Hidradenoma nodular maligno / Malignant Nodular Hidradenoma

Introducción: El hidradenoma nodular maligno es un tumor maligno de glándula sudorípara ecrinas, poco común, considerada una lesión de diferenciación anexial ecrinas, que generalmente surge de nuevo, aunque se han descrito unos pocos casos surgidos sobre un hidradenoma nodular. Es decir, representa la contrapartida maligna del hidradenoma nodular. Objetivo: Dar a conocer la presentación de un caso, dada la inusual aparición de esta entidad, con revisión de los criterios para su diagnóstico. Caso clínico: Se informa el caso de un hombre de 74 años de edad con una neo formación en la región parietal derecha del cuero cabelludo. Conclusiones: Debemos pensar en un hidradenoma nodular maligno ante un tumor solitario, firme o fluctuante, infrecuente en el cuero cabelludo, con curso agresivo, recurrencias y metástasis ganglionares y confirmar su diagnóstico con el estudio inmunohistoquímico(AU)

Introduction: Malignant nodular hidradenoma is a rare malignant eccrine sweat gland tumor considered a lesion of eccrine adnexal differentiation, which usually arises again, although a few arising cases on nodular hidradenoma have been described. In other words, it represents the malignant counterpart of nodular hidradenoma. Objective: To report a case, given the unusual occurrence of this entity, with a review of the criteria for its diagnosis. Case report: We report the case of a 74-year-old man with a neoformation in the right parietal region of the scalp. Conclusions: We should consider a malignant nodular hidradenoma when faced with a solitary, firm or fluctuant tumor, rare in the scalp, with aggressive evolution, recurrences and lymph node metastasis, and confirm its diagnosis with immunohistochemical study(AU)

Malignant nodular hidradenoma-inguinal region clinically masquerading as squamous cell carcinoma: a case report

Malignant Nodular hidradenoma is an extremely rare aggressive tumour originating from eccrine sweat glands with an incidence of <.001%. So far less than 80 cases have been reported in the literature. It’s known for its local recurrence (50%) and metastasis (60%) and hence early diagnosis and radical treatment is mandatory. But differentiating it from its benign counterparts and other skin tumour mimics is challenging, due to its histopathological similarity & lack of diagnostic immunomarkers. Authors report a case of 65-year-old female who presented with a short 4-month history of rapidly growing ulceroproliferative growth in the right inguinal region with bilateral inguinal node enlargement, associated with pain and discharge. Wedge biopsy of left inguinal lymph node showed malignant cutaneous adnexal tumour deposits, which after excision was typed as malignant nodular hidradenoma. It was confirmed with immunohistochemistry. Patient presented with recurrence 8 months after excision.

Axillary Nodular Hidradenoma in a 29-Month-Old Girl / 소아외과

Nodular hidradenoma was diagnosed in a 29-month-old girl on her axilla. Hidradenoma, sometimes designated as acrospiroma, is a benign sweat gland neoplasm, which mostly occurs in adults. Very few cases of hidradenoma have been documented in children in their first decade of life. This case demonstrates that when a child develops a skin nodule, nodular hidradenoma can be a diagnostic option.

A Case of Nodular Hidradenoma of Upper Eyelid Presenting with Ptosis

PURPOSE: To report the presentation and management of an atypical and advanced case of nodular hidradenoma of the eyelid with ptosis. CASE SUMMARY: A 64-year-old woman who presented with a palpable growing nodular mass and ptosis was tested with marginal reflex distance 1 as right eye 1 mm, left eye -1.5 mm and levator function test as 12 mm and 10 mm, respectively during a hospital visit. The patient was tentatively diagnosed with eyelid adnexal tumor with mechanical ptosis and was managed by surgical excision of the lesion. Histology confirmed hidradenoma. CONCLUSIONS: Hidradenomas are benign adnexal tumors originating from the eccrine gland and rarely detectable in the eyelid. However, rudimentary glandular structures can be a possible tumor source. Nodular hidradenoma should be considered in the differential diagnosis of adnexal masses and such lesions may cause significant functional and cosmetic morbidity despite their histologically benign nature.

Uncommon Soft Tissue Tumors with Characteristic Ultrasound Findings: Radiologic - Pathologic Correlation

The role of ultrasound (US) is limited in the pathologic diagnosis of soft tissue tumors. It is possible to predict the pathologic results of some common soft tissue tumors with typical US features. We report the US and pathologic findings of three angiolipomas, one nodular hidradenoma, and one benign myofibroblastic tumor, which are uncommon soft tissue tumors with characteristic US findings.

Clear Cell Hidradenoma in a Young Male Nipple: A Case Report

PURPOSE: Clear cell hidradenoma, now regarded as an eccrine sweat gland tumor on the basis of its enzyme histochemical and electron microscopic features, occurs as a solitary tumor in most instances. METHODS: A 17 year old male presented with asymptomatic nodule, which had developed on nipple with a four years of history and total excision and purse-string suture was then performed. RESULTS: No recurrence was observed 2 months after excision. Histologically, it showed a well circumscribed tumor composed of characteristic clear epithelial cells which are focally arranged in glandular patterns. CONCLUSION: This case is unique in that the tumor developed on the young male nipple, unusual site and this report emphasizes the benefit of local excision to prevent recurrence of these tumor.

