, epithelioid cells and areas of necrobiosis of collagen with multinucleated giant cells. Van Gieson stain showed decreased and fragmented elastic fibers and there were no deposits of mucin in the necrobiotic areas. The lesions were improved with triamcinolone acetonide intralesional injection and there was no recurrence during 4 months.