ABSTRACT
A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS.
Subject(s)
Child , Humans , Infant , Biopsy , Coloring Agents , Cytoplasm , Forearm , Granular Cell Tumor , Nevus , Parturition , S100 Proteins , VimentinABSTRACT
Nevus lipomatosus superficialis is a rare type of benign hamartomatous skin lesion characterized by the presence of mature adipose tissues in the dermis; it usually manifests as a protruding papule or groups of papules or nodules that have smooth or wrinkled surfaces. We report a case of nevus lipomatosus superficialis without external manifestations in a 49-year-old woman.
Subject(s)
Female , Humans , Middle Aged , Dermis , Nevus , SkinABSTRACT
Nevus lipomatosus superficialis is an uncommon form of connective tissue nevus and is manifest principally by the deposition of fatty tissue in the dermis. In this disease two clinical types are distinguished. The classic type consists of asymptomatic linear, soft, flesh-colored to yellowish papules or nodules that often coalesce into plaque. It is usually located in the pelvic girdle and lumbar area. The solitary form usually appears later in life and can occur at any site. Clinically, it may be confused with neurofibroma and acrochordon. The solitary form has been described as a pedunculated lipofibroma. There is no sexual predilection or hereditary trend. The authors experienced two cases of solitary nevus lipomatosus superficialis. The first case was a 57-year-old male who had a solitary, 1 cm-diametered, flesh-colored, polypoid nodule on the buttock for 4 years. The second case was a 32-year-old female who had a 1.5 cm-diametered, flesh-colored and light brown, polypoid nodule on the right flank for 10 years. Diagnosis was confirmed by clinical and histopathologic findings.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Adipose Tissue , Buttocks , Connective Tissue , Dermis , Light , Neurofibroma , NevusABSTRACT
Nevus lipomatosus superficialis presented as soft, yellowish papules or cerebriform plaques occurring usually on the buttock or thigh, less often on the ear or scalp. We herein report a case of nevus lipomatosus superficialis on the leg.
Subject(s)
Buttocks , Ear , Leg , Nevus , Scalp , ThighABSTRACT
A 45-year-old woman had a bean-sized, asymptomatic, soft nodule on the right buttock for 4 years. Histopafhologic evaluation revealed acanthosis and a central core of adipose tissue with thin papillary and reticular dermis containing eccrine glands. Staining with alcian blue showed a slight increase of mucopolysaccharides in the reticular dermis. We made the diagnosis of pedunculated lipofibroma as a solitary form of nevus lipomatosus superficialis.