Bibliometric and bioinformatics analysis of genetic literature on susceptibility to noise induced hearing loss / 中华劳动卫生职业病杂志

Objective: To summarize and analyse of literature on the susceptibility genes of noise induced hearing loss (NIHL) , and the key genes were screened and obtained by bioinformatics method, so as to provide reference for the prevention research of NIHL. Methods: In September 2021, Based on CNKI, NCBI Pubmed database and Web of Science database, this paper conducted bibliometric analysis and bioinformatics analysis on the genetic literature related to the susceptibility to noise-induced hearing loss from 1999 to 2020. Endnote X9 software and the WPS office software were used for bibliometric analysis, and online software STRING and Cytoscape software were used for bioinformatics analysis. Results: A total of 131 literatures were included in the study, involving 40 genes in total. Bibliometric analysis shows that 131 papers which included 36 Chinese articles and 95 English articles were published in 63 biomedical journals; the highest number of published articles was 19 in 2020. Bioinformatics analysis suggests that GAPDH、SOD2、SOD1、CAT、CASP3、IL6 and other genes play a key role in the interaction network. The involved pathways mainly include MAP2K and MAPK activations, PTEN regulation, P53-depardent G1 DNA damage response, signaoling by BRAF and RAF fusions and soon. Conclusion: The study of noise induced hearing loss involves multi gene biological information, and bioinformatics analysis is helpful to predict the occurrence and development of noise induced hearing loss.

Task Analysis On Maintenance Worker (Rail Grinder) Of Light Rail Transit (LRT)

@#Rail maintenance routines are necessary to enable the all rail operations to achieve its aim in maintaining a safe and efficient operation. The maintenance tasks expose the workers to vibration and noise, as they handle specialized machineries and heavy self-propelled vehicles. Exposure of noise above the permissible exposure limit and over the daily allowable duration may cause noise-induce hearing loss (NIHL). Investigation on the type of task that has high noise level exposure on the maintenance workers was conducted to justify the needs to further detailed of this study. This paper will describe the task analysis on maintenance workers and to identify possible tasks with exposure to high level of noise. It scopes down to grinding crew of the maintenance department of light rail transit. Methods used were real-time sound measurement using a sound level meter, observation and interviews. Then, data were analysed to understand the situation of exposure of noise during rail maintenance. An ergonomic risk assessment was also conducted by adoption of the latest guideline on Ergonomic Risk Assessment (ERA) at Workplace Guidelines recommended by Department of Occupational Safety and Health (DOSH), Malaysia. A hierarchical task analysis (HTA) was generated on the task of the maintenance worker, focusing on rail grinding crew. The newly generated HTA had allowed better understanding about the nature of work and the task conducted by a rail grinder during the work shifts. Tasks involving high noise level was identified. Data recorded shows that the noise level for the blowing activity was relatively high and exceeded the permissible exposure limit of 90dBA. The exposure level was currently controlled by practicing the usage of hearing protection equipment (HPE) and by controlling exposure time in accordance to recommendations of the Factory and Machinery Act (FMA). Thus, it had confirmed that maintenance workers were exposed to high noise levels when performing their daily task. Further studies are needed to investigate the relationship between the duration of exposure and noise-induce hearing loss (NIHL) with consideration of the lifestyles of the maintenance workers.

The Hearing Level among the Workers of Cement Industry

Objective: In this study our main goal is to evaluate thehearing level among the workers of cement industry.Methodology: This Cross-sectional observational study wasconducted at Department of Physiology, Chittagong MedicalCollege, Chittagong and Heidelbargh Cement Bangladesh Ltd.East Halishar, Chittagong, One year (January 2011 toDecember 2011). Where total number of 800 (Eight hundred)subjects were included. During the study, all subjects wereselected purposively on the basis of noise exposure studyprocedure. After selection and proper counseling, the aim,objective and procedure of the study was explained in detailsto all subjects, in the cement industry.Results: During the study highest frequency of hearing losswas found in 30-40 years age group. Most of the patientsworked in production area for 5-10 years. most of the patientsexposed to 70-80dB, 41.4%.51.6% patients exposed >8 hoursdaily and 65.5% patients exposed 42-48 hours weekly.Conclusion: From our study we can conclude that the studyclearly demonstrated that noise is a serious health hazard inthe cement industry. Hearing threshold for the subjectsexposed to noise increase with the progress of age andduration of employment. Further study is needed for betteroutcome.

Exposição ocupacional ao ruído em odontólogos do Paraná: percepções e efeitos auditivos / Occupational exposition to noise in dentists of State Paraná: perception and effects on hearing

Introdução: Níveis de pressão sonora intensos podem ser encontrados no ambiente de trabalho do odontólogo devido aos equipamentos utilizados. Esses níveis podem representar um risco à sua saúde. Objetivo: examinar os prováveis efeitos da exposição ocupacional ao ruído na audição de odontólogos, a percepção e o conhecimento dos mesmos acerca dos malefícios da exposição ao ruído e das possibilidades de prevenção. Método: trata-se de um estudo transversal (ou seccional), que avaliou a audição de 219 odontólogos (56,44% mulheres e 43,55% homens); estes também responderam a um questionário para coletar dados relativos à exposição ocupacional ao ruído. Resultado: prevalência de alterações auditivas de 32,51% nos 163 odontólogos incluídos na pesquisa; a ocorrência de alterações auditivas aumentou com a idade e os anos de serviço; com os anos de serviço, aumenta a jornada de trabalho, infuenciando na audição; o ruído no trabalho foi percebido como médio (49,07%); 96,9% conhecem os efeitos do ruído e 3,06% usam protetores auriculares. Concluiu-se que os odontólogos deste estudo apresentam alterações auditivas sugestivas de terem sido induzidas por ruído (razão de prevalência = 1,79 95% IC 0,09-4,44), quando a jornada de trabalho for igual ou superior a oito horas.

