The association of Nodal signaling pathway and the pathogenesis of transposition of TGA / 中华胸心血管外科杂志

Transposition of the great arteries(TGA) is one of the most common and severely congenital heart defects in the neonatal period,even though we have significantly improvement in prenatal diagnosis and postpartum treatment of TGA,patients with severely TGA still have no promising prognosis.Now,the exactly pathogenesis of TGA is still unknown,in the view of embryonic development,TGA is a kind of conotruncal anomalies,which highly associated with unbalanced development of left-right axis.Nodal signaling pathway is one of the most functional pathway in controlling the formation of left-right axis,so fully investigation of Nodal signaling pathway may help us to find deep pathogenesis of TGA.