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BACKGROUND: Salvia injection and needle-knife therapy are commonly used techniques in the treatment of osteoarthritis in clinical practice. At present, there is no research on the combination of the two methods. OBJECTIVE: To compare the effects of needle-knife therapy and salvia injection and their combinations in the treatment of osteoarthritis in rabbit models. METHODS: The study was approved by the Laboratory Animal Ethical Committee of Heilongjiang University of Chinese Medicine. Fifty New Zealand white rabbits were divided into five groups: Blank control, model, salvia injection, needle-knife, and combination groups. The rat models of osteoarthritis were established in all groups except for blank control group. After successful modeling, medial and lateral patellar retinaculums, medial and lateral knee eyes, suprapatellar bursa, muscle belly of each quadriceps femoris, muscle belly and ending point of gracilis, muscle belly and ending point of adductor and area surrounding the tibial plateau of rats in the needle-knife group received needle-knife release. The rabbits in the blank control and model groups underwent the intra-articuiar injection of normal saline (0.3 mL). The rabbits in the salvia injection group were given the intra-articuiar injection of salvia (0.3 mL). The rabbits in the combination group received needle-knife release, followed by intra-articuiar injection of salvia (0.3 mL). All interventions were conducted weekly, for 5 consecutive weeks. The knee articular cartilage underwent gross observation and histological observation. The levels of interleukin-1 and tumor necrosis factor-alpha in synovial fluid were detected by ELISA. RESULTS AND CONCLUSION: (1) Gross observation: The worn artificial knee in the model group was serious, and was slight in the salvia injection, needle-knife, and combination groups. (2) Pathological scores: The scores in the salvia injection group were slightly higher than those in the needle-knife and combination groups. (3) ELISA results: The levels of interleukin-1 and tumor necrosis factor-alpha in the combination group were significantly lower than those in the salvia injection and needle-knife groups (P < 0.05). (4) In summary, needle-knife therapy combined with intra-articuiar injection of salvia is superior to needle-knife therapy alone or intra-articuiar injection of salvia in reducing the levels of interleukin-1 and tumor necrosis factor-alpha in rabbit models of osteoarthritis.
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OBJECTIVE@#To compare the effect difference between needle-knife therapy combined with moxa stick pressure moxibustion and western medicine for cervical vertigo.@*METHODS@#A total of 60 cervical vertigo patients were randomized into an observation group and a control group, 30 cases in each group. The patients in the observation group were treated with needle-knife therapy combined with moxa stick pressure moxibustion at Baihui (GV 20), Shenting (GV 24), Tianzhu (BL 10), Yuzhen (BL 9), Touwei (ST 8), etc. The needle-knife therapy was given once a week, 1-3 times. The pressure moxibustion was given once a day, 6 times a week. The patients in the control group were received 12 mg of betahistine mesylate, twice a day, and 75 mg of diclofenac sodium double release capsule, once daily for oral treatment. The treatment was given for 3 weeks in both groups. The symptom and functional evaluation scale of cervical vertigo were observed before and after treatment and 3 months after treatment. The long-term effect was observed 3 months after treatment.@*RESULTS@#The total effective rate in the observation group was 93.3% (28/30), which was significantly higher than 63.3% (19/30) in the control group (<0.05). Compared with those before treatment, the scores of vertigo symptom and functional evaluation scale, dizziness, neck and shoulder pain, headache, daily life, psychological and social adaptability were increased in the two groups (<0.05, <0.01). Except for a slight decrease in headache and total score at the follow-up period in the observation group, the remaining 4 individual scores were higher than those after treatment (all <0.05). At follow-up, the total score and five individual scores were lower than those after treatment in the control group (<0.05, <0.01). Compared with those in the control group, the vertigo scale scores and the five individual scores in the observation group were increased significantly after treatment and at follow-up (<0.05, <0.01).@*CONCLUSION@#Needle-knife therapy combined with moxa stick pressure moxibustion can significantly relieve dizziness, headache, neck and shoulder pain in patients with CV, and can improve the quality of life . The combination therapy are better than western medicine, and have a better long-term effect.