Introduction: intense sound pressure levels are found in the work environment of dentists, because of the equipment used. Such levels can represent a health risk. Aim: to examine the effects of occupational noise exposure on dentists' hearing, the beliefs and knowledge they have on noise exposure effects and preventive measures. Method: in this transversal (or cross-sectional) study 163 dentists (56.44 % female and 43.55% males) underwent hearing testing and an interview. Result: the prevalence of hearing loss among participants was of 32.51%; as age and duration of exposure (in years) increased there was an increase in hearing loss; as duration of exposure (in years) increased, the length of their work shift also increased; noise in the workplace was perceived as moderate by 49.07 % of the participants; 96.9% of the participants knew the effects of noise and 3.06% use hearing protector devices. We concluded that dentists in this study have hearing loss suggested by noise-induced (prevalence ratio = 1.79 95% CI 0.09-4.44). The highest prevalence of hearing loss was associated to work shift equal or longer than 8 hours.

Perda auditiva induzida pelo ruído em trabalhadores industriais da Regiäo Metropolitana de Salvador, Bahia / The noise-induced hearing loss in industrial workers of Metropolitan Region, Salvador, Bahia, Brazil

O presente trabalho constitui-se em um estudo de prevalência, realizado a partir de dados audiométricos referentes a 7.925 trabalhadores de 44 empresas industriais de nove diferentes ramos de atividade. A prevalência de perda auditiva foi de 45,9% na população estudada. Em relação à perda auditiva do tipo induzida pelo ruído (PAIR), somando as perdas bilaterais e unilaterais, observou-se uma prevalência de 35,7%. Para cada ramo, as prevalências foram as seguintes: 58,7% no editorial/gráfico, 51,7% no mecânico, 45,9% no de bebidas, 42,3% no químico/petroquímico, 35,8% no metalúrgico, 33,5% no siderúrgico, 29,3% no de transportes, 28,0% no de alimentos e 23,4% no têxtil. Chamam atenção as altas prevalências de PAIR unilateral - 18% dos trabalhadores avaliados. O presente estudo permitiu delinear um quadro extremamente alarmante, dada a magnitude da prevalência de perda auditiva do tipo induzida pelo ruído, apontando a importância da implementação, por parte das empresas, de Programas de Conservação Auditiva.

An audiometric evaluation was conducted in 7,925 workers of fourty-four industrial companies in nine different fields of activity. The hearing loss prevalence was 45.9%. The noise-induced hearing loss (NIHL) prevalence was 35.7% considering bilateral and unilateral losses. For each field of activity, the prevalence estimates were: 58.7% in the graphic, 51.7% in the mechanic, 45.9% in the beverage industry, 42.3% in the chemical/ petrochemical, 35.8% in the metallurgy, 33.5% in the metallurgy of iron and steel, 29.3% in the transport companies, 28.0% in the alimentation industry and 23.4% in the textile industry. Unilateral NIHL was surprisingly high - 18% of the examined workers. These results reveal a serious situation and the authors recommend the implementation of Hearing Conservation Programs in industrial companies.

Mitochondrial DNA and GJB2 Genovariation in Noise-Induced Hearing Loss in the Army / 听力学及言语疾病杂志

Objective To explore the relationship between mitochondrial DNA gene,GJB2 gene mutations and the susceptibility to noise-induced hearing loss in the army,and to provide scientific evidence for gene screening of susceptible individuals and relevant molecular epidemiology.Methods 182 blood samples were collected from 349 soldiers,consisting of susceptible and tolerance groups exposed to military noise in Beijing.Genomic DNA was isolated,and the targeted fragments of mitochondrial DNA and coding region of GJB2 gene were amplified by polymerase chain reaction(PCR).The PCR products were analyzed by direct sequencing.Results The results revealed that there were 98 mtDNA variants(41 reside in 12SrRNA) and 12 GJB2 gene variants;among them,mtDNA T1095C and G7642A coexisted in 4 susceptible individuals,but these mutations were not found in the tolerance group.In addition,3 tolerant individuals carried 961delT+insC while no one was found in the susceptible group.Conclusion The 12SrRNA is an area evidenced by high variant and mutation rate.The coexistence of mtDNA T1095C and G7642A in the susceptible group exposed to the similar noise suggests that these mutations are pathogenic mutations associated with NIHL.Three tolerant individuals with the history of long-term noise exposure carry 961delT+insC,suggesting that 961delT+insC might be a conditional pathogenic mutation,but not correlate with NIHL.

Development of Quick Screener Based on Embedded System for Noise-induced Hearing Loss / 医疗卫生装备

Objective To develop a portable and automatic quick screener for noise-induced hearing loss(NIHL),which is suitable for airman and ground crew.Methods Through using audio decoder chip VS1003 to achieve quick screener for noise-induced hearing loss and pre-exposing for special background noise.LPC2148 of ARM7-TDMI configuration was adopted as main controlling chip,and its software design was completed by multitask scheduler based on UCOS-Ⅱ,while the FAT system controlled the read-write to the files in SD card.The signal emergence,change in hearing class,frequency selection as well as records of subject reaction were automatically achieved.Results The system can produce stable signal of exact frequency according to GBZ49-2002 Diagnostic Criteria of Occupational Noise-induced Hearing Loss to output stability of the frequency and intensity of the audio signal,and the specific context of the noise pre-exposure function with screening of hearing impairment was achieved automatically.Conclusion Based on the great power of embedded system and VS1003,the portable and automatic quick screener for noise-induced hearing loss(NIHL) can be developed to carry out many functions,which has several features,such as simple structure,high integration,good stability and use of flexible etc.