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RESUMO A partir da experiência do trabalho realizado em uma equipe multiprofissional na Rede Pública de Educação Básica no Município de São Paulo, o texto propõe uma reflexão sobre as ações desses profissionais por meio de uma perspectiva institucional, no apoio ao trabalho docente, no reconhecimento das práticas de educação escolar e nas relações que se estabelecem nesse espaço. Procura identificar os desafios e possibilidades desse trabalho, levando em conta os fatores intraescolares e extraescolares como base nas intervenções, refletindo sobre a queixa escolar e excluindo qualquer prática de patologização e psicologização da vida.
RESUMEN A partir de la experiencia de la labor realizada en un equipo multiprofesional, en la Red Pública de Educación Básica en el Municipio de São Paulo, en el texto se propone una reflexión sobre las acciones de esos profesionales a partir de una perspectiva institucional, en el apoyo a la labor docente, en el reconocimiento de las prácticas de educación escolar y en las relaciones que se establecen en ese espacio. Busca identificar los desafíos y posibilidades de esa labor, llevando en cuenta los factores intra escolares y extraescolares como base en las intervenciones, reflejando la queja escolar y excluyendo cualquier práctica de patologización y psicologización de la vida.
ABSTRACT Based on the experience of work carried out in a multidisciplinary team, in the Public Basic Education Network in the Municipality of São Paulo, the text proposes a reflection on the actions of these professionals from an institutional perspective, in supporting teaching work, in recognizing the school education practices and the relationships that are established in this space. It seeks to identify the challenges and possibilities of this work, taking into account intra-school and extra-school factors as a basis for interventions, reflecting school complaints and excluding any practice of pathologizing and psychologizing life.
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Aim To investigate the pharmacological mechanism of Weimaining in the treatment of lung ade¬nocarcinoma ( LUAD) , using a network pharmacology and molecular docking approach. Methods The active components and potential targets of Weimanin ( Rhizo- ma Fagopyri Cymosi) were screened out through TCM- SP, TCMID, BATMAN-TCM and ETCM data plat-form, and supplemented with literature. The gene ex¬pression data of LUAD were obtained from the Gen Ex¬pression Omnibus database(GEO) , and the differenti¬ally expressed genes were determined using R software. A protein-protein interaction( PPI) network of intersec¬tion targets was constructed by STRING and visualized by Cytoscape software, and GO functional annotation and KEGG pathway enrichment analysis were per¬formed by Metascape platform. Finally, molecular doc¬king studies were carried out to verify the binding of core components and targets. Results Selecting the OB and DL as filter condition, 16 active ingredients and 353 potential targets were involved. MMP-9, MMP-1, CAT and other targets were closely related to LUAD. The KEGG analysis showed that target genes were enriched in several key cancer-related signaling pathways, including the Fluid shear stress and athero¬sclerosis, Pathways in cancer, AGE-RAGE signaling pathway, p53 signaling pathway, etc. Conclusions The present study investigates the main active compo¬nents, targets and related pathways of Weimaining in the treatment of LUAD, which provides the theoretical basis and ideas for further research.
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OBJECTIVE： To investigate the potential effective components and mechanism of Achyranthes bidentata in the treatment of osteoporosis （OP）. METHODS： The effective components of A. bidentata were retrieved from the TCMSP database， and corresponding targets of them were collected. The targets related to OP were retrieved from DisGeNET database. TBtools 1.0 mapping software was used to draw the Wayne diagram， and screen the intersecting targets of effective components of A. bidentata and disease OP. Cytoscape 3.6.1 software and STRING database were used to construct and analyze the “drug-component- disease-target” network and protein-protein interaction （PPI） network； KEGG pathway enrichment analysis was conducted by using DAVID bioinformatics resource database. RESULTS： A total of 19 effective components were screened from A. bidentata， and there were 32 intersecting targets between effective components and disease OP. In “drug-component-disease-target” network， there were 45 nodes [1 for A. bidentata， 1 for OP， 11 for effective components （8 of the 19 effective components had no corresponding OP target）， 32 for intersecting targets] and 119 edges between nodes； quercetin， kaempferol， wogonin， baicalein and palmatine were important effective components. In PPI network， there were 31 nodes （1 of 32 intersecting targets was not associated with other proteins） and 212 edges， among which IL6， ESR1， MAPK1， IL8 and MAPK14 were the core targets of the network. There were 67 KEGG enrichment pathways， including rheumatoid arthritis， hepatitis B， Toll-like receptor signaling pathway， PI3K/Akt signaling pathway， JAK/STAT signaling pathway， NF-κB signaling pathway and so on. CONCLUSIONS： The main potential effective components of A. bidentata in the treatment of OP are quercetin， kaempferol， wogonin， baicalein and palmatine， the mechanism of which may be associated with cell differentiation and apoptosis， metabolism， inflammation reaction， etc. It has multi-component， multi-target and multi-system chara- cteristics.
