ABSTRACT
@#Periodontal ligament stem cells (PDLSCs) have the potential for multidirectional differentiation and are the preferred seed cells for periodontal tissue regeneration. In recent years, a large number of studies have confirmed that PDLSCs also possess broad immunomodulatory properties. Therefore, in-depth exploration of their specific molecular mechanisms is of great significance for the treatment of periodontitis. The aim of this paper is to summarize the research progress on the regulation of PDLSCs on various immune cells and the effect of the inflammatory environment on the immune characteristics of PDLSCs to provide an important theoretical basis for the allotransplantation of PDLSCs and improve the therapeutic effect of periodontal tissue regeneration. Studies have shown that PDLSCs possess a certain degree of immunosuppressive effect on both innate and acquired immune cells, and inflammatory stimulation may lead to the impairment of the immunoregulatory properties of PDLSCs. However, current studies are mainly limited to in vitro cell tests and lack in-depth studies on the immunomodulatory effects of PDLSCs in vivo. In vivo studies based on cell lineage tracing and conditional gene knockout technology may become the main directions for future research.
ABSTRACT
The relationship between inflammation and cancer has long been the focus of the medical research direction,the infiltration of inflammatory cells is always accompanied by the evolution process of malignant tumor,a lot of inflammatory cells and tumor cells are mutually induced,and lead to a inflammation cascade reaction,finally gradually form an immune network of inflammatory tumor,which not only involves in the occurrence and development of tumor,but also affects the prognosis of patients.In recent years,clinical studies have confirmed that the detection of peripheral blood related inflammatory immune cells can accurately predict the prognosis of hepatocellular carcinoma.Based on the collection of related information at home and abroad,a summary was made to clarify the effects of inflammatory immune cells on the prognosis of hepatocellular carcinoma.
ABSTRACT
Phosphatidylinositol 3 kinase/serine/threonine kinase B (PI3K/Akt) signaling pathway plays a key role in regulating immune response and inflammatory factor release in vitro and in vivo by regulating the activation of downstream signaling molecules, and is closely related to the occurrence and development of sepsis. Innate immune cells play important roles in maintaining the stability of the environment and regulating the immune response during sepsis. This review summarized the PI3K/Akt signaling pathway and its regulation in the sepsis of different types of immune cells in the inflammatory response, apoptosis and other aspects to provide clues and pathways for the prevention and treatment of sepsis.
ABSTRACT
Objective:To investigate the early diagnosis value of neutrophilic CD 64 index(nCD64 ID),neutrophilic CD32 index( nCD32 ID) in ascites and CRP in blood of liver cirrhosis patients combined with spontaneous bacterial peritonitis. Methods:The data of 156 cases with liver cirrhosis was analyzed retrospectively, which CD32 index, CD64 index and CRP were detected respectively and ROC curve analysis were performed. Results:The nCD64 ID,nCD32 ID and CRP in bacterial infection group were all significantly higher than that in no infection group(P<0. 001). The sensitivity and specificity of nCD32 ID,nCD64 ID and CRP were 82. 8%,96. 2%,72. 5% and 81. 0%, 95. 8%, 73. 1% respectively. Conclusion: The sensitivity and specificity of nCD64 ID were higher than nCD32 ID and CRP. The nCD64 ID can be used as an effective index for early diagnosis and differential diagnosis of liver cirrhosis combined with spontaneous bacterial peritonitis.