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Humans , Acupuncture Therapy , Moxibustion , Quality of Life , Treatment Outcome , Vertigo , TherapeuticsABSTRACT
Objective To systematically evaluate the efficacy of small-needle-knife therapy combined with manipulation in treating frozen shoulder. Methods Articles about small-needle-knife therapy combined with manipulation treating frozen shoulder clinical randomized controlled trials in CNKI, CBM, VIP, Wanfang Data, Embase, Cochrane Library and Pubmed database were searched. Retrieval time was from the establisment of the database to February 2017. Two researchers screened literature, extract materials independently. The quality of the included studies was evaluated according to the Cochrane System Evaluation Manual 5.1.0. Meta-analysis was performed by using RevMan 5.3 software. Results 12 articles were included in a systematic review, a total of 1118 cases of patients. Meta-analysis showed that, compared with small-needle-knife therapy alone, small-needle-knife therapy combined with manipulation in the treatment of frozen shoulder could significantly improve the total effective rate [OR=5.07, 95%CI(3.07, 8.37), P<0.000 01] and cure rate [OR=2.89, 95%CI(2.21, 3.78), P<0.000 01], enhance motor function score [MD=63.98, 95%CI(38.61, 89.35), P<0.000 01], with statistical significance. Conclusion Small-needle-knife therapy combined with manipulation had definite efficacy in the treatment of frozen shoulder. However, the quality of included research is relatively low, so large-sample, multi-center and high-quality randomized controlled trials are required for verification.
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<p><b>OBJECTIVE</b>To compare the therapeutic effects between needle knife therapy combined with rotation traction manipulation and rotation traction manipulation for the treatment of cervical spondylotic radiculopathy.</p><p><b>METHODS</b>From November 2013 to June 2015, 80 patients with cervical spondylotic radiculopathy meeting the inclusion criteria were divided into two groups randomly:the control group in which 39 patients were treated with rotation traction manipulation, and the treatment group in which 41 patients were treated with needle knife combined with rotation traction manipulation. The patients in the control group were treated once dayly for 2 weeks, which was 1 course. The patients in the treatment group were treated with needle knife firstly once a week for 2 weeks, which was 1 course;then were treated with the same methods as the patients in the control group. The symptoms, signs score and the therapeutic effects of the two groups before and after treatment were observed.</p><p><b>RESULTS</b>After treatment, symptoms and signs scores declined in both groups(<0.05). The results of the treatment group were better than effects in the control group(<0.05). In the treatment group, 19 patients got an excellent result, 16 good, 5 fair and 1 bad;while in the control group, 10 patients got an excellent result, 10 good, 16 fair and 3 bad;the results of the treatment group were better than the results of the control group(<0.01).</p><p><b>CONCLUSIONS</b>Needle knife combined with rotation traction manipulation is an effective method for the treatment of cervical spondylotic radiculopathy, which is better than using manipulation method simply. Needle knife therapy has follow advantages:improving local blood circulation, reducing local content of pain substance, increasing production of substances resisting pain, opening channels and collaterals, and make body reaching new static and dynamic balance on the new foundation.</p>
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Objective To compare the clinical effect of needle knife therapy and traction for treatment of cervical spondylosis .Methods 156 patients with nerve root type of cervical spondylosis patients definitely diag -nosed,randomly divided into two groups ,the treatment group of 78 cases,with small needle knife therapy;the control group of 78 cases,the cervical traction therapy ,combined with traditional Chinese medicine .The clinical efficacy was compared between the two groups .Results The treatment group 70 cases were cured(89.6%),the total efficiency of 96.9%;control group 44 cases were cured(56.7%),the total efficiency of 83.3%.The cure rate and total effective rate was significantly better than the control group (χ2 =22.02,11.57,all P<0.05).Conclusion The needle knife therapy to treat cervical vertebra disease is better than that of cervical traction ,has good clinical curative effect .