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Objective To reveal the cooperation between American military medical research institutes by analyzing the scientific research cooperation networks in order to provide reference for domestic military medical research and its cooperation. Methods A co-occurrence matrix of high frequency research institutes was established by identif-ying the data using literature data analyzing tool TDA and analyzed by visualized tool Ucinet. Results The densely distributed academic cooperation networks in American military medical research institutes were characterized by small world properties and rapid internal knowledge flow with neither absolute knowledge barrier nor knowledge mo-nopolies. The number of co-authorship papers published by military medical research institutes was rather large and tended to increase year by year. The small size research institutes preferred to cooperate between each other. American military medical research institutes did not arbitrarily cooperate with high level research institutes and u-sually cooperated with the same kind of research institutes, including military medical universities, first class uni-versities, and top enterprises. Geo-factor was the most important factor for cooperation in research. Conclusion Frontier basic research, applied basic research, applied military and civilian research should encourage the exten-sive cooperation between military research institutes and excellent civilian research institutes by making full use of the geo-advantages of military medical research institutes. Administrative order and policies should be taken to pro-mote cooperation in military applied research field.
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Objective To reveal the cooperation between American military medical research institutes by analyzing the scientific research cooperation networks in order to provide reference for domestic military medical research and its cooperation. Methods A co-occurrence matrix of high frequency research institutes was established by identif-ying the data using literature data analyzing tool TDA and analyzed by visualized tool Ucinet. Results The densely distributed academic cooperation networks in American military medical research institutes were characterized by small world properties and rapid internal knowledge flow with neither absolute knowledge barrier nor knowledge mo-nopolies. The number of co-authorship papers published by military medical research institutes was rather large and tended to increase year by year. The small size research institutes preferred to cooperate between each other. American military medical research institutes did not arbitrarily cooperate with high level research institutes and u-sually cooperated with the same kind of research institutes, including military medical universities, first class uni-versities, and top enterprises. Geo-factor was the most important factor for cooperation in research. Conclusion Frontier basic research, applied basic research, applied military and civilian research should encourage the exten-sive cooperation between military research institutes and excellent civilian research institutes by making full use of the geo-advantages of military medical research institutes. Administrative order and policies should be taken to pro-mote cooperation in military applied research field.
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Objective To construct novel 3-D composite bionic network and evaluate the histocompatibility . Meth?ods The novel 3-D composite bionic network was prepared from chitosan, hydroxyapatite, gelatin and pectin in certain ra?tio by biomimtic approach, which was co-cultured with MC3T3-E1. The cell compatibility was studied by using inverted phase contrast microscope, routine paraffin section staining, scanning electron microscopy and F-DA staining. The resultant scaffold material was implanted into the dorsal subcutaneous space of SD rats. The histocompatibility, blood vessel capabili?ties and the degradation of the material were observed 2, 4, 8 and 12 weeks after surgery. Results The structure of novel 3-D composite bionic network was three-dimensional and porous. The cells attached on scaffolds attached and grew well with polygonal or fusiform form. It was found that inflammatory reactions were alleviated gradually in the early stage . There was an increasing angiogenesis at late stage. Materials degraded and absorbed more slowly. Conclusion The present study sug?gests that the novel 3-D composite bionic network has good histocompatibility with easy vascularization, and will be a candi?date scaffold for bone tissue engineering.
