ABSTRACT
Withaferin compounds have attracted increasing attention in nervous system disorders in reecnt years, which has been reported to have excellent neuroprotective role in stroke, spinal cord injury, ncuroinflammation and so on. The effects of withaferin compounds for nervous system disorders are mainly summa rized in this research, including relevant reports and our recent works.
ABSTRACT
Este artigo tem por objetivo caracterizar o perfil epidemiológico das vítimas de afecções neurológicas atendidas por um Serviço de Atendimento Móvel de Urgência. Trata-se de estudo exploratório, descritivo e de abordagem quantitativa dos dados. A coleta foi realizada no período de janeiro a junho de 2016, em um hospital referência em atendimentos de urgência e emergência do estado do Rio Grande do Norte. Foram analisadas 73 ocorrências neurológicas, 38 (52,1%) do sexo masculino, 43 (58,9%) entre a faixa etária de 68 a 101 anos. Quanto à característica da afecção neurológica, 59 (80,8%) sofreram Acidente Vascular Encefálico, oito (11%) crise convulsiva, três (4,1%) lombalgia associada a lesão medular e três (4,1%) eram de outra natureza neurológica. Quanto ao tempo resposta para o atendimento, a média foi de 31 minutos. O perfil epidemiológico identificado foi de homens idosos, que sofreram Acidente Vascular Encefálico e que não receberam atendimento no tempo resposta adequado (AU).
This article aims to characterize the epidemiological profile of individuals with neurological disorders assisted by a prehospital mobile emergency care service. Exploratory and descriptive study with quantitative approach. Data was collected from January to June 2016, in an emergency and urgent care referral center in the state of Rio Grande do Norte. Seventy-three (73) neurological disorders were analyzed: 38 (52.1%) patients were male individuals, 43 (58.9%) were aged between 68 and 101 years. Regarding the characteristics of the neurological condition, 59 (80.8%) patients had a cerebrovascular accident (CVA), eight (11%) had seizures, three (4.1%) had low back pain related to spinal cord trauma and three (4.1%) patients had other types of neurological conditions. As for the response time to care, the average time was 31 minutes. The epidemiological profile identified was elderly men who had CVA (stroke) and whose care needs were not responded within an appropriate time (AU).
Artículo que objetiva caracterizar el perfil epidemiológico de víctimas de afecciones neurológicas atendidas por un Servicio de Atención Móvil de Urgencia. Estudio exploratorio, descriptivo, de abordaje cuantitativo de datos. La recolección se realizó de enero a junio de 2016, en hospital de referencia en atención de urgencias y emergencias del estado de Rio Grande do Norte. Fueron analizados 73 sucesos neurológicos, 38 (52,1%) en pacientes masculinos; 43 (58,9%) pertenecientes a faja etaria de 68 a 101 años. Respecto a características de la afección, 59 (80,8%) sufrieron Accidente Cerebrovascular, 8 (11%) crisis convulsiva, 3 (4,1%) lumbalgia asociada a lesión medular, y 3 (4,1%) fueron de otra naturaleza neurológica. Acerca del tiempo de respuesta, el promedio fue de 31 minutos. El perfil epidemiológico identificado fue de hombres ancianos, que sufrieron Accidente Cerebrovascular y que no recibieron atención en el tiempo de respuesta adecuado (AU).
Subject(s)
Humans , Stroke , Emergency Medical Services , Epilepsy , Nervous System Diseases , Health ProfileABSTRACT
Nervous system infections are among the most important diseases in travellers. Healthy travellers might be exposed to infectious agents of central nervous system, which may require in-patient care. Progressive course is not uncommon in this family of disorders and requires swift diagnosis. An overview of the available evidence in the field is, therefore, urgent to pave the way to increase the awareness of travel-medicine practitioners and highlights dark areas for future research. In November 2013, data were collected from PubMed, Scopus, and Web of Knowledge (1980 to 2013) including books, reviews, and peer-reviewed literature. Works pertained to pre-travel care, interventions, vaccinations related neurological infections were retrieved. Here we provide information on pre-travel care, vaccination, chronic nervous system disorders, and post-travel complications. Recommendations with regard to knowledge gaps, and state-of-the-art research are made. Given an increasing number of international travellers, novel dynamic ways are available for physicians to monitor spread of central nervous system infections. Newer research has made great progresses in developing newer medications, detecting the spread of infections and the public awareness. Despite an ongoing scientific discussion in the field of travel medicine, further research is required for vaccine development, state-of-the-art laboratory tests, and genetic engineering of vectors.
ABSTRACT
Nervous system infections are among the most important diseases in travellers. Healthy travellers might be exposed to infectious agents of central nervous system, which may require in-patient care. Progressive course is not uncommon in this family of disorders and requires swift diagnosis. An overview of the available evidence in the field is, therefore, urgent to pave the way to increase the awareness of travel-medicine practitioners and highlights dark areas for future research. In November 2013, data were collected from PubMed, Scopus, and Web of Knowledge (1980 to 2013) including books, reviews, and peer-reviewed literature. Works pertained to pre-travel care, interventions, vaccinations related neurological infections were retrieved. Here we provide information on pre-travel care, vaccination, chronic nervous system disorders, and post-travel complications. Recommendations with regard to knowledge gaps, and state-of-the-art research are made. Given an increasing number of international travellers, novel dynamic ways are available for physicians to monitor spread of central nervous system infections. Newer research has made great progresses in developing newer medications, detecting the spread of infections and the public awareness. Despite an ongoing scientific discussion in the field of travel medicine, further research is required for vaccine development, state-of-the-art laboratory tests, and genetic engineering of vectors.
ABSTRACT
Nervous system infections are among the most important diseases in travellers. Healthy travellers might be exposed to infectious agents of central nervous system, which may require in-patient care. Progressive course is not uncommon in this family of disorders and requires swift diagnosis. An overview of the available evidence in the field is, therefore, urgent to pave the way to increase the awareness of travel-medicine practitioners and highlights dark areas for future research. In November 2013, data were collected from PubMed, Scopus, and Web of Knowledge (1980 to 2013) including books, reviews, and peer-reviewed literature. Works pertained to pre-travel care, interventions, vaccinations related neurological infections were retrieved. Here we provide information on pre-travel care, vaccination, chronic nervous system disorders, and post-travel complications. Recommendations with regard to knowledge gaps, and state-of-the-art research are made. Given an increasing number of international travellers, novel dynamic ways are available for physicians to monitor spread of central nervous system infections. Newer research has made great progresses in developing newer medications, detecting the spread of infections and the public awareness. Despite an ongoing scientific discussion in the field of travel medicine, further research is required for vaccine development, state-of-the-art laboratory tests, and genetic engineering of vectors.
ABSTRACT
@#ObjectiveTo observe the effect of rat cerebral hemorrhage model via autologous blood injection.MethodsBlood extracted from rats' cardiac ventricles was injected into the right caudate nucleus via stereotactic method. Pathological examination,ultrastructural visualization and motor functional test were applied to validate the feasibility of this method.ResultsRats showed paralysis of left extremities rapidly after surgery. Pathological examination confirmed the formation of hematoma in caudate nucleus. The deviation of hematoma volume and location among individuals was significantly lower than that of rats made by collagenase injection. Transmission electron microscopy showed wide mylin degeneration in right caudate nucleus. Motor functional test revealed the dysfunction of left extremities with marked lower deviation among individuals compared with that of collagenase injection (P<0.05).ConclusionAutologous blood injection can result in significantly lower deviation of hematoma volume and location as well as dysfunctional degree compared with that of collagenase injection.