ABSTRACT
Cellular neurothekeoma (CNT) is an uncommon variant of neurothekeoma that is composed of pithelioid to spindled cells with variable nuclear atypia or pleomorphism but no myxoid stroma. CNT occurs predominantly in the head and neck or upper trunk of children and young adults, with female predominance. The following case is different from typical CNTs. An 88-year-old female presented with a palpable mass on the scalp, which we excised. Histologically, the tumor was non-encapsulated and composed of spindled and epithelioid cells arranged in fascicles and nodules separated by a collagen-rich stroma. Immunohistochemical analysis showed that the epithelioid and spindle-shaped cells were focally positive for vimentin, neuron-specific enolase, smooth muscle actin, CD68, and CD10 but negative for S-100 protein, HMB-45, epithelial membrane antigen, and CD34. We report a new case of CNT that arose in the scalp of an older patient and that was associated with uncommon clinical, histological, and immunohistochemical profiles.
Subject(s)
Aged , Aged, 80 and over , Child , Female , Humans , Young Adult , Actins , Epithelioid Cells , Head , Mucin-1 , Muscle, Smooth , Neck , Neurothekeoma , Phosphopyruvate Hydratase , S100 Proteins , Scalp , VimentinABSTRACT
Cellular neurothekeoma (CNT) is an uncommon variant of neurothekeoma that is composed of pithelioid to spindled cells with variable nuclear atypia or pleomorphism but no myxoid stroma. CNT occurs predominantly in the head and neck or upper trunk of children and young adults, with female predominance. The following case is different from typical CNTs. An 88-year-old female presented with a palpable mass on the scalp, which we excised. Histologically, the tumor was non-encapsulated and composed of spindled and epithelioid cells arranged in fascicles and nodules separated by a collagen-rich stroma. Immunohistochemical analysis showed that the epithelioid and spindle-shaped cells were focally positive for vimentin, neuron-specific enolase, smooth muscle actin, CD68, and CD10 but negative for S-100 protein, HMB-45, epithelial membrane antigen, and CD34. We report a new case of CNT that arose in the scalp of an older patient and that was associated with uncommon clinical, histological, and immunohistochemical profiles.
Subject(s)
Aged , Aged, 80 and over , Child , Female , Humans , Young Adult , Actins , Epithelioid Cells , Head , Mucin-1 , Muscle, Smooth , Neck , Neurothekeoma , Phosphopyruvate Hydratase , S100 Proteins , Scalp , VimentinABSTRACT
El Neurotecoma Celular es un raro tumor benigno de histopatogénesis incierta extremadamente atípico. Clínicamente la lesión es poco característica, generalmente es un nódulo solitario asintomático de crecimiento lento que se puede presentar en piel y mucosas. El diagnóstico se basa en los hallazgos histológicos y de inmunohistoquímica, se considera que los neurotecomas en sus distintas variantes: mixoide, celular o mixta forman parte de un espectro de tumores con un supuesto origen en la vaina nerviosa, sin embargo numerosos autores afirman que se trata de tumores diferentes que justifican una clasificación separada. A nivel mundial existen tan solo alrededor de 300 reportes de este tipo de tumoración, por ello el interés de presentar el caso de un paciente masculino de 13 años de edad quien ingreso y fue tratado por el servicio de cirugía plástica y reconstructiva del hospital universitario de los andes y quien curso con una neoformación de aproximadamente 30mm de diámetro, firme, de crecimiento lento, localizada en la porción del margen derecho de la lengua con 14 meses de evolución. El diagnóstico histopatológico confirmó un Neurotecoma Celular(AU)
The Cell Neurothekeoma is a rare benign tumor of uncertain histopatogenesis extremely atypical. Clinicallyncharacteristic lesion, usually an asymptomatic solitary nodule of slow growth. It can occur in the skin and mucous membranes. The diagnosis is based on histological and immunohistochemically findings, the neurotecomas are considered that in its different considered that in its different variants: myxoid, mixed cell or mixed, are a part of putative origin tumors in the nerve sheath, however many authors claim that this are different tumors that justify a separate classification. Worldwide there are only about 300 reports of this type of tumor so the interest of presenting the case of a male patient of 13 years old who income and was treated by the service of plastic and reconstructive surgery at the Andes University Hospital and he coursed with a new formation of approximately 30mm diameter, firm, slow-growing, located in the right lateral portion of the tongue with 14 months duration. Histopathological diagnosis confirmed a Cell Neurothekeoma(AU)
Subject(s)
Humans , Male , Adolescent , Mouth Neoplasms , Tongue Neoplasms , Neurothekeoma/pathology , Surgery, Oral , Medical OncologyABSTRACT
PURPOSE: Nerve sheath myxoma is a rare cutaneous neoplasm originating from the peripheral nerve sheath and divided into three groups : myxoid, cellular and mixed type. There is a controversy on it's origin whether schwannian cell or perineurial differentiation, or anything else. Myxoid nerve sheath myxoma is asymptomatic, soft, papule or nodule in middle-age adults. We report a case of myxoid nerve sheath myxoma on the fingertip. METHODS: A 53-year-old woman presented with a painful, 0.4 x 0.4 x 0.6 cm sized, corn shaped nodule on the left 3rd fingertip. We put into surgical excision and studied it by histopathologically and specific immnohistochemical stain. RESULTS: The tumor has well defined nodules separated by thin fibrous connective tissue with abundant myxoid stroma and were positively stainded for S-100 protein, NSE and GFAP. After surgical treatment it was healed without recurrence. CONCLUSION: Nerve sheath myxoma is rare neoplasm and located mainly on face, but very rarely on the fingertip. We report a case of painful myxoid nerve sheath myxoma located on the 3rd fingertip.
