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Objective To establish the evaluation methods of individual technology maturity based on SCI-covered papers and patent data using Gartner's Hype Cycle.Methods The SCI-covered papers and patent data were ana-lyzed by nonlinear regression analysis in combination with traditional X-radiography and photo-acoustic tomo-graphy, and represented as the bell-shaped curve and S-shaped curve for judging the technology maturity.Results The individual technology maturity was consistent with the qualitative review of experts.Conclusion The individual technology described in SCI-covered papers and patent data can be used in primary evaluation of its maturity.
ABSTRACT
Objective To select optimum water extraction process of SuXingErChen Syrup by orthogonal test and multivariate nonlinear regression analysis.Methods Naringin was extracted by water, Used the naringin content and extraction rate of extractum as indexes.Based on the orthogonal test and multivariate nonlinear regression analysis to make sure the best way for extracting naringin from SuXingErChen Syrup.Results The optimal conditions of water extraction process was that the herbs were added seven times the amount of water without infiltration,extracted two times with 80 min each time,which was selected by multivariate nonlinear regression analysis.Conclusion The process of water extraction for the preferred Su XingErChen Syrup is exact, high effective and suitable for production needs.
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The creation of the National Health Insurance program has greatly contributed to giving Japan the world’s highest level of life expectancy. However, the cost of medical care in Japan has increased as a result of an aging society. In response to this reality, the Japanese government initiated a campaign to promote the use of generic drugs (GEs). In order to clarify some of the trends that contribute to different clinical medicine department usages of GEs, we carried out a survey of 400 pharmacies. The survey data was analyzed using linear regression analysis. Analysis of linear equations derived “utilization” that indicated ease of use of GEs, and a “saturation acceptable value (maximum allowed)” that indicated usage of GEs. The breakdown for different clinical medicine department usages of GEs was determined as the following: psychosomatic medicine or psychiatry was 11±0.13%, internal medicine was 29±0.18%, orthopedics was 18±0.14%, ophthalmology or otolaryngology was 15±0.14%, other departments was 17±0.15%. Furthermore, the highest utilization derived by linear regression analysis was orthopedics. The highest acceptable saturation value was for psychosomatic medicine or psychiatry, while the lowest acceptable saturation value was orthopedics. The results of the study confirm the importance of establishing evaluation methods for GE usage, and that linear regression analysis is a powerful tool for revealing trends in GE usage among different departments. Additionally, the study suggests that determining GE spread measures is valuable, since they can serve as an aid to future pharmaceutical administration consideration.
ABSTRACT
Objective To observe the changes of chief chemical components(hypaconitine,ephedrine,pseudoephedrine,peoniflorin,glycyrrhetic acid) in the combinations of different-dose herbs of Wutou Decoction(WD). Methods Uniform design method was adopted to design the experiments,and HPLC was applied to determine the contents of chief chemical components of hypaconitine,ephedrine,pseudoephedrine,peoniflorin,glycyrrhetic acid. DPS V7.55 was used to carry out the nonlinear regression analysis of experimental data such as decocting rates of the chief chemical components. The mathematical model was established to analyze the experimental results. Finally,with the decocting rates of the chief chemical components as the optimizing indexes,the combination of optimal-dose herbs of WD was seeked. Results There existed an interaction between each herb of WD,and each herbs as well as the interaction between the herbs had a certain effects on the decocting rate of the chemical components. In particular,the interaction of prepared Radix Aconiti and prepared Radix Glycyrrhizae had obvious effects on the decocting rates of hypaconitine and glycyrrhetic acid. On the basis of the different optimization index,different combinations of optimal-dose herbs of WD can be obtained. Conclusion Through the method of nonlinear regression analysis,rich connotation of compatibility in Chinese herbal formula can be obtained.The optimization of optimal-dose herbs combination of the formula should be based on the pharmacological actions.