ABSTRACT
@#Although melanoma only accounts for 1% of skin cancers, it is responsible for most skin cancer deaths. Glioblastoma multiforme, a high-grade astrocytoma, is the most aggressive and devastating primary brain tumor. These two diseases remain to be the biggest therapeutic challenge in both specialties of dermatology and neuro-oncology. A 53-year-old Filipino male who presented with a 2-year history of generalized dark brown and black patches on the body developed weakness and numbness of the left extremities. Biopsy and immunohistochemical staining of the skin revealed nodular melanoma with adjacent regressing melanoma. Biopsy of the intracranial mass showed glioblastoma multiforme. One month after the partial excision of the intracranial mass, the patient expired due to brain herniation. Nodular melanoma and glioblastoma multiforme may occur concomitantly in a patient. A review of the literature suggests a shared genetic predisposition. Its existence carries a poor prognosis and requires early detection to start aggressive treatment.
Subject(s)
Melanoma , Glioma , Glioblastoma , AssociationABSTRACT
Resumen El melanoma primariovariedad rabdoide es unapresentación pocofrecuente.Reconocido como un subtipo histopatológico distinto de melanoma maligno generalmente observado en tumores metastásicos o recurrentes.El diagnóstico definitivo requiere el estudio de inmunomarcación y la identificación de células neoplásicas con marcadores melanocíticos. Clínicamente se han reportado mayormente de tipo nodular y amelanótico.
Summary Rhabdoid melanoma has been recognized as a histopathological subtype of malignant melanoma. It generally presents as a recurrent tumor, so its presentation as a primary lesion is infrecuent.Definitive diagnosis requires the study of immunostaining and the identification of neoplastic cells with melanocytic markers. Clinically, mostly nodular and amelanotic types have been reported.
ABSTRACT
Nodular type malignant melanoma is uncommon in fingers. In previous publications, treatment, diagnosis and case reports of subungal melanoma is often, however fingertip lesion was not focused. A 64-year-old woman who had a non-healing red and dark colored nodular mass with ulceration over the finger tip in the right thumb visited our clinics. Biopsy results was malignant melanoma then we performed amputation surgery of distal phalanx. Lymph node biopsy and resection margin was negative for melanoma. Chemotherapy was administered immediately. After 5 months, pulmonary nodular lesion was found and diagnosed as metastatic malignant melanoma by the wedge resection surgery. The patient is treated for additional chemotherapy consistently and disease free for 2 years. Nodular type melanoma of the finger is uncommon and it could be presented as ulceration and amelanotic nodular mass. Therefore we recommend biopsy to diagnose correctly if there are chronic non healing lesions on the fingers.
Subject(s)
Female , Humans , Middle Aged , Amputation, Surgical , Biopsy , Diagnosis , Drug Therapy , Fingers , Lymph Nodes , Melanoma , Thumb , UlcerABSTRACT
Antecedentes: El melanoma maligno es una neoplasia derivada de los melanocitos que suelen localizarse en la unión dermoepidérmica. A pesar de que su incidencia es baja, menor de 10%, 75% de las muertes por cáncer cutáneo se debe a esta neoplasia. Existen cuatro variantes: de extensión superficial, léntigo melanoma maligno, acral lentiginoso y nodular. En la población caucásica predomina el melanoma de extensión superficial; en series mexicanas se ha encontrado que prevalece el nodular. El objetivo de este estudio fue describir los casos de melanoma maligno del Hospital General Dr. Manuel Gea González para establecer la frecuencia de presentación y el subtipo clínico. Métodos: Se realizó estudio retrospectivo, descriptivo y transversal, de marzo de 1981 a diciembre del 2006, de los pacientes con melanoma; se registró sexo, edad, residencia, ocupación, evolución de la lesión, topografía y manifestaciones clínicas. Histológicamente se valoró el índice de Breslow y el nivel de Clark. Resultados: Se incluyeron 165 pacientes, de los cuales 112 fueron del sexo femenino y 53 del masculino. La localización más frecuente fue la extremidad inferior. El melanoma acral lentiginoso fue el que mostró mayor prevalencia. Conclusiones: En esta serie los subtipos con mayor prevalencia fueron el melanoma acral lentiginoso y el léntigo maligno melanoma, a diferencia de otras series donde se informa el nodular y el de extensión superficial. La proporción mujer:hombre fue de 2.1:1, mayor a la indicada en otras series.
BACKGROUND: Melanoma is a type of tumor that arises from melanocytes generally located in the dermoepidermal junction. Although melanoma is found in less than 10% of cases, mortality is high representing 75% of deaths attributed to cutaneous cancer. There are four major subtypes: Superficial spreading melanoma, lentigo malignant melanoma, acral lentiginous melanoma and nodular melanoma. Superficial spreading melanoma is the most common type among Caucasians. In a Mexican case series, the nodular type is the most common type reported. The aim of this study was to determine the most common type seen at our medical facility. METHODS: We analyzed patient's medical records from March 1981 to December 2006. Demographic data included sex, age, place of residence, occupation, tumor progression, location and clinical description. Histologically we evaluated tumor thickness using the Breslow scale; invasion was measured using the Clark scale. This is a descriptive, cross-sectional and retrospective study. RESULTS: 165 patients were studied, 112 were females and 53 males. The most common location was the lower limb. Acral lentiginous melanoma was the most common subtype. CONCLUSIONS: Our findings differ from the other series where they report nodular and superficial spreading melanoma as the most common types. The most common subtypes in our study were acral lentiginous melanoma and lentigo malignant melanoma among females, with a ratio of female-male of 2.1:1.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged, 80 and over , Melanoma/pathology , Skin Neoplasms/pathology , Cross-Sectional Studies , Hospitals , Melanoma/epidemiology , Skin Neoplasms/epidemiology , Retrospective StudiesABSTRACT
The pedunculated melanoma is considered a more aggressive variant of nodular melanoma. The characteristics of the lesion is connected to the underlying skin by a pedicle or the stalk. 47-years old Korean man presented with a pedunculated mass on the abdomen that had been increasing in size for the last 2 months. The lesion appeared 2 months previously as a flat mark. Histopathologic findings showed that the lesion was consistent with a nodular melanoma.
Subject(s)
Humans , Middle Aged , Abdomen , Melanoma , SkinABSTRACT
The diagnosis of nodular melanomas can be sometimes difficult, in case they lack the conventional clinical features of melanoma. Herein, we report a case of malignant melanoma mimicking seborrheic keratosis. The clinical diagnosis was seborrheic keratosis. The histopathologic examination revealed nodular melanoma with features of reticulated form of epidermal hyperplasia, pseudohorn cysts, and irregular hyperkeratosis and acanthosis. The tumor was excised with 2.5 cm margins and no remnant of tumor cells was found in the microscopic examination.