ABSTRACT
Objective@#To compare the clinical effect of metoprolol combined with valsartan and nifedipine controlled release tablets in the treatment of primary hypertension complicated with coronary heart disease(CHD).@*Methods@#200 primary hypertension patients with CHD were selected, and they were randomly divided into observation group and control group according to the digital table, 100 cases in each group.The observation group was treated with metoprolol combined with valsartan, the control group was treated with nifedipine controlled release tablets.The clinical effect of the two groups was compared.@*Results@#Before treatment, the diastolic and systolic blood pressure of the control group were (106.8±12.3)mmHg and (173.4±22.8)mmHg, respectively, which of the observation group were (104.3±11.4)mmHg, (177.6±24.2)mmHg, respectively, the differences were not statistically significant between the two groups(t=1.265, 0.337, all P>0.05). The diastolic and systolic blood pressure after treatmentin of the observation group were (131.6±17.4)mmHg, (85.3±7.1)mmHg, respectively, and the total effective rate of the observation group was 93.0%(93/100), the improvement rate of angina symptoms of the observation group was 86.0%(86/100), which were significantly better than those of the control group[(131.6±17.4)mmHg, (85.3±7.1) mmHg, 68.0%(68/100), 63.0%(63/100)], the differences were statistically significant (t=5.229, 6.122, χ2=9.148, 7.224, all P<0.05).@*Conclusion@#The combination of metoprolol and valsartan has better effect in the treatment of primary hypertension complicated with CHD compared with nifedipine controlled release tablets.
ABSTRACT
Objective To study the antihypertensive effects and treatment compliance of extended release nifedipine tablets and nifedipine controlled release tablets .Methods 120 cases of patients with hypertension from April 2012 to April 2013,with informed consent of patients and in accordance with the medical ethics standard ,were divided into the group I and group II of 60 cases in each group according to the random number table method , the group I was given extended release nifedipine tablets for treatment while the group II was given nifedipine controlled release tablets for therapy ,antihypertensive effect ,treatment compliance and adverse reaction of two groups were com-pared.Results The total efficiency of group II was 93.3%,which was higher than 80.0%of the group I,there was statistically significant differences between the two groups (χ2 =12.019,P=0.019);The adverse reaction rate of group II was 8.3%,which was significantly lower than 18.3%of the group I,there was statistically significant differ-ences between the two groups (χ2 =11.271,P=0.021);The treatment compliance of group II was 96.7%,which of the group I was 95.0%,there was no significant differences between the two groups (χ2 =5.419,P =0.067). Conclusion Nifedipine controlled release tablets has a better antihypertensive effect ,with less adverse reaction when compared with nifedipine controlled release tablets .