A Case of Giant Malignant Clear Cell Hidradenoma / 대한이비인후과학회지

Originating in the eccrine gland and occurring mostly in those above 50 years-old, malignant clear cell hidradenoma is a very rare type of tumor, compared to the common benign hidradenoma. To the author's knowledge, there have been only 4 cases reported worldwide of the malignant transformation, especially in nodular hidradenomas. Clinical manifestation of malignant clear cell hidradenoma includes an appearance of a single tumor generally in either extremities or head, which prevails for a long period and then suddenly enlarges from external stimuli, such as trauma, electrical cauterization or incomplete excision. With its aggressive behavior, it frequently recurs after surgical excision and has high tendency for regional and distant metastasis. We report on our experience on a 75 year-old woman with a 15*7*8 cm malignant clear cell hidradenoma, a malignant tranformation in the long standing nodular hidradenoma, in the right postauricular region and the parotid gland region.

A Case of Malignant Nodular Hidradenoma / 대한피부과학회지

Malignant nodular hidradenoma was first reported by Liu in 1949, and it is an uncommon appendage tumor that presents on head, trunk, or extremities. It has been known as nodular hidradenocarcinoma, malignant clear cell hidradenoma, clear cell hidradenocarcinoma, and accepted as a tumor of the eccrine sweat glands. Histopathologically, tumor is composed of lobulated masses and contains tubular structures with cystic space formation. The cells forming the nest have two populations of clear cells and basophilic polyhedral cells. We report a case of malignant nodular hidradenoma composed of a small proportion of clear cells.

A Case of Nodular Hidradenoma with Apocrine Differentiation / 대한피부과학회지

Nodular hidradenoma is a relatively infrequent benign tumor that shows differentiation from or toward the structure of the eccrine sweat gland. We report a case of nodular hidradenoma with apocrine differentiation in a 74-year old female who had an asymptomatic, 3.5x2.7x1.0cm-sized, smooth-surfaced, round, erythematous to bluish tumor mass with cystic grape-like nature on the right thigh for 3 years. Histological findings showed a well-circumscribed tumor composed of solid portions with fusiform basophilic cells and clear round cells, cystic spaces, tubular lumina, squamoid feature and decapitation secretion.

A Clinical Experience of Malignant Nodular Hidradenoma in Face

Sweat gland carcinoma is the uncommon neoplasm, with few cases reported in the literatures. In a review of literatures, the most commonly used term is malignant nodular hidradenoma; however, similar cases also have been known as a malignant clear cell hidradenoma, malignant clear cell myoepithelioma, clear cell eccrine carcinoma and malignant clear cell acrospiroma. It is difficult to differentiate clinically between sweat gland carcinomas and other skin lesion, such as keloids, sebaceous cyst, dermatofibroma, lymphoma, and squamous cell carcinoma. Thus, a preoperative diagnosis of sweat gland carcinoma is rarely made and histologic examination is the only means of diagnosis. Most sweat gland carcinomas are found on the scalp, face, upper extremities, and axilla. The lesions are typically small, very slow growing, painless nodules. However, it is aggressive, infiltrative, and has highly recurrent rate. Lymph node metastases are frequent and overall survival is poor. So, that must be treated with wide local excision of the lesion and primary regional node dissection is recommended.We have experienced of a case of malignant nodular hidradenoma in cheek area. It was widely excised by total parotidectomy and covered by scapula fasciocutaneous free flap. We report this case with the review of the literature.

A Clinical Experience of Malignant Nodular Hidradenoma in Face

Sweat gland carcinoma is the uncommon neoplasm, with few cases reported in the literatures. In a review of literatures, the most commonly used term is malignant nodular hidradenoma; however, similar cases also have been known as a malignant clear cell hidradenoma, malignant clear cell myoepithelioma, clear cell eccrine carcinoma and malignant clear cell acrospiroma. It is difficult to differentiate clinically between sweat gland carcinomas and other skin lesion, such as keloids, sebaceous cyst, dermatofibroma, lymphoma, and squamous cell carcinoma. Thus, a preoperative diagnosis of sweat gland carcinoma is rarely made and histologic examination is the only means of diagnosis. Most sweat gland carcinomas are found on the scalp, face, upper extremities, and axilla. The lesions are typically small, very slow growing, painless nodules. However, it is aggressive, infiltrative, and has highly recurrent rate. Lymph node metastases are frequent and overall survival is poor. So, that must be treated with wide local excision of the lesion and primary regional node dissection is recommended.We have experienced of a case of malignant nodular hidradenoma in cheek area. It was widely excised by total parotidectomy and covered by scapula fasciocutaneous free flap. We report this case with the review of the literature.