Subject(s)
Adult , Female , Humans , Middle Aged , Connective Tissue , Neurothekeoma , Peripheral Nerves , S100 Proteins , Zea maysABSTRACT
Nerve sheath myxoma(NSM) is rare benign neoplasm of the dermis, divided into myxoid, cellular and mixed types. Myxoid NSM is asymptomatic, soft, skin colored or translucent papule or nodule in middle-aged adults and typically located on the face and the upper extremities. We, herein, reported a case of myxoid NSM in a 3 1-year -old male who had a painful, 1 X 1cm sized, dome-shaped nodule on the left sole.
Subject(s)
Adult , Humans , Male , Dermis , Neurothekeoma , Skin , Upper ExtremityABSTRACT
Neurothekeoma is a relatively uncommon tumor of nerve sheath origin. Most of these tumors are benign and malignant transformation was not reported. Usually, these tumors arise during childhood or early adulthood life with female preponderance. They have a predilection for the head, neck and shoulder region but any part of the body may be affected. Their usual size is between 0.5-3.0 cm. Rapid growth and ulceration are rare, and local recurrence tends to occur after incomplete excision. We report a case of neurothekeoma developed in the scalp of a 21-year-old woman. It was first noticed about 1year ago. This mass had been increasing in size slowly. On physical examination, 2 x 1.5 cm sized papule with localized alopecia was identified on the frontal scalp area. It was excised in 5.5 x 3.6 cm. The histologic finding of the lesion showed that lobules, fascicles or rests of spindle shaped or epitheloid cells in a myxoid of mucosubstance. The tumor cells were positive for S-100 and vimentin but showed negative for EMA, cytokeratin, desmin, actin and HMB45. After surgical excision of tumor, split-thickness skin graft was done. Three months after the operation, rectangular shape tissue expander (180 cc Sebbin(R)) was inserted on both sides of the previous wound. After removal of tissue expander, the wound closed with local flap. The patient did not have any evidence of recurrence for 6 months.
Subject(s)
Female , Humans , Young Adult , Actins , Alopecia , Desmin , Head , Keratins , Neck , Neurothekeoma , Physical Examination , Recurrence , Scalp , Shoulder , Skin , Tissue Expansion Devices , Transplants , Ulcer , Vimentin , Wounds and InjuriesABSTRACT
Nerve sheath myxoma(NSM) is a rare cutaneous neoplasm of uncertain histogenesis. NSM can be divided into two groups; NSM1 (a myxoid NSM) and NSM2 (a cellular neurothekeoma). NSMs are characterized histologically by well-defined, lobular or plexiform dermal proliferation of stellate, spindle-shaped cells embedded in abundant myxoid stroma. A variable amount of nerve fascicles are entrapped within and around the tumor. Two variants of NSM share the same features to a certain degree but differ in cellularity and mucin deposition. We report two cases of NSMs with different clinical and histopathologic features.
Subject(s)
Mucins , NeurothekeomaABSTRACT
We report a case of an uncommon cutaneous neoplasm of nerve sheath myxoma in a 25-year-old woman who had a papule on the left cheek of her face. The histologic findings of the lesion showed that lobulated tumors were composed of spindle shaped and stellate tumor cells in an abundant matrix of mucosubstances. The electron microscopic findings showed numerous cytoplasmic myelin figures, and interdigitating long cytoplasmic processes. 5-100 protein was not discovered and alcian blue and PAS stain showed positive. After surgical excision of tumor, the patient did not have any evidence of disease for one year.