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Objective To explore the feature of functional connectivity of default mode network (DMN) and salience network (SN) in unmedicated schizophrenia patients during a resting state by functional magnetic resonance imaging (fM-RI). Methods The SPM8 and DPARSFA softwares combined with independent component analysis (ICA) were used to in-vestigate functional connectivity (FC) of the DMN and SN in 27 unmedicated patients with schizophrenia and 27 age-and gender-matched healthy controls. Results Concerning the DMN, patients with schizophrenia showed decreased FC in right inferior frontal gyrus , right precuneus(unadjusted P<0.05)and increased FC in right middle cingulate gyrus, left middle frontal gyrus(unadjusted P<0.05). With regard to the SN, patients showed reduced connectivity in left inferior frontal gyrus, right inferior frontal gyrus, left anterior cingulate, left postcentral gyrus(unadjusted P<0.05)and increased connectivity in left superior temporal gyrus(unadjusted P<0.05). Correlation analyses showed that the increased FC of left superior temporal gyrus significantly correlated with PANSS-positive symptoms(r=0.568,P=0.002)and decreased FC of right precuneus significantly negatively correlated with delusion symptom(r=-0.458,P=0.016). Conclusion This study provides evidence for resting state functional abnormalities of DMN and SN in unmedicated schizophrenia patients. These aberrant function connectivities in some brain regions of the two networks could be a source of abnormal introspectively-oriented mental actives.
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O artigo apresenta o programa Tecendo Redes de Paz desenvolvido pela Área Técnica de Cultura de Paz, Saúde e Cidadania da Secretaria Municipal de Saúde de São Paulo, responsável pela elaboração das políticas públicas articuladas de prevenção, promoção à saúde e de atenção integral às pessoas em situação de violência. O objetivo do programa é diminuir o impacto da violência e dos acidentes sobre os cidadãos da cidade de São Paulo, e contribuir para o processo de construção de uma cultura de paz e da não-violência. Em termos de estratégias, o programa investiu na formação de uma Rede de Cuidados em todas as regiões da cidade, procurando sensibilizar e capacitar os profissionais para lidar com a violência. Fortaleceu o trabalho em rede intersetorial para suscitar a criação das Redes de Paz, e contribuiu para a implantação do Sistema de Informação para a Vigilância de Violências e Acidentes - Sivva. Em termos de resultados, o programa alcançou colocar a violência como um problema de saúde pública de forma mais consolidada na Secretaria da Saúde Municipal de São Paulo, e observa-se que os trabalhadores da saúde estão interessados em participar da construção das Redes de Paz.
The article presents the program Tecendo Redes de Paz (Weaving Peace Networks), developed by the Technical Area of the Culture of Peace, Health and Citizenship of the Municipal Health Department of São Paulo, responsible for the development of the articulated public policies of prevention, health promotion and integral care for people in violence situations. The program aims to reduce the impact of violence and of accidents on the citizens of the city of São Paulo, and to contribute to the process of construction of a culture of peace and non-violence. In terms of strategies, the program invested in the formation of a Care Network in all regions of the city, trying to qualify the professionals to deal with violence. It strengthened the work in inter-sector networks in order to create the Peace Networks, and contributed to the implementation of the Information System for Violence and Accidents Surveillance (Sivva). As for results, the program successfully placed violence as a public health problem in a more consolidated way in the Municipal Health Department of São Paulo, and it has been observed that the health workers are interested in participating in the construction of the Peace Networks.
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Public Policy , Violence , Information Systems , Community Networks , Health Promotion , Comprehensive Health CareABSTRACT
With development of medical imaging,especial the wide application of CT,MRI and so on,traditional education method can not meet the needs of the intern-clinical students.Fairly satisfying teaching effects has been achieved for the effective combination of traditional teaching methods with net-work educational method.
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Thearticlediscussedtheimportanceofmanpowerresourcesmanagementinhospitallibrary underthenetworkenvironment .Itshowedthatliterature ,equipmentandtalentmadeupthelibrary resources ,whichworkedtogether .Builduptheefficiencyofmanpowerresourcesinhospitallibraryandmeasurestoimprovethequalityoftalentwerealsoputforward .