A Case of Nodular Cystic Fat Necrosis Presenting as Highly Migrating Subcutaneous Nodules / 대한피부과학회지

Nodular cystic fat necrosis is a distinct benign subcutaneous nodule characterized by encapsulated necrosis of subcutaneous fat in which non-viable adipose cells are pathologically surrounded by fibrous tissue. We report a case of nodular cystic fat necrosis in a 47-year-old woman who presented with a 2-month history of had multiple highly- movable, subcutaneous nodules on both shins and posterior thigh. There was an absence of any noteworthy trauma history. Each lesion showed a highly-migratory property, and could easily be moved about 10 cm in any direction. Plain film revealed multiple radiopaque nodules on the right shin. Calcification and lipomembranous changes, in addition to typical features, were also found on histopathologic examination.

Two Cases of Nodular Cystic Fat Necrosis Possibly Related to Previous Trauma

Nodular cystic fat necrosis, first described by Przyjemski and Schuster, is a peculiar form of encapsulated necrosis of subcutaneous fat characterized by totally or near-totally encapsulated necrosis of fatty tissue in which clusters of nonviable adipocytes are surrounded by condensed fibrous tissue. We report two cases of nodular cystic fat necrosis associated with history of trauma about the site of the lesion. Each lesion was a subcutaneous movable nodule on buttock (case 1) and shin (case 2) which has evolved over months. Both cases showed possible relation to multiple intramuscular injection or direct trauma injury. Pathologically, encapsulated nodule showed a characteristic feature of nodular cystic fat necrosis which composed of the ghosts of anucleated adipocytes showing fairly well-preserved outline.

A Case of Nodular Cystic Fat Necrosis / 대한피부과학회지

Nodular cystic fat necrosis(NCFN), first described by Przyjemski and Schuster, is characterized clinically by solitary or multiple asymptomatic mobile subcutaneous nodules on the lower extremities of healthy adolescent boys or middle-aged women, and histologically by encapsulated fat necrosis. We report a case of NCFN with calcification and lipomembranous change in 37-year-old woman.

Two Cases of Nodular-cystic Fat Necrosis

Nodular-cystic fat necrosis is an unusual, distinctive entity characterized by histologically en-capsulated fat necrosis in the subcutis. We report two cases of nodular-cystic fat necrosis. The lesions were subcutaneous nodules. Histopathologically, the nodules showed strong periodic acid-Schiff -positive necrotic adipose tissue with lipomembranous changes